Use the collections feature with a free QxMD account.
Use Read by QxMD to access full text via your institution or open access sources.
Read also provides personalized recommendations to keep you up to date in your field.
Existing User
Sign InNew to Read
Sign Up#1
Neal Hermanowicz
Abdominal migraine is often regarded as a childhood disorder and less commonly described in adults. However, gastrointestinal symptoms are known to occur to adult migraine patients, and recognition of adult abdominal migraine may facilitate treatment of the recurrent abdominal symptoms and avoidance of unproductive and sometimes invasive therapies. Here, I describe a patient with chronic migraine headaches and recurrent abdominal pain both of which showed sustained improvement after treatment with onabotulinumtoxinA injections...
September 2021: Case Reports in Neurology
#2
REVIEW
Joshua S Davis, Neta Petersiel, Steven Y C Tong
BACKGROUND: Staphylococcus aureus bloodstream infections are common and associated with a high mortality of 15-25%. Methicillin-resistant S. aureus (MRSA) bloodstream infection accounts for 10-40% of cases, and has an even higher mortality. Despite being the 'bread and butter' of clinical infectious diseases practice, robust evidence to guide optimal management is often lacking and there is wide variation in practice. OBJECTIVES: To provide a real-world example of a case of MRSA bacteraemia and the thought processes of the authors as key management decision points are reached...
February 2022: Clinical Microbiology and Infection
#3
REVIEW
E H G Oei, J Hirvasniemi, T A van Zadelhoff, R A van der Heijden
PURPOSE: To provide a narrative review of original articles on imaging of osteoarthritis (OA) published between January 1, 2020 and March 31, 2021, with a special focus on imaging of inflammation, imaging of bone, cartilage and bone-cartilage interactions, imaging of peri-articular tissues, imaging scoring methods for OA, and artificial intelligence (AI) applied to OA imaging. METHODS: The Embase, Pubmed, Medline, Cochrane databases were searched for original research articles in the English language on human, in vivo, imaging of OA published between January 1, 2020 and March 31, 2021...
February 2022: Osteoarthritis and Cartilage
#4
REVIEW
Marion Voute, Véronique Morel, Gisèle Pickering
Topical lidocaine is widely used in current practice for a variety of pain conditions. This literature review shows that its limited absorption and relative lack of systemic adverse events are an attractive analgesic option for a number of vulnerable patients. Topical lidocaine has been approved by health authorities for the treatment of post-herpetic neuralgia in a number of countries, and studies present some degree of evidence of its efficacy and safety in postsurgical pain, diabetic peripheral neuropathy, carpal tunnel syndrome, chronic lower back pain and osteoarthritis...
2021: Drug Design, Development and Therapy
#5
REVIEW
Emilio Bouza
Multi-drug resistant (MDR) Gram-negative bacteria represent a growing threat, with an increasing prevalence of carbapenem-resistant Enterobacterales (CRE) infections, for which treatment options are limited. New treatment combinations composed of a β-lactam antibiotic plus a potent β-lactamase inhibitor (BLI) with anti-carbapenemase activity have been developed, including two carbapenem/BLI combinations that are commercially available-meropenem/vaborbactam (Vabomere® in the US, Vaborem® in Europe; Melinta Therapeutics) and imipenem/cilastatin/relebactam (Recarbrio®; Merck Sharp & Dohme), plus one other (meropenem/nacubactam) in early clinical development...
November 22, 2021: Journal of Antimicrobial Chemotherapy
#6
REVIEW
Myra H Wyckoff, Eunice M Singletary, Jasmeet Soar, Theresa M Olasveengen, Robert Greif, Helen G Liley, David Zideman, Farhan Bhanji, Lars W Andersen, Suzanne R Avis, Khalid Aziz, Jason C Bendall, David C Berry, Vere Borra, Bernd W Böttiger, Richard Bradley, Janet E Bray, Jan Breckwoldt, Jestin N Carlson, Pascal Cassan, Maaret Castrén, Wei-Tien Chang, Nathan P Charlton, Adam Cheng, Sung Phil Chung, Julie Considine, Daniela T Costa-Nobre, Keith Couper, Katie N Dainty, Peter G Davis, Maria Fernanda de Almeida, Allan R de Caen, Edison F de Paiva, Charles D Deakin, Therese Djärv, Matthew J Douma, Ian R Drennan, Jonathan P Duff, Kathryn J Eastwood, Walid El-Naggar, Jonathan L Epstein, Raffo Escalante, Jorge G Fabres, Joe Fawke, Judith C Finn, Elizabeth E Foglia, Fredrik Folke, Karoline Freeman, Elaine Gilfoyle, Craig A Goolsby, Amy Grove, Ruth Guinsburg, Tetsuo Hatanaka, Mary Fran Hazinski, George S Heriot, Karen G Hirsch, Mathias J Holmberg, Shigeharu Hosono, Ming-Ju Hsieh, Kevin K C Hung, Cindy H Hsu, Takanari Ikeyama, Tetsuya Isayama, Vishal S Kapadia, Mandira Daripa Kawakami, Han-Suk Kim, David A Kloeck, Peter J Kudenchuk, Anthony T Lagina, Kasper G Lauridsen, Eric J Lavonas, Andrew S Lockey, Carolina Malta Hansen, David Markenson, Tasuku Matsuyama, Christopher J D McKinlay, Amin Mehrabian, Raina M Merchant, Daniel Meyran, Peter T Morley, Laurie J Morrison, Kevin J Nation, Michael Nemeth, Robert W Neumar, Tonia Nicholson, Susan Niermeyer, Nikolaos Nikolaou, Chika Nishiyama, Brian J O'Neil, Aaron M Orkin, Osokogu Osemeke, Michael J Parr, Catherine Patocka, Jeffrey L Pellegrino, Gavin D Perkins, Jeffrey M Perlman, Yacov Rabi, Joshua C Reynolds, Giuseppe Ristagno, Charles C Roehr, Tetsuya Sakamoto, Claudio Sandroni, Taylor Sawyer, Georg M Schmölzer, Sebastian Schnaubelt, Federico Semeraro, Markus B Skrifvars, Christopher M Smith, Michael A Smyth, Roger F Soll, Takahiro Sugiura, Sian Taylor-Phillips, Daniele Trevisanuto, Christian Vaillancourt, Tzong-Luen Wang, Gary M Weiner, Michelle Welsford, Jane Wigginton, Jonathan P Wyllie, Joyce Yeung, Jerry P Nolan, Katherine M Berg
The International Liaison Committee on Resuscitation initiated a continuous review of new, peer-reviewed published cardiopulmonary resuscitation science. This is the fifth annual summary of the International Liaison Committee on Resuscitation International Consensus on Cardiopulmonary Resuscitation and Emergency Cardiovascular Care Science With Treatment Recommendations; a more comprehensive review was done in 2020. This latest summary addresses the most recently published resuscitation evidence reviewed by International Liaison Committee on Resuscitation task force science experts...
March 2022: Circulation
#7
REVIEW
Rebeca Muñoz-Rodríguez, Martín Jesús García-González, Pablo Jorge-Pérez, Marta M Martín-Cabeza, Maria Manuela Izquierdo-Gómez, Belén Marí-López, María Amelia Duque-González, Antonio Barragán-Acea, Juan Lacalzada-Almeida
Cardiogenic shock (CS) is associated with a high in-hospital mortality despite the achieved advances in diagnosis and management. Invasive mechanical ventilation and circulatory support constitute the highest step in cardiogenic shock therapy. Once established, taking the decision of weaning from such support is challenging. Intensive care unit (ICU) bedside echocardiography provides noninvasive, immediate, and low-cost monitoring of hemodynamic parameters such as cardiac output, filling pressure, structural disease, congestion status, and device functioning...
October 30, 2021: Journal of Clinical Medicine
#8
REVIEW
Arno Furquim d'Almeida, Erwin Ho, Stijn Van Hees, Thomas Vanwolleghem
Worldwide, over 250 million people are chronically infected with the hepatitis B virus (HBV). Infected patients have an up to 100-fold increased risk for liver-related complications, including cirrhosis, hepatic decompensation and hepatocellular carcinoma. Nonetheless, the majority of the infections remains asymptomatic, stressing the importance of HBV screening and linkage to care. Excellent clinical outcomes are seen during nucleos(t)ide analogue (NA) therapy, which often is continued indefinitively due to a lack of functional cure...
February 2022: United European Gastroenterology Journal
#9
REVIEW
Martha Gulati, Phillip D Levy, Debabrata Mukherjee, Ezra Amsterdam, Deepak L Bhatt, Kim K Birtcher, Ron Blankstein, Jack Boyd, Renee P Bullock-Palmer, Theresa Conejo, Deborah B Diercks, Federico Gentile, John P Greenwood, Erik P Hess, Steven M Hollenberg, Wael A Jaber, Hani Jneid, José A Joglar, David A Morrow, Robert E O'Connor, Michael A Ross, Leslee J Shaw
AIM: This clinical practice guideline for the evaluation and diagnosis of chest pain provides recommendations and algorithms for clinicians to assess and diagnose chest pain in adult patients. METHODS: A comprehensive literature search was conducted from November 11, 2017, to May 1, 2020, encompassing randomized and nonrandomized trials, observational studies, registries, reviews, and other evidence conducted on human subjects that were published in English from PubMed, EMBASE, the Cochrane Collaboration, Agency for Healthcare Research and Quality reports, and other relevant databases...
November 30, 2021: Circulation
#10
JOURNAL ARTICLE
Jonathon Snook, Neeraj Bhala, Ian L P Beales, David Cannings, Chris Kightley, Robert Ph Logan, D Mark Pritchard, Reena Sidhu, Sue Surgenor, Wayne Thomas, Ajay M Verma, Andrew F Goddard
Iron deficiency anaemia (IDA) is a major cause of morbidity and burden of disease worldwide. It can generally be diagnosed by blood testing and remedied by iron replacement therapy (IRT) using the oral or intravenous route. The many causes of iron deficiency include poor dietary intake and malabsorption of dietary iron, as well as a number of significant gastrointestinal (GI) pathologies. Because blood is iron-rich it can result from chronic blood loss, and this is a common mechanism underlying the development of IDA-for example, as a consequence of menstrual or GI blood loss...
November 2021: Gut
#11
REVIEW
Sophie Montgomery, Michael D Miedema, John A Dodson
The value of primary preventative therapies for cardiovascular disease (CVD) in older adults (age ≥75 years) is less certain than in younger patients. There is a lack of quality evidence in older adults due to underenrolment in pivotal trials. While aspirin is no longer recommended for routine use in primary prevention of CVD in older adults, statins may be efficacious. However, it is unclear which patient subgroups may benefit most, and guidelines differ between expert panels. Three relevant geriatric conditions (cognitive impairment, functional impairment and polypharmacy) may influence therapeutic decision making; for example, baseline frailty may affect statin efficacy, and some have advocated for deprescription in this scenario...
June 24, 2022: Heart
#12
REVIEW
Nathan P Wiederhold
Clinicians treating patients with fungal infections may turn to susceptibility testing to obtain information regarding the activity of different antifungals against a specific fungus that has been cultured. These results may then be used to make decisions regarding a patient's therapy. However, for many fungal species that are capable of causing invasive infections, clinical breakpoints have not been established. Thus, interpretations of susceptible or resistant cannot be provided by clinical laboratories, and this is especially true for many molds capable of causing severe mycoses...
November 2021: Open Forum Infectious Diseases
#13
REVIEW
João Pedro Marto, Davide Strambo, Francoise Livio, Patrik Michel
Certain drugs may increase the risk of ischemic stroke (IS). Our goal was to review associations between frequently used drugs and IS. We created an initial list of frequently used drugs to search Pubmed/MEDLINE from 1966 to 2020 and reviewed phase III and IV data, case series, and drug authorities' safety warnings to assess a potential association with IS. Drugs were grouped according to the World Health Organization Anatomical Therapeutic Chemical Classification System. Predefined criteria were applied to establish a level of evidence for an association, from A (high level of evidence of association) to E (high level of evidence of absence of association)...
October 2021: Stroke; a Journal of Cerebral Circulation
#14
JOURNAL ARTICLE
Sonia Huang, Valerie Juniat, Khami Satchi, Liza M Cohen, Garry Davis, Daniel B Rootman, Alan McNab, Dinesh Selva
BACKGROUND: Patients with bilateral lacrimal gland disease are a unique subset of patients where there is a paucity of literature. This presentation often represents systemic disease or malignancy and can cause diagnostic difficulties. We aim to describe the diagnoses and features of bilateral lacrimal gland disease. METHOD: Retrospective multi-centre case series involving 115 patients with bilateral lacrimal gland disease from 1995 to 2020. RESULTS: 115 patients were included...
November 1, 2021: Eye
#15
JOURNAL ARTICLE
Amanda J Berberich, Robert A Hegele
Lipid disorders involving derangements in serum cholesterol, triglycerides, or both are commonly encountered in clinical practice and often have implications for cardiovascular risk and overall health. Recent advances in knowledge, recommendations, and treatment options have necessitated an updated approach to these disorders. Older classification schemes have outlived their usefulness, yielding to an approach based on the primary lipid disturbance identified on a routine lipid panel as a practical starting point...
July 13, 2022: Endocrine Reviews
#16
REVIEW
Maria Makar, Brendan Smyth, Frank Brennan
BACKGROUND: Chronic kidney disease-associated pruritus (CKD-aP), also known as uraemic pruritus, is a disabling symptom for patients and a challenging condition for clinicians. Despite being common amongst end-stage kidney disease (ESKD) patients, it remains underestimated and underdiagnosed. The exact pathogenesis remains largely elusive, which hampers the synthesis of a definite treatment approach. SUMMARY: Chronic pruritus (lasting 6 weeks or more in duration) is a common and potentially disabling symptom in patients with advanced CKD...
2021: Kidney & Blood Pressure Research
#17
REVIEW
Philipp Schuetz, David Seres, Dileep N Lobo, Filomena Gomes, Nina Kaegi-Braun, Zeno Stanga
Disease-related malnutrition in adult patients who have been admitted to hospital is a syndrome associated with substantially increased morbidity, disability, short-term and long-term mortality, impaired recovery from illness, and cost of care. There is uncertainty regarding optimal diagnostic criteria, definitions for malnutrition, and how to identify patients who would benefit from nutritional intervention. Malnutrition has become the focus of research aimed at translating current knowledge of its pathophysiology into improved diagnosis and treatment...
November 20, 2021: Lancet
#18
REVIEW
Piyu Parth Naik
Botulinum toxin (BoNT) is a neurotoxin produced by the Clostridium botulinum bacterium with a well-known efficacy and safety profile in the focal idiopathic hyperhidrosis treatment. BoNT comprises seven different neurotoxins; however, only toxins A and B are clinically employed. BoNT is lately practiced in off-label therapies for a variety of skin diseases. Scar prevention, hyperhidrosis, rhytides, eccrine nevus, alopecia, psoriasis, Darier disease, bullous skin disease, pompholyx and Raynaud's phenomenon are some of the novel indications for BoNT in cosmetic and notably non-cosmetic aspects of dermatology...
2021: Clinical, Cosmetic and Investigational Dermatology
#19
REVIEW
Qingsu Lan, Bing Han, Fengchao Wu, Yu Peng, Zheng Zhang
BACKGROUD: Valsalva maneuver (VM) is a simple and easy method for acute termination of supraventricular tachycardia (SVT), while a postural modification to the VM has been suggested to be superior to the standard VM (SVM). The objective of this meta-analysis is to explore the efficacy and safety of the modified VM (MVM) to terminate SVT compared with the SVM. METHODS: Extensive literature was conducted using the database such as PubMed, Embase, Web of Science, Cochrane library and included randomized controlled trials (RCTs) assessing the efficacy and safety of the MVM and SVM for SVT...
December 2021: American Journal of Emergency Medicine
#20
REVIEW
Chia C Wang, Kimberly A Prather, Josué Sznitman, Jose L Jimenez, Seema S Lakdawala, Zeynep Tufekci, Linsey C Marr
The COVID-19 pandemic has revealed critical knowledge gaps in our understanding of and a need to update the traditional view of transmission pathways for respiratory viruses. The long-standing definitions of droplet and airborne transmission do not account for the mechanisms by which virus-laden respiratory droplets and aerosols travel through the air and lead to infection. In this Review, we discuss current evidence regarding the transmission of respiratory viruses by aerosols-how they are generated, transported, and deposited, as well as the factors affecting the relative contributions of droplet-spray deposition versus aerosol inhalation as modes of transmission...
August 27, 2021: Science
Make the most of Read.
Download the mobile app.
Download the mobile app.
Fetching more papers... 
