Takaoki Yokochi, Takahito Takeuchi, Jumpei Mukai, Yukihiro Akita, Kojiro Nagai, Keizo Obu, Tatsuyuki Kakuma, Toyojiro Matsuishi
INTRODUCTION: Acute encephalopathy with biphasic seizures and late reduced diffusion (AESD) is the most common subtype of acute encephalopathy among children in Japan. The pathogenesis of AESD is mostly delayed cerebral edema caused by excitotoxic injury. It is difficult to discriminate AESD and complex febrile seizure in the early phase. Many cases have neurologic sequelae because early intervention is difficult. METHODS: To establish an early diagnostic method, we assessed 213 hospitalized cases of febrile status epilepticus (FSE) between January 2004 and August 2014...
February 2016: Brain & Development
Mohammad Reza Sharif, Davood Kheirkhah, Mahla Madani, Hamed Haddad Kashani
INTRODUCTION: Febrile seizure is among the most common convulsion disorders in children, which strikes 2% to 5% of children between 3 to 60 months of age. Some studies have reported that iron deficiency could be a risk factor for febrile seizure. The present study was conducted to compare the rate of iron deficiency anemia in febrile children with and without seizure. MATERIALS AND METHODS: This case-control study evaluated 200 children aged 6-60 month in two 100 person groups (febrile seizure and febrile without convulsion) in Kashan...
June 25, 2015: Global Journal of Health Science
Razieh Fallah, Saeideh Sabbaghzadegan, Sedighah Akhavan Karbasi, Fariba Binesh
OBJECTIVE: Serum zinc level might be related to pathogenesis of febrile seizure (FS). The purpose of this study was to evaluate efficacy and safety of oral zinc supplementation on FS recurrence prevention in non-zinc-deficient children. MATERIALS AND METHODS: In a randomized clinical study, one hundred 18 to 60 mo old children with normal zinc level with first simple FS were referred to Shahid Sadoughi Hospital, Yazd, Iran from May 2012 to June 2013, were randomly assigned to two groups to receive 2 mg/kg/d zinc sulfate for six consecutive months or placebo as control group and were followed up for 1 y for FS recurrence...
2015: Nutrition
Yvonne W Wu, Joseph Sullivan, Sharon S McDaniel, Miriam H Meisler, Eileen M Walsh, Sherian Xu Li, Michael W Kuzniewicz
OBJECTIVE: De novo mutations of the gene sodium channel 1α (SCN1A) are the major cause of Dravet syndrome, an infantile epileptic encephalopathy. US incidence of DS has been estimated at 1 in 40 000, but no US epidemiologic studies have been performed since the advent of genetic testing. METHODS: In a retrospective, population-based cohort of all infants born at Kaiser Permanente Northern California during 2007-2010, we electronically identified patients who received ≥2 seizure diagnoses before age 12 months and who were also prescribed anticonvulsants at 24 months...
November 2015: Pediatrics
Michael S Hildebrand, A Marie Phillips, Saul A Mullen, Paul A Adlard, Katia Hardies, John A Damiano, Verena Wimmer, Susannah T Bellows, Jacinta M McMahon, Rosemary Burgess, Rik Hendrickx, Sarah Weckhuysen, Arvid Suls, Peter De Jonghe, Ingrid E Scheffer, Steven Petrou, Samuel F Berkovic, Christopher A Reid
Febrile seizures (FS) are the most common seizure syndrome and are potentially a prelude to more severe epilepsy. Although zinc (Zn(2+)) metabolism has previously been implicated in FS, whether or not variation in proteins essential for Zn(2+) homeostasis contributes to susceptibility is unknown. Synaptic Zn(2+) is co-released with glutamate and modulates neuronal excitability. SLC30A3 encodes the zinc transporter 3 (ZNT3), which is primarily responsible for moving Zn(2+) into synaptic vesicles. Here we sequenced SLC30A3 and discovered a rare variant (c...
December 9, 2015: Scientific Reports
Elizabeth L Alford, James W Wheless, Stephanie J Phelps
Generalized convulsive status epilepticus (GCSE) is one of the most common neurologic emergencies and can be associated with significant morbidity and mortality if not treated promptly and aggressively. Management of GCSE is staged and generally involves the use of life support measures, identification and management of underlying causes, and rapid initiation of anticonvulsants. The purpose of this article is to review and evaluate published reports regarding the treatment of impending, established, refractory, and super-refractory GCSE in pediatric patients...
2015: Journal of Pediatric Pharmacology and Therapeutics: JPPT: the Official Journal of PPAG
Richard Fm Chin, Omotomilola Ajetunmobi, Christopher J Weir, Rachael Wood
AIM: UK guidelines do not recommend prescribing emergency antiepileptic drugs after first simple febrile seizures or for single afebrile seizures. Non-adherence to the guidelines could result in substantial health service cost. METHODS: Scottish national hospital discharge records were used to identify children aged one month to 4 years admitted for a first febrile seizures or single afebrile seizures between April 2009 and March 2012. Prescriptions for antiepileptic drugs within 12 months of index admission were identified on the national community prescribing database by matching unique patient identifiers...
June 2015: Epileptic Disorders: International Epilepsy Journal with Videotape
Peter Camfield, Carol Camfield
To review the literature about febrile seizures and GEFS plus with special emphasis on management and outcome. Selected literature review. Febrile seizures are the most common convulsive event in humans, occurring in 2-6% of the population. The aetiology is complex with strong evidence for a heterogeneous genetic predisposition interacting with fever of any cause, with certain viral infections having a greater effect. A large amount of literature has established that febrile seizures have no long-term consequences on cognition or behaviour...
June 2015: Epileptic Disorders: International Epilepsy Journal with Videotape
Amir A Kimia, Richard G Bachur, Alcy Torres, Marvin B Harper
PURPOSE OF REVIEW: The review describes current evidence on the evaluation of febrile seizures in the acute setting, the need for further outpatient assessment, and predictors regarding long-term outcomes of these patients. RECENT FINDINGS: New evidence has been added in support of limited assessment and intervention: evidence on low utility of lumbar puncture, emergent neuroimaging, and follow-up electroencephalography, as well as low yield for antipyretic prophylaxis and intermittent use of antiepileptic drugs...
June 2015: Current Opinion in Pediatrics
Masahiro Nishiyama, Hiroaki Nagase, Tsukasa Tanaka, Kyoko Fujita, Azusa Maruyama, Daisaku Toyoshima, Taku Nakagawa, Mariko Taniguchi-Ikeda, Ichiro Morioka, Naoya Morisada, Satoshi Takada, Kazumoto Iijima
BACKGROUND: Convulsive status epilepticus with fever is common and may be related to neurological sequela in children. However, there are limited data on the demographics and risk factors of this phenomenon. Thus, we aimed to describe the demographics and risk factors of neurological sequela among children with convulsive status epilepticus with fever. METHODS: We reviewed convulsive status epilepticus with fever cases in the pediatric intensive care unit at Kobe Children's Hospital between 2002 and 2013...
May 2015: Pediatric Neurology
Ayşe Kartal, Ayşegül Neşe Çıtak Kurt, Tuğba Hirfanoğlu, Kürşad Aydın, Ayşe Serdaroğlu
Subacute sclerosing panencephalitis (SSPE) is a devastating disease of the central nervous system (CNS) caused by persistent mutant measles virus infection. The diagnosis of SSPE is based on characteristic clinical and EEG findings and demonstration of elevated antibody titres against measles in cerebrospinal fluid. Subacute sclerosing panencephalitis can have atypical clinical features at the onset. Herein, we report an unusual case of subacute sclerosing panencephalitis in a child with recurrent febrile seizures...
2015: Case Reports in Pediatrics
Mohammad Mehdi Nasehi, Roya Sakhaei, Mahmood Moosazadeh, Maryam Aliramzany
OBJECTIVE: Several factors are involved in the etiology of febrile seizure (FS), among them is zinc (Zn), which has been discussed in various studies. The present systematic review compares Zn levels in children with FS and a control group. MATERIALS & METHODS: We searched keywords of febrile seizure, febrile convulsion, children, childhood, fever, trace elements, risk factor, predisposing, zinc, Zn, and epilepsy in the following databases: SCOPUS, PubMed, and Google Scholar...
2015: Iranian Journal of Child Neurology
S Sattar, S K Saha, F Parveen, L A Banu, A Momen, A U Ahmed, M R Quddush, M M Karim, S A Begum, M A Haque, M R Hoque
Febrile seizures are the most common type of seizure among children that can be prevented by using prophylactic drugs like Clobazam and Diazepam. The present prospective study was conducted in the Department of Pediatrics, Mymensingh Medical College Hospital and Community Based Medical College Hospital, Bangladesh over a period of 1 year from July 2012 to June 2013 to compare the effectiveness of intermittent Clobazam versus Diazepam therapy in preventing the recurrence of febrile seizures and assessed adverse effects of each drug...
October 2014: Mymensingh Medical Journal: MMJ
Hitoshi Ueda, Hitoshi Tajiri, Sadami Kimura, Yuri Etani, Gaku Hosoi, Tomoko Maruyama, Haruyoshi Noma, Yoshio Kusumoto, Tomoko Takano, Yoshiko Baba, Toshizaburo Nagai
OBJECTIVE: We analyzed the clinical features of seizures during gastroenteritis in children by comparing the norovirus and rotavirus pathogen, and the impact of fever, if present, during the seizure episodes. METHODS: Retrospective analysis was performed on 293 consecutive pediatric patients admitted with viral gastroenteritis to Osaka General Hospital between November 2007 and May 2009. Eighteen patients developed seizures, 12 of whom were positive for norovirus and six for rotavirus, as revealed by antigen detection...
January 2015: Epilepsy Research
Claudia Passamonti, Cristina Petrelli, Davide Mei, Nicoletta Foschi, Renzo Guerrini, Leandro Provinciali, Nelia Zamponi
We report a three-generation, clinically heterogeneous family in which we identify a novel inherited splicing mutation of the SCN1A gene. Thirteen subjects were submitted to genetic analysis, clinical and instrumental examination, and neuropsychological assessment. In eight subjects, a heterozygous c.2946+5G>A donor splice site alteration in the SCN1A gene was found. Half of them had never had a seizure and showed normal EEG and cognitive profile, whereas the other half had a history of seizures and variable neuropsychological impairments ranging from moderate cognitive disabilities to mild visual-motor impairments...
February 2015: Epilepsy & Behavior: E&B
Ellen V S Hessel, Marina de Wit, Inge G Wolterink-Donselaar, Henk Karst, Esther de Graaff, Hein A van Lith, Ewart de Bruijn, Sophietje de Sonnaville, Nienke E Verbeek, Dick Lindhout, Carolien G F de Kovel, Bobby P C Koeleman, Marjan van Kempen, Eva Brilstra, Edwin Cuppen, Maarten Loos, Sabine S Spijker, Anne A Kan, Susanne E Baars, Peter C van Rijen, Peter H Gosselaar, Marian J A Groot Koerkamp, Frank C P Holstege, Cornelia van Duijn, Jeanette Vergeer, Henriette A Moll, Erik Taubøll, Kjell Heuser, Geert M J Ramakers, R Jeroen Pasterkamp, Onno van Nieuwenhuizen, Casper C Hoogenraad, Martien J H Kas, Pierre N E de Graan
OBJECTIVE: Febrile seizures (FS) are the most common seizure type in young children. Complex FS are a risk factor for mesial temporal lobe epilepsy (mTLE). To identify new FS susceptibility genes we used a forward genetic strategy in mice and subsequently analyzed candidate genes in humans. METHODS: We mapped a quantitative trait locus (QTL1) for hyperthermia-induced FS on mouse chromosome 1, containing the signal recognition particle 9 (Srp9) gene. Effects of differential Srp9 expression were assessed in vivo and in vitro...
April 2014: Annals of Clinical and Translational Neurology
Abolfazl Mahyar, Parviz Ayazi, Reza Orangpour, Mohammad Mahdi Daneshi-Kohan, Mohammad Reza Sarokhani, Amir Javadi, Morteza Habibi, Mousa Talebi-Bakhshayesh
PURPOSE: Febrile seizures are induced by fever and are the most common type of seizures in children. Although numerous studies have been performed on febrile seizures, their pathophysiology remains unclear. Recent studies have shown that cytokines may play a role in the pathogenesis of febrile seizures. The present study was conducted to identify potential links between serum interleukin-1beta (IL-1β), tumor necrosis factor-alpha (TNF-α), and febrile seizures. METHODS: Ninety-two patients with simple or complex febrile seizures (46 patients per seizure type), and 46 controls with comparable age, sex, and severity of temperature were enrolled...
October 2014: Korean Journal of Pediatrics
Lin-Yan Hu, Li-Ping Zou, Jian-Min Zhong, Lei Gao, Jian-Bo Zhao, Nong Xiao, Hong Zhou, Meng Zhao, Xiu-Yu Shi, Yu-Jie Liu, Jun Ju, Wei-Na Zhang, Xiao-Fan Yang, Patrick Kwan
OBJECTIVE: Febrile seizure (FS) is the most common form of childhood seizure disorders. FS is perhaps one of the most frequent causes of admittance to pediatric emergency wards worldwide. We aimed to identify a new, safe, and effective therapy for preventing FS recurrence. METHODS: A total of 115 children with a history of two or more episodes of FS were randomly assigned to levetiracetam (LEV) and control (LEV/control ratio = 2:1) groups. At the onset of fever, LEV group was orally administered with a dose of 15-30 mg/kg per day twice daily for 1 week...
March 2014: Annals of Clinical and Translational Neurology
Acharaporn Maksikharin, Olarn Prommalikit
BACKGROUND: Febrile seizures recur within 24 hours in around 16% of children. Some studies have demonstrated a significant correlation between serum sodium levels and recurrent febrile seizures. AIM: To investigate whether the serum sodium level predicts recurrence of febrile seizures within 24 hours. METHODS: The study was undertaken in children with febrile seizures in the period from January 2007 to December 2011. Retrospective data collected from medical records included age, gender, family history of febrile seizures, body temperature, duration of recognised fever and serum sodium levels...
February 2015: Paediatrics and International Child Health
Rod C Scott
Convulsive status epilepticus is the most common neurological emergency in children and is associated with significant morbidity and mortality. The morbidities include later development of epilepsy, cognitive impairment, and psychiatric impairments. There has been a long-standing hypothesis that these outcomes are, at least in part, a function of brain injury induced by the status epilepticus. There is evidence from animal models and prospective human studies that the hippocampus may be injured during febrile status epilepticus although this pathophysiological sequence remains uncommon...
October 2014: Epileptic Disorders: International Epilepsy Journal with Videotape
2014-10-25 19:44:03
Fetch more papers »
Fetching more papers... Fetching...
Remove bar
Read by QxMD icon Read

Save your favorite articles in one place with a free QxMD account.


Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"

We want to hear from doctors like you!

Take a second to answer a survey question.