Valentina Marchese, Verena Crosato, Maurizio Gulletta, Filippo Castelnuovo, Graziella Cristini, Alberto Matteelli, Francesco Castelli
BACKGROUND: SARS-CoV-2 pandemic has posed formidable public health and clinical challenges. The use of immunosuppressive agents, such as high dose corticosteroids and cytokine inhibitors (e.g., Tocilizumab) has been suggested to contrast the hyperinflammatory process involved in the pathogenesis of the severe disease, with conflicting evidence. Among the drawbacks of immunosuppressive therapy, the risk of reactivation of latent infections, including parasitic infestations, is to be considered...
September 10, 2020: Infection
Audun J Lier, Jessica J Tuan, Matthew W Davis, Nathan Paulson, Dayna McManus, Sheldon Campbell, David R Peaper, Jeffrey E Topal
The SARS-CoV-2 virus has emerged and rapidly evolved into a current global pandemic. Although bacterial and fungal coinfections have been associated with COVID-19, little is known about parasitic infection. We report a case of a COVID-19 patient who developed disseminated strongyloidiasis following treatment with high-dose corticosteroids and tocilizumab. Screening for Strongyloides infection should be pursued in individuals with COVID-19 who originate from endemic regions before initiating immunosuppressive therapy...
October 2020: American Journal of Tropical Medicine and Hygiene
William M Stauffer, Jonathan D Alpern, Patricia F Walker
No abstract text is available yet for this article.
July 30, 2020: JAMA
George Vasquez-Rios, Roberto Pineda-Reyes, Juan Pineda-Reyes, Ricardo Marin, Eloy F Ruiz, Angélica Terashima
Strongyloides stercoralis hyperinfection syndrome (SHS) is a life-threatening condition that warrants early detection and management. We describe the pathogenesis, organ-specific clinical manifestations, and risk factors associated to this condition. A comprehensive review of the literature was conducted in PubMed, LILACS, EBSCO and SciELO by using the keywords: "hyperinfection syndrome"; " Strongyloides stercoralis "; "disseminated strongyloidiasis"; "systemic strongyloidiasis", "pathogenesis" and "pathophysiology"...
June 2019: Journal of Parasitic Diseases: Official Organ of the Indian Society for Parasitology
Priyatam Khadka, Pratap Khadka, Januka Thapaliya, Dhana Bikram Karkee
Introduction: Strongyloidiasis is a neglected tropical disease with global prevalence. Under some cases of immune suppression (especially with corticosteroid administration), the nematode involved disseminates, leading to an amplified, possibly lethal hyper-infection syndrome. Case presentation: A 56-year-old Nepalese man presenting with chief complaints of nausea, vomiting, joint pain and abdominal cramps was admitted to Sumeru Hospital. His past history revealed: chronic obstructive pulmonary disease (COPD), systemic hypertension and previously treated pulmonary tuberculosis...
September 2018: JMM Case Reports
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