Saundra S Buys, Edward Partridge, Amanda Black, Christine C Johnson, Lois Lamerato, Claudine Isaacs, Douglas J Reding, Robert T Greenlee, Lance A Yokochi, Bruce Kessel, E David Crawford, Timothy R Church, Gerald L Andriole, Joel L Weissfeld, Mona N Fouad, David Chia, Barbara O'Brien, Lawrence R Ragard, Jonathan D Clapp, Joshua M Rathmell, Thomas L Riley, Patricia Hartge, Paul F Pinsky, Claire S Zhu, Grant Izmirlian, Barnett S Kramer, Anthony B Miller, Jian-Lun Xu, Philip C Prorok, John K Gohagan, Christine D Berg
CONTEXT: Screening for ovarian cancer with cancer antigen 125 (CA-125) and transvaginal ultrasound has an unknown effect on mortality. OBJECTIVE: To evaluate the effect of screening for ovarian cancer on mortality in the Prostate, Lung, Colorectal and Ovarian (PLCO) Cancer Screening Trial. DESIGN, SETTING, AND PARTICIPANTS: Randomized controlled trial of 78,216 women aged 55 to 74 years assigned to undergo either annual screening (n = 39,105) or usual care (n = 39,111) at 10 screening centers across the United States between November 1993 and July 2001...
June 8, 2011: JAMA