Robert Hämmig, Wilfried Köhler, Karin Bonorden-Kleij, Bernd Weber, Karin Lebentrau, Toni Berthel, Lucija Babic-Hohnjec, Christian Vollmert, Doris Höpner, Najibulah Gholami, Uwe Verthein, Christian Haasen, Jens Reimer, Christian Ruckes
Opioid substitution treatment (OST) for opioid dependence may be limited by adverse events (AEs). Increasing the range of therapeutic options optimizes outcomes and facilitates patient management. An international, multi-center, two-phase study investigated the efficacy and safety of slow-release oral morphine (SROM) versus methadone in patients receiving methadone therapy for opioid dependence. In phase 1 (two way cross-over, 11 weeks each period) patients were randomized to SROM or methadone oral solution...
October 2014: Journal of Substance Abuse Treatment