Johannes Grosse, Helen Heffron, Keith Burling, Mohammed Akhter Hossain, Abdella M Habib, Gareth J Rogers, Paul Richards, Rachel Larder, Debra Rimmington, Alice A Adriaenssens, Laura Parton, Justin Powell, Matteo Binda, William H Colledge, Joanne Doran, Yukio Toyoda, John D Wade, Samuel Aparicio, Mark B L Carlton, Anthony P Coll, Frank Reimann, Stephen O'Rahilly, Fiona M Gribble
The gut endocrine system is emerging as a central player in the control of appetite and glucose homeostasis, and as a rich source of peptides with therapeutic potential in the field of diabetes and obesity. In this study we have explored the physiology of insulin-like peptide 5 (Insl5), which we identified as a product of colonic enteroendocrine L-cells, better known for their secretion of glucagon-like peptide-1 and peptideYY. i.p. Insl5 increased food intake in wild-type mice but not mice lacking the cognate receptor Rxfp4...
July 29, 2014: Proceedings of the National Academy of Sciences of the United States of America