Carmen Rondón, Paloma Campo, Alkis Togias, Wytske J Fokkens, Stephen R Durham, Desmond G Powe, Joaquim Mullol, Miguel Blanca
Local allergic rhinitis (LAR) is a localized nasal allergic response in the absence of systemic atopy characterized by local production of specific IgE (sIgE) antibodies, a T(H)2 pattern of mucosal cell infiltration during natural exposure to aeroallergens, and a positive nasal allergen provocation test response with release of inflammatory mediators (tryptase and eosinophil cationic protein). Although the prevalence remains to be established, a number of patients previously given a diagnosis of nonallergic rhinitis or idiopathic rhinitis are now being classified as having LAR...
June 2012: Journal of Allergy and Clinical Immunology