Matthew W Semler, Jonathan D Casey, Bradley D Lloyd, Pamela G Hastings, Margaret A Hays, Joanna L Stollings, Kevin G Buell, John H Brems, Edward T Qian, Kevin P Seitz, Li Wang, Christopher J Lindsell, Robert E Freundlich, Jonathan P Wanderer, Jin H Han, Gordon R Bernard, Wesley H Self, Todd W Rice
BACKGROUND: Invasive mechanical ventilation in critically ill adults involves adjusting the fraction of inspired oxygen to maintain arterial oxygen saturation. The oxygen-saturation target that will optimize clinical outcomes in this patient population remains unknown. METHODS: In a pragmatic, cluster-randomized, cluster-crossover trial conducted in the emergency department and medical intensive care unit at an academic center, we assigned adults who were receiving mechanical ventilation to a lower target for oxygen saturation as measured by pulse oximetry (Spo2 ) (90%; goal range, 88 to 92%), an intermediate target (94%; goal range, 92 to 96%), or a higher target (98%; goal range, 96 to 100%)...
November 10, 2022: New England Journal of Medicine