James M Chamberlain, Jaideep Kapur, Shlomo Shinnar, Jordan Elm, Maija Holsti, Lynn Babcock, Alex Rogers, William Barsan, James Cloyd, Daniel Lowenstein, Thomas P Bleck, Robin Conwit, Caitlyn Meinzer, Hannah Cock, Nathan B Fountain, Ellen Underwood, Jason T Connor, Robert Silbergleit
BACKGROUND: Benzodiazepine-refractory, or established, status epilepticus is thought to be of similar pathophysiology in children and adults, but differences in underlying aetiology and pharmacodynamics might differentially affect response to therapy. In the Established Status Epilepticus Treatment Trial (ESETT) we compared the efficacy and safety of levetiracetam, fosphenytoin, and valproate in established status epilepticus, and here we describe our results after extending enrolment in children to compare outcomes in three age groups...
April 11, 2020: Lancet
Alexandre Aranda, Guillaume Foucart, Jean Louis Ducassé, Sabrina Grolleau, Aileen McGonigal, Luc Valton
PURPOSE: Generalized convulsive status epilepticus (GCSE) needs immediate management. Despite guidelines, adherence to management protocols is often poor, this contributing to poor outcome. We aimed to evaluate the usefulness of a management protocol in GCSE. METHODS: This is a prospective population-based study of consecutive adults with GCSE in Haute-Garonne district, France. Demographics and treatment procedures were documented. Factors associated with seizure termination and refractoriness were analyzed using logistic regression...
October 2010: Epilepsia
G D Cascino, D Hesdorffer, G Logroscino, W A Hauser
OBJECTIVE: To investigate the adequacy and efficacy of antiepileptic drug (AED) treatment of nonfebrile status epilepticus (SE). PATIENTS AND METHODS: We performed a population-based retrospective cohort study to evaluate the medical management of SE. Participants included 184 residents of Rochester, Minn, who experienced a first episode of nonfebrile SE between 1965 and 1984. RESULTS: Of the 184 patients, 133 (72.2%) received appropriate, prompt medical treatment for SE, i...
January 2001: Mayo Clinic Proceedings
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