Luca Delli Colli, Adnan Al Ali, Sofianne Gabrielli, Marina Delli Colli, Pasquale Mule, Benjamin Lawson, Ann E Clarke, Judy Morris, Jocelyn Gravel, Rod Lim, Edmond S Chan, Ran D Goldman, Andrew O'Keefe, Jennifer Gerdts, Derek K Chu, Julia Upton, Elana Hochstadter, Adam Bretholz, Christine McCusker, Xun Zhang, Shira Benor, Elinor Simons, Elissa M Abrams, Jennifer L P Protudjer, Moshe Ben-Shoshan
BACKGROUND: Epinephrine is the first-line treatment for anaphylaxis but is often replaced with antihistamines or corticosteroids. Delayed epinephrine administration is a risk factor for fatal anaphylaxis. Convincing data on the role of antihistamines and corticosteroids in anaphylaxis management are sparse. OBJECTIVE: To establish the impact of prehospital treatment with epinephrine, antihistamines, and/or corticosteroids on anaphylaxis management. METHODS: Patients presenting with anaphylaxis were recruited prospectively and retrospectively in 10 Canadian and 1 Israeli emergency departments (EDs) between April 2011 and August 2022, as part of the Cross-Canada Anaphylaxis REgistry...
December 2023: Annals of Allergy, Asthma & Immunology