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Top Papers for 2020 - Radiatio...
Top Papers for 2020 - Radiation Oncology
• Top Papers for 2020 - Radiation Oncology
#41
RANDOMIZED CONTROLLED TRIAL
Kyu Hye Choi, Sung Ja Ahn, Jae Uk Jeong, Mina Yu, Jin Hee Kim, Bae Kwon Jeong, Joo Hwan Lee, Sung Hwan Kim, Jong Hoon Lee
PURPOSE: To investigate the safety and efficacy of intensity-modulated radiation therapy (IMRT) for early breast cancer compared with 3-dimensional conformal radiotherapy (3D-CRT) in a prospective and randomized trial. METHODS AND MATERIALS: From March 2015 to February 2018, 693 patients with pT1-2N0M0 early breast cancer who underwent breast-conserving surgery were enrolled and randomly assigned into IMRT and 3D-CRT. The primary endpoint was 3-year locoregional recurrence-free survival (LRRFS)...
January 2021: Radiotherapy and Oncology
#42
JOURNAL ARTICLE
Ahmad Ameri, Nazanin Rahnama, Rama Bozorgmehr, Majid Mokhtari, Mohammad Farahbakhsh, Mahmood Nabavi, Simin Dokht Shoaei, Hossein Izadi, Amir Shahram Yousefi Kashi, Hadiseh Shabanpour Dehbaneh, Farzad Taghizadeh-Hesary
PURPOSE: The COVID-19 outbreak is affecting people worldwide. Many infected patients have respiratory involvement that may progress to acute respiratory distress syndrome. This pilot study aimed to evaluate the clinical efficacy of low-dose whole-lung radiation therapy in patients with COVID-19 pneumonia. METHODS AND MATERIALS: In this clinical trial, conducted in Iran, we enrolled patients with COVID-19 who were older than 60 years and hospitalized to receive supplementary oxygen for their documented pneumonia...
December 1, 2020: International Journal of Radiation Oncology, Biology, Physics
#43
JOURNAL ARTICLE
Salman Faruqi, Mark Ruschin, Hany Soliman, Sten Myrehaug, K Liang Zeng, Zain Husain, Eshetu Atenafu, Chia-Lin Tseng, Sunit Das, James Perry, Pejman Maralani, Chris Heyn, Todd Mainprize, Arjun Sahgal
PURPOSE: Limited data exist quantifying the risk of adverse radiation effect (ARE) specific to hypofractionated stereotactic radiosurgery (HSRS). We present our analyses of the risk of ARE after 5 daily fractions of HSRS to surgical cavities and intact metastases. METHODS AND MATERIALS: One hundred and eighty-seven consecutively treated patients with 118 surgical cavities and 132 intact metastases were retrospectively reviewed. All patients were treated with 5 daily fractions with a 2 mm planning target volume applied...
March 15, 2020: International Journal of Radiation Oncology, Biology, Physics
#44
JOURNAL ARTICLE
M Dómine, T Moran, D Isla, J L Martí, I Sullivan, M Provencio, M E Olmedo, S Ponce, A Blasco, M Cobo
Small-cell lung cancer (SCLC) accounts for 15% of lung cancers. Only one-third of patients are diagnosed at limited stage. The median survival remains to be around 15-20 months without significative changes in the strategies of treatment for many years. In stage I and IIA, the standard treatment is the surgery followed by adjuvant therapy with platinum-etoposide. In stage IIB-IIIC, the recommended treatment is early concurrent chemotherapy with platinum-etoposide plus thoracic radiotherapy followed by prophylactic cranial irradiation in patients without progression...
February 2020: Clinical & Translational Oncology
#45
EDITORIAL
Jinoos Yazdany, Alfred H J Kim
Two medications often used for treatment of immune-mediated conditions, hydroxychloroquine and chloroquine, have recently attracted widespread interest as potential therapies for coronavirus disease 2019. The authors of this commentary provide guidance for clinical decision making for patients with coronavirus disease 2019 as well as for patients with rheumatologic conditions, such as systemic lupus erythematosus and rheumatoid arthritis
June 2, 2020: Annals of Internal Medicine
#46
RANDOMIZED CONTROLLED TRIAL
Paul Sargos, Sylvie Chabaud, Igor Latorzeff, Nicolas Magné, Ahmed Benyoucef, Stéphane Supiot, David Pasquier, Menouar Samir Abdiche, Olivier Gilliot, Pierre Graff-Cailleaud, Marlon Silva, Philippe Bergerot, Pierre Baumann, Yazid Belkacemi, David Azria, Meryem Brihoum, Michel Soulié, Pierre Richaud
BACKGROUND: Adjuvant radiotherapy reduces the risk of biochemical progression in prostate cancer patients after radical prostatectomy. We aimed to compare adjuvant versus early salvage radiotherapy after radical prostatectomy, combined with short-term hormonal therapy, in terms of oncological outcomes and tolerance. METHODS: GETUG-AFU 17 was a randomised, open-label, multicentre, phase 3 trial done at 46 French hospitals. Men aged at least 18 years who had an Eastern Cooperative Oncology Group performance status of 1 or less, localised adenocarcinoma of the prostate treated with radical prostatectomy, who had pathologically-staged pT3a, pT3b, or pT4a (with bladder neck invasion), pNx (without pelvic lymph nodes dissection), or pN0 (with negative lymph nodes dissection) disease, and who had positive surgical margins were eligible for inclusion in the study...
October 2020: Lancet Oncology
#47
MULTICENTER STUDY
Chad G Rusthoven, Masaaki Yamamoto, Denise Bernhardt, Derek E Smith, Dexiang Gao, Toru Serizawa, Shoji Yomo, Hitoshi Aiyama, Yoshinori Higuchi, Takashi Shuto, Atsuya Akabane, Yasunori Sato, Ajay Niranjan, Andrew M Faramand, L Dade Lunsford, James McInerney, Leonard C Tuanquin, Brad E Zacharia, Veronica Chiang, Charu Singh, James B Yu, Steve Braunstein, David Mathieu, Charles J Touchette, Cheng-Chia Lee, Huai-Che Yang, Ayal A Aizer, Daniel N Cagney, Michael D Chan, Douglas Kondziolka, Kenneth Bernstein, Joshua S Silverman, Inga S Grills, Zaid A Siddiqui, Justin C Yuan, Jason P Sheehan, Diogo Cordeiro, Kename Nosaki, Takahashi Seto, Christopher P Deibert, Vivek Verma, Samuel Day, Lia M Halasz, Ronald E Warnick, Daniel M Trifiletti, Joshua D Palmer, Albert Attia, Benjamin Li, Christopher P Cifarelli, Paul D Brown, John A Vargo, Stephanie E Combs, Kerstin A Kessel, Stefan Rieken, Samir Patel, Matthias Guckenberger, Nicolaus Andratschke, Brian D Kavanagh, Tyler P Robin
Importance: Although stereotactic radiosurgery (SRS) is preferred for limited brain metastases from most histologies, whole-brain radiotherapy (WBRT) has remained the standard of care for patients with small cell lung cancer. Data on SRS are limited. Objective: To characterize and compare first-line SRS outcomes (without prior WBRT or prophylactic cranial irradiation) with those of first-line WBRT. Design, Setting, and Participants: FIRE-SCLC (First-line Radiosurgery for Small-Cell Lung Cancer) was a multicenter cohort study that analyzed SRS outcomes from 28 centers and a single-arm trial and compared these data with outcomes from a first-line WBRT cohort...
July 1, 2020: JAMA Oncology
#48
REVIEW
Rafael de Cabo, Mark P Mattson
New England Journal of Medicine, Volume 381, Issue 26, Page 2541-2551, December 2019.
December 26, 2019: New England Journal of Medicine
#49
EDITORIAL
Abram Recht
No abstract text is available yet for this article.
November 1, 2020: Journal of Clinical Oncology
#50
JOURNAL ARTICLE
Eric J Lehrer, Amar U Kishan, James B Yu, Daniel M Trifiletti, Timothy N Showalter, Rodney Ellis, Nicholas G Zaorsky
INTRODUCTION: To characterize the efficacy (5-year disease-free survival [DFS]) and safety (incidence of grade 2+ late gastrointestinal or genitourinary toxicity) of ultrahypofractionated radiation therapy (UHRT) versus hypofractionated radiation therapy (HFRT) and conventionally fractionated radiation therapy (CFRT) by comparing patients treated on phase III protocols. METHODS: A PICOS/PRISMA/MOOSE protocol was used to identify eligible studies. Weighted random effects meta-analyses were conducted using the DerSimonian and Laird method...
July 2020: Radiotherapy and Oncology
#51
REVIEW
Mylin A Torres, Kathleen C Horst, Gary M Freedman
No abstract text is available yet for this article.
July 10, 2020: Journal of Clinical Oncology
#52
JOURNAL ARTICLE
Charlotte L Brouwer, Roel J H M Steenbakkers, Jean Bourhis, Wilfried Budach, Cai Grau, Vincent Grégoire, Marcel van Herk, Anne Lee, Philippe Maingon, Chris Nutting, Brian O'Sullivan, Sandro V Porceddu, David I Rosenthal, Nanna M Sijtsema, Johannes A Langendijk
PURPOSE: The objective of this project was to define consensus guidelines for delineating organs at risk (OARs) for head and neck radiotherapy for routine daily practice and for research purposes. METHODS: Consensus guidelines were formulated based on in-depth discussions of a panel of European, North American, Asian and Australian radiation oncologists. RESULTS: Twenty-five OARs in the head and neck region were defined with a concise description of their main anatomic boundaries...
October 2015: Radiotherapy and Oncology
#53
F Cardoso, S Paluch-Shimon, E Senkus, G Curigliano, M S Aapro, F André, C H Barrios, J Bergh, G S Bhattacharyya, L Biganzoli, F Boyle, M-J Cardoso, L A Carey, J Cortés, N S El Saghir, M Elzayat, A Eniu, L Fallowfield, P A Francis, K Gelmon, J Gligorov, R Haidinger, N Harbeck, X Hu, B Kaufman, R Kaur, B E Kiely, S-B Kim, N U Lin, S A Mertz, S Neciosup, B V Offersen, S Ohno, O Pagani, A Prat, F Penault-Llorca, H S Rugo, G W Sledge, C Thomssen, D A Vorobiof, T Wiseman, B Xu, L Norton, A Costa, E P Winer
No abstract text is available yet for this article.
December 2020: Annals of Oncology: Official Journal of the European Society for Medical Oncology
#54
JOURNAL ARTICLE
Emma M Dunne, Arjun Sahgal, Simon S Lo, Alanah Bergman, Robert Kosztyla, Nicolas Dea, Eric L Chang, Ung-Kyu Chang, Samuel T Chao, Salman Faruqi, Amol J Ghia, Kristin J Redmond, Scott G Soltys, Mitchell C Liu
BACKGROUND AND PURPOSE: To interrogate inter-observer variability in gross tumour volume (GTV) and clinical target volume (CTV) delineation specific to the treatment of sacral metastases with spinal stereotactic body radiation therapy (SBRT) and develop CTV consensus contouring recommendations. MATERIALS AND METHODS: Nine specialists with spinal SBRT expertise representing 9 international centres independently contoured the GTV and CTV for 10 clinical cases of metastatic disease within the sacrum...
April 2020: Radiotherapy and Oncology
#55
RANDOMIZED CONTROLLED TRIAL
Icro Meattini, Livia Marrazzo, Calogero Saieva, Isacco Desideri, Vieri Scotti, Gabriele Simontacchi, Pierluigi Bonomo, Daniela Greto, Monica Mangoni, Silvia Scoccianti, Sara Lucidi, Lisa Paoletti, Massimiliano Fambrini, Marco Bernini, Luis Sanchez, Lorenzo Orzalesi, Jacopo Nori, Simonetta Bianchi, Stefania Pallotta, Lorenzo Livi
PURPOSE: To report the long-term results of external-beam accelerated partial-breast irradiation (APBI) intensity-modulated radiation therapy (IMRT) Florence phase III trial comparing whole-breast irradiation (WBI) to APBI in early-stage breast cancer. PATIENTS AND METHODS: The primary end point was to determine the 5-year difference in ipsilateral breast tumor recurrence (IBTR) between 30 Gy in 5 once-daily fractions (APBI arm) and 50 Gy in 25 fractions with a tumor bed boost (WBI arm) after breast-conserving surgery...
December 10, 2020: Journal of Clinical Oncology
#56
REVIEW
Michael T Milano, Jimm Grimm, Andrzej Niemierko, Scott G Soltys, Vitali Moiseenko, Kristin J Redmond, Ellen Yorke, Arjun Sahgal, Jinyu Xue, Anand Mahadevan, Alexander Muacevic, Lawrence B Marks, Lawrence R Kleinberg
PURPOSE: As part of the American Association of Physicists in Medicine Working Group on Stereotactic Body Radiotherapy investigating normal tissue complication probability (NTCP) after hypofractionated radiation therapy, data from published reports (PubMed indexed 1995-2018) were pooled to identify dosimetric and clinical predictors of radiation-induced brain toxicity after single-fraction stereotactic radiosurgery (SRS) or fractionated stereotactic radiosurgery (fSRS). METHODS AND MATERIALS: Eligible studies provided NTCPs for the endpoints of radionecrosis, edema, or symptoms after cranial SRS/fSRS and quantitative dose-volume metrics...
May 1, 2021: International Journal of Radiation Oncology, Biology, Physics
#57
JOURNAL ARTICLE
Sandro V Porceddu, Christopher Daniels, Sue S Yom, Howard Liu, John Waldron, Vincent Gregoire, Alisha Moore, Michael Veness, Min Yao, Jorgen Johansen, Hisham Mehanna, Danny Rischin, Quynh-Thu Le
Radiation therapy (RT) consensus contouring guidelines in the postoperative setting for complex cutaneous squamous cell carcinoma of the head and neck have been developed by expert clinicians in the field of head and neck and dermato-oncology and members of the Head and Neck Cancer International Group to assist radiation oncologists involved in the management of this disease. These guidelines present a set of principles used to define postoperative RT volumes and corresponding minimum doses after resection of all macroscopic tumor with or without microscopic residual disease...
July 15, 2020: International Journal of Radiation Oncology, Biology, Physics
#58
JOURNAL ARTICLE
Ellie Maghami, Nofisat Ismaila, Adriana Alvarez, Rebecca Chernock, Umamaheswar Duvvuri, Jessica Geiger, Neil Gross, Bruce Haughey, Doru Paul, Cristina Rodriguez, David Sher, Hilda E Stambuk, John Waldron, Matt Witek, James Caudell
PURPOSE: To provide evidence-based recommendations to practicing physicians and other health care providers on the diagnosis and management of squamous cell carcinoma of unknown primary in the head and neck (SCCUP). METHODS: The American Society of Clinical Oncology convened an Expert Panel of medical oncology, surgery, radiation oncology, radiology, pathology, and advocacy experts to conduct a literature search, which included systematic reviews, meta-analyses, randomized controlled trials, and prospective and retrospective comparative observational studies published from 2008 through 2019...
August 1, 2020: Journal of Clinical Oncology
#59
COMPARATIVE STUDY
Matthew G Parry, Julie Nossiter, Thomas E Cowling, Arunan Sujenthiran, Brendan Berry, Paul Cathcart, Noel W Clarke, Heather Payne, Jan van der Meulen, Ajay Aggarwal
PURPOSE: Little is known about the toxicity of additional pelvic lymph node irradiation in men receiving intensity modulated radiation therapy (IMRT) for prostate cancer. The aim of this study was to compare patient-reported outcomes after IMRT to the prostate only (PO-IMRT) versus the prostate and pelvic lymph nodes (PPLN-IMRT). METHODS AND MATERIALS: Patients who received a diagnosis of high-risk or locally advanced prostate cancer in the English National Health Service between April 2014 and September 2016 who were treated with IMRT were mailed a questionnaire at least 18 months after diagnosis...
December 1, 2020: International Journal of Radiation Oncology, Biology, Physics
#60
JOURNAL ARTICLE
Diana Lin, Kaitlyn Lapen, Michael V Sherer, Jolie Kantor, Zhigang Zhang, Lindsay M Boyce, Walter Bosch, Deborah Korenstein, Erin F Gillespie
PURPOSE: Clinical trials have described variation in radiation therapy plan quality, of which contour delineation is a key component, and linked this to inferior patient outcomes. In response, consensus guidelines have been developed to standardize contour delineation. This investigation assesses trends in contouring guidelines and examines the methodologies used to generate and deliver recommendations. METHODS AND MATERIALS: We conducted a literature search for contouring guidelines published after 1995...
July 15, 2020: International Journal of Radiation Oncology, Biology, Physics
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