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https://read.qxmd.com/read/29530740/ductus-arteriosus-and-fetal-echocardiography-implications-for-practice
#1
REVIEW
Silvia G V Alvarez, Angela McBrien
The ductus arteriosus (DA) is a crucial part of the fetal circulation, both in the normal fetus and in critical congenital heart disease (CHD). It allows shunting between the pulmonary and systemic circulations. In physiological prenatal conditions, the DA lets the majority of right ventricular output bypass the fluid-filled, high-resistance lungs. The DA can cause hemodynamic compromise in the fetus and neonate when constricted or absent (in isolation or in patients with CHD) and may lead to pre- or postnatal sequelae within other systems when forming part of a vascular ring...
August 2018: Seminars in Fetal & Neonatal Medicine
https://read.qxmd.com/read/30384985/an-update-on-the-diagnosis-and-management-of-bronchopulmonary-dysplasia-bpd-associated-pulmonary-hypertension
#2
REVIEW
Sara K Berkelhamer, Karen K Mestan, Robin Steinhorn
The past decade of neonatal care has been highlighted by increased survival rates in smaller and more premature infants. Despite reduction in mortality associated with extreme prematurity, long term pulmonary morbidities remain a concern, with growing recognition of the clinical burden attributable to infants with bronchopulmonary dysplasia (BPD)-associated pulmonary hypertension (PH). Recent publications shed light on the critical contributions of maternal placental pathology and compromised intrauterine growth to fetal pulmonary vascular development...
November 2018: Seminars in Perinatology
https://read.qxmd.com/read/30401478/an-update-on-pulmonary-and-neurodevelopmental-outcomes-of-bronchopulmonary-dysplasia
#3
REVIEW
Jeanie L Y Cheong, Lex W Doyle
Bronchopulmonary dysplasia (BPD) is a common complication of extreme prematurity, and its rate is not improving, despite advances in perinatal intensive care. Children with BPD diagnosed in the neonatal period have higher risks for hospitalizations for respiratory problems over the first few years of life, and they have more asthma in later childhood. Neonates diagnosed with BPD have substantial airway obstruction on lung function testing in later childhood and early adulthood, and many are destined to develop adult chronic obstructive pulmonary disease...
November 2018: Seminars in Perinatology
https://read.qxmd.com/read/30487070/an-update-on-the-post-nicu-discharge-management-of-bronchopulmonary-dysplasia
#4
REVIEW
Anita Bhandari, Howard Panitch
Bronchopulmonary dysplasia (BPD) is a chronic lung disease which develops as a result of neonatal/perinatal lung injury. It is the commonest cause of chronic lung disease in infancy and the most frequent morbidity associated with prematurity. The incidence of BPD has continued to rise despite many advances in neonatal care and this increase has been attributed to the increased survival of younger and more premature babies. There have been many advances in the care of patients with early and evolving BPD, yet there is a paucity of data regarding outpatient management of patients with established BPD...
November 2018: Seminars in Perinatology
https://read.qxmd.com/read/30545978/paediatric-pulmonary-arterial-hypertension-updates-on-definition-classification-diagnostics-and-management
#5
Erika B Rosenzweig, Steven H Abman, Ian Adatia, Maurice Beghetti, Damien Bonnet, Sheila Haworth, D Dunbar Ivy, Rolf M F Berger
Paediatric pulmonary arterial hypertension (PAH) shares common features of adult disease, but is associated with several additional disorders and challenges that require unique approaches. This article discusses recent advances, ongoing challenges and distinct approaches for the care of children with PAH, as presented by the Paediatric Task Force of the 6th World Symposium on Pulmonary Hypertension. We provide updates of the current definition, epidemiology, classification, diagnostics and treatment of paediatric PAH, and identify critical knowledge gaps...
January 2019: European Respiratory Journal: Official Journal of the European Society for Clinical Respiratory Physiology
https://read.qxmd.com/read/30579586/furosemide-exposure-and-prevention-of-bronchopulmonary-dysplasia-in-premature-infants
#6
Rachel G Greenberg, Sreepriya Gayam, Destiny Savage, Andrew Tong, Daniel Gorham, Ari Sholomon, Reese H Clark, Daniel K Benjamin, Matthew Laughon, P Brian Smith
OBJECTIVE: To evaluate the association between furosemide exposure and risk of bronchopulmonary dysplasia (BPD). STUDY DESIGN: This retrospective cohort study included infants (2004-2015) born at 23-29 weeks gestational age and 501-1249 g birth weight. We compared the demographic and clinical characteristics of infants exposed and not exposed to furosemide between postnatal day 7 and 36 weeks postmenstrual age. We examined the association between furosemide exposure and 2 outcomes: BPD and BPD or death...
December 20, 2018: Journal of Pediatrics
https://read.qxmd.com/read/30546043/late-onset-neonatal-acute-kidney-injury-results-from-the-awaken-study
#7
Jennifer R Charlton, Louis Boohaker, David Askenazi, Patrick D Brophy, Mamta Fuloria, Jason Gien, Russell Griffin, Sangeeta Hingorani, Susan Ingraham, Ayesa Mian, Robin K Ohls, Shantanu Rastogi, Christopher J Rhee, Mary Revenis, Subrata Sarkar, Michelle Starr, Alison L Kent
BACKGROUND: Most studies of neonatal acute kidney injury (AKI) have focused on the first week following birth. Here, we determined the outcomes and risk factors for late AKI (>7d). METHODS: The international AWAKEN study examined AKI in neonates admitted to an intensive care unit. Late AKI was defined as occurring >7 days after birth according to the KDIGO criteria. Models were constructed to assess the association between late AKI and death or length of stay...
December 13, 2018: Pediatric Research
https://read.qxmd.com/read/30553135/intentional-early-delivery-versus-expectant-management-for-preterm-premature-rupture-of-membranes-at-28-32-weeks-gestation-a-multicentre-randomized-controlled-trial-micado-study
#8
Jean-Charles Pasquier, Olivier Claris, Muriel Rabilloud, René Ecochard, Jean-Charles Picaud, Stéphanie Moret, Danielle Buch, Georges Mellier
OBJECTIVES: Preterm premature rupture of fetal membranes (PPROM) exposes the fetus to preterm birth, and optimal timing for delivery is controversial. The aim of this study was to compare intentional early delivery ("active management") with expectant management in very preterm birth (28-32 weeks). STUDY DESIGN: We conducted a prospective randomized controlled trial with intent-to-treat analysis, at 19 tertiary-care hospitals in France and 1 in Geneva, Switzerland...
February 2019: European Journal of Obstetrics, Gynecology, and Reproductive Biology
https://read.qxmd.com/read/30345236/nutritional-support-strategies-for-the-preterm-infant-in-the-neonatal-intensive-care-unit
#9
REVIEW
William W Hay
The goal of nutrition of the preterm infant is to "provide nutrients to approximate the rate of growth and composition of weight gain for a normal fetus of the same postmenstrual age and to maintain normal concentrations of blood and tissue nutrients" (American Academy of Pediatrics 2014). Failure to provide the necessary amounts of all of the essential nutrients to preterm infants has produced not only growth failure, but also increased morbidity and less than optimal neurodevelopment. This continues to be true despite many efforts to increase nutrition of the preterm infants...
October 2018: Pediatric Gastroenterology, Hepatology & Nutrition
https://read.qxmd.com/read/30072808/introduction-to-neonatologist-performed-echocardiography
#10
REVIEW
Alan M Groves, Yogen Singh, Eugene Dempsey, Zoltan Molnar, Topun Austin, Afif El-Khuffash, Willem P de Boode
Cardiac ultrasound techniques are increasingly used in the neonatal intensive care unit to guide cardiorespiratory care of the sick newborn. This is the first in a series of eight review articles discussing the current status of "neonatologist-performed echocardiography" (NPE). The aim of this introductory review is to discuss four key elements of NPE. Indications for scanning are summarized to give the neonatologist with echocardiography skills a clear scope of practice. The fundamental physics of ultrasound are explained to allow for image optimization and avoid erroneous conclusions from artifacts...
July 2018: Pediatric Research
https://read.qxmd.com/read/30314974/is-preterm-nutrition-a-trade-off-between-head-and-heart
#11
EDITORIAL
Gopi Menon, Angela L Davidson, Amanda Jane Drake, Nicholas D Embleton
No abstract text is available yet for this article.
October 12, 2018: Archives of Disease in Childhood. Fetal and Neonatal Edition
https://read.qxmd.com/read/30193751/persistent-hypoglycemia-in-children-targeted-gene-panel-improves-the-diagnosis-of-hypoglycemia-due-to-inborn-errors-of-metabolism
#12
Emanuela Ponzi, Arianna Maiorana, Francesca Romana Lepri, Mafalda Mucciolo, Michela Semeraro, Roberta Taurisano, Giorgia Olivieri, Antonio Novelli, Carlo Dionisi-Vici
OBJECTIVES: To evaluate the role of next generation sequencing in genetic diagnosis of pediatric patients with persistent hypoglycemia. STUDY DESIGN: Sixty-four patients investigated through an extensive workup were divided in 3 diagnostic classes based on the likelihood of a genetic diagnosis: (1) single candidate gene (9/64); (2) multiple candidate genes (43/64); and (3) no candidate gene (12/64). Subsequently, patients were tested through a custom gene panel of 65 targeted genes, which included 5 disease categories: (1) hyperinsulinemic hypoglycemia, (2) fatty acid-oxidation defects and ketogenesis defects, (3) ketolysis defects, (4) glycogen storage diseases and other disorders of carbohydrate metabolism, and (5) mitochondrial disorders...
November 2018: Journal of Pediatrics
https://read.qxmd.com/read/29984201/acute-respiratory-distress-syndrome-an-update-and-review
#13
Gautam Rawal, Sankalp Yadav, Raj Kumar
Acute respiratory distress syndrome (ARDS) is a life threatening condition characterized by severe hypoxemia due to pulmonary gas exchange failure and was first recognized in 1960s.Since its first description, it has undergone intensive research in the past few decades to understand its pathogenesis and therapies. Despite this, the recommended therapies to decrease mortality in ARDS remain limited and include low-tidal volume mechanical ventilation, prone ventilation and recently, the ECMO rescue therapy in extreme cases...
June 2018: Journal of Translational Internal Medicine
https://read.qxmd.com/read/29955859/a-guide-to-utilization-of-the-microbiology-laboratory-for-diagnosis-of-infectious-diseases-2018-update-by-the-infectious-diseases-society-of-america-and-the-american-society-for-microbiology
#14
J Michael Miller, Matthew J Binnicker, Sheldon Campbell, Karen C Carroll, Kimberle C Chapin, Peter H Gilligan, Mark D Gonzalez, Robert C Jerris, Sue C Kehl, Robin Patel, Bobbi S Pritt, Sandra S Richter, Barbara Robinson-Dunn, Joseph D Schwartzman, James W Snyder, Sam Telford, Elitza S Theel, Richard B Thomson, Melvin P Weinstein, Joseph D Yao
The critical nature of the microbiology laboratory in infectious disease diagnosis calls for a close, positive working relationship between the physician/advanced practice provider and the microbiologists who provide enormous value to the healthcare team. This document, developed by experts in laboratory and adult and pediatric clinical medicine, provides information on which tests are valuable and in which contexts, and on tests that add little or no value for diagnostic decisions. This document presents a system-based approach rather than specimen-based approach, and includes bloodstream and cardiovascular system infections, central nervous system infections, ocular infections, soft tissue infections of the head and neck, upper and lower respiratory infections, infections of the gastrointestinal tract, intra-abdominal infections, bone and joint infections, urinary tract infections, genital infections, and other skin and soft tissue infections; or into etiologic agent groups, including arthropod-borne infections, viral syndromes, and blood and tissue parasite infections...
August 31, 2018: Clinical Infectious Diseases: An Official Publication of the Infectious Diseases Society of America
https://read.qxmd.com/read/29808264/neonatal-hypertension-cases-causes-and-clinical-approach
#15
Michelle C Starr, Joseph T Flynn
Neonatal hypertension is increasingly recognized as dramatic improvements in neonatal intensive care, advancements in our understanding of neonatal physiology, and implementation of new therapies have led to improved survival of premature infants. A variety of factors appear to be important in determining blood pressure in neonates, including gestational age, birth weight, and postmenstrual age. Normative data on neonatal blood pressure values remain limited. The cause of hypertension in an affected neonate is often identified with careful diagnostic evaluation, with the most common causes being umbilical catheter-associated thrombosis, renal parenchymal disease, and chronic lung disease...
May 28, 2018: Pediatric Nephrology: Journal of the International Pediatric Nephrology Association
https://read.qxmd.com/read/30006471/the-secret-sauce-secrets-of-high-performing-neonatal-intensive-care-units
#16
EDITORIAL
Lamia Soghier, Billie Lou Short
No abstract text is available yet for this article.
January 2019: Archives of Disease in Childhood. Fetal and Neonatal Edition
https://read.qxmd.com/read/29768264/opportunities-and-challenges-in-global-perinatal-research
#17
Jessica Duby, Renee Sharma, Zulfiqar A Bhutta
BACKGROUND: The global plight of stillbirths and neonatal mortality is concentrated in low- and middle-income countries. The ambitious targets introduced by the World Health Organization in the Every Newborn Action Plan demand a commitment to research that promotes equitable perinatal outcomes. OBJECTIVES: The aim of this review was to understand the opportunities for global perinatal research and the accompanying challenges. METHODS: We conducted a literature search to identify research prioritization exercises from 2014 to 2018 pertaining to global perinatal health...
2018: Neonatology
https://read.qxmd.com/read/29847833/in-preterm-infants-length-growth-below-expected-growth-during-hospital-stay-predicts-poor-neurodevelopment-at-2-years
#18
Laure Simon, Camille Théveniaut, Cyril Flamant, Anne Frondas-Chauty, Dominique Darmaun, Jean-Christophe Rozé
BACKGROUND: In preterm infants, neonatal weight growth is associated with neurodevelopmental outcome but is a poor indicator of growth quality. OBJECTIVE: The aim of this work was to measure the relationship between neonatal length growth and the 2-year neurological outcome in preterm infants. METHODS: A total of 2,403 infants enrolled in the LIFT cohort with gestational age less than 34 weeks were studied. Neonatal observed length growth (OLG) was calculated as the change in length Z-score between birth and discharge...
2018: Neonatology
https://read.qxmd.com/read/29895007/the-postnatal-glucose-concentration-nadir-is-not-abnormal-and-does-not-need-to-be-treated
#19
LETTER
William W Hay, David H Adamkin, Jane E Harding, Jane Hawdon
No abstract text is available yet for this article.
2018: Neonatology
https://read.qxmd.com/read/29898454/neonates-at-risk-of-early-onset-sepsis-which-is-the-best-approach
#20
Alberto Berardi, Caterina Spada, Maria Grazia Capretti, Matilde Ciccia, Maria Rita Pulvirenti, Martina Vezzosi, Fabrizio Sandri
No abstract text is available yet for this article.
2018: Neonatology
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