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RANDOMIZED CONTROLLED TRIAL
Gary Wittert, Karen Bracken, Kristy P Robledo, Mathis Grossmann, Bu B Yeap, David J Handelsman, Bronwyn Stuckey, Ann Conway, Warrick Inder, Robert McLachlan, Carolyn Allan, David Jesudason, Mark Ng Tang Fui, Wendy Hague, Alicia Jenkins, Mark Daniel, Val Gebski, Anthony Keech
BACKGROUND: Men who are overweight or obese frequently have low serum testosterone concentrations, which are associated with increased risk of type 2 diabetes. We aimed to determine whether testosterone treatment prevents progression to or reverses early type 2 diabetes, beyond the effects of a community-based lifestyle programme. METHODS: T4DM was a randomised, double-blind, placebo-controlled, 2-year, phase 3b trial done at six Australian tertiary care centres...
January 2021: Lancet Diabetes & Endocrinology
#2
REVIEW
Renée L Mulder, Anna Font-Gonzalez, Daniel M Green, Erik A H Loeffen, Melissa M Hudson, Jacqueline Loonen, Richard Yu, Jill P Ginsberg, Rod T Mitchell, Julianne Byrne, Roderick Skinner, Antoinette Anazodo, Louis S Constine, Andrica de Vries, Kirsi Jahnukainen, Armando Lorenzo, Andreas Meissner, Leena Nahata, Marij Dinkelman-Smit, Herman Tournaye, Riccardo Haupt, Marry M van den Heuvel-Eibrink, Hanneke M van Santen, Ans M M van Pelt, Uta Dirksen, Jaap den Hartogh, Eline van Dulmen-den Broeder, W Hamish Wallace, Jennifer Levine, Wim J E Tissing, Leontien C M Kremer, Lisa B Kenney, Marianne D van de Wetering
Male patients with childhood, adolescent, and young adult cancer are at an increased risk for infertility if their treatment adversely affects reproductive organ function. Future fertility is a primary concern of patients and their families. Variations in clinical practice are barriers to the timely implementation of interventions that preserve fertility. As part of the PanCareLIFE Consortium, in collaboration with the International Late Effects of Childhood Cancer Guideline Harmonization Group, we reviewed the current literature and developed a clinical practice guideline for fertility preservation in male patients who are diagnosed with childhood, adolescent, and young adult cancer at age 25 years or younger, including guidance on risk assessment and available methods for fertility preservation...
February 2021: Lancet Oncology
#3
REVIEW
Renée L Mulder, Anna Font-Gonzalez, Eline van Dulmen-den Broeder, Gwendolyn P Quinn, Jill P Ginsberg, Erik A H Loeffen, Melissa M Hudson, Karen C Burns, Hanneke M van Santen, Claire Berger, Tamara Diesch, Uta Dirksen, Aleksander Giwercman, Clarisa Gracia, Sarah E Hunter, Joanne F Kelvin, James L Klosky, Joop S E Laven, Barbara A Lockart, Sebastian J C M M Neggers, Michelle Peate, Bob Phillips, Damon R Reed, Eva Maria E Tinner, Julianne Byrne, Margreet Veening, Marleen van de Berg, Chris M Verhaak, Antoinette Anazodo, Kenny Rodriguez-Wallberg, Marry M van den Heuvel-Eibrink, Ogechukwu A Asogwa, Alexandra Brownsdon, W Hamish Wallace, Daniel M Green, Roderick Skinner, Riccardo Haupt, Lisa B Kenney, Jennifer Levine, Marianne D van de Wetering, Wim J E Tissing, Norbert W Paul, Leontien C M Kremer, Julia Inthorn
Patients with childhood, adolescent, and young adult cancer who will be treated with gonadotoxic therapies are at increased risk for infertility. Many patients and their families desire biological children but effective communication about treatment-related infertility risk and procedures for fertility preservation does not always happen. The PanCareLIFE Consortium and the International Late Effects of Childhood Cancer Guideline Harmonization Group reviewed the literature and developed a clinical practice guideline that provides recommendations for ongoing communication methods for fertility preservation for patients who were diagnosed with childhood, adolescent, and young adult cancer at age 25 years or younger and their families...
February 2021: Lancet Oncology
#4
REVIEW
Quinn C Rainer, Alejandro A Rodriguez, Petar Bajic, Anat Galor, Ranjith Ramasamy, Thomas A Masterson
A common characteristic of Peyronie's Disease (PD) is plaque calcification, which is associated with decreased response to treatments and higher rates of surgical intervention. Despite its prevalence in the PD population, the literature on plaque calcification is limited. While the diagnosis of PD is mostly clinical, imaging modalities such as ultrasound can be used to identify plaque calcification. The proper identification of plaque calcification is crucial for guiding management and setting therapeutic expectations for patients with PD...
June 2021: Urology
#5
REVIEW
Rachel A Mann, Khushabu Kasabwala, Nicholas Kim, Joseph J Pariser
Penile inversion vaginoplasty is the most common technique used for gender affirming genital surgery in the treatment of gender dysphoria among transwomen. As vaginoplasty becomes more widely available, the management of associated complications has become its own field. There is a relative dearth of literature on surgery for complications following vaginoplasty. This review illustrates surgical technique and management options for patient reported complaints and complications following vaginoplasty. The goal of this manuscript is two-fold (1) to introduce community surgeons to common post-operative issues they may encounter and (2) provide a systematic operative approach to complications for reconstructive surgeons who see transgender patients regularly...
January 22, 2021: Urology
#6
JOURNAL ARTICLE
Arihant Mehta, Whei Chang Kim, Karam Ghazal Aswad, Oliver Brunckhorst, Hashim U Ahmed, Kamran Ahmed
To determine the effect of prostate biopsy on erectile function we conducted a systematic review and meta-analysis up to August 2020. Mean difference of International Index of Erectile Function-5 compared to baseline scores were pooled at 1, 3 and 6-months using a random effect model. Of 47 full text articles identified, 7 were included in the meta-analysis. A significant reduction in mean IIEF5 of 4.61 (0.32-8.91, P= .04) was found at 1-month post biopsy. This resolved with non-significant differences at 3- and 6-months post procedure...
September 2021: Urology
#7
JOURNAL ARTICLE
Daniel Mønsted Shabanzadeh, Signe Clausen, Katrine Maigaard, Mikkel Fode
OBJECTIVE: To determine the risk of complications requiring treatment following male circumcision by health-care professionals and to explore the impact of participant characteristics, type of circumcision and study design. METHODS: We identified studies through systematic searches in online databases (MEDLINE, EMBASE and CENTRAL) and hand searches. We performed random-effects meta-analysis to determine risk of circumcision complications and mixed-effects metaregression analyses to explore the impact of participant characteristics, type of circumcision and study design...
June 2021: Urology
#8
JOURNAL ARTICLE
Johnathan Doolittle, Jagan Kansal, Peter Dietrich, Sarah Brink, Michael McNamara, Andrea Moyer, Robert Medairos, Jay Sandlow
OBJECTIVE: To determine the impact of transitioning from opioid to non-opioid analgesia post-vasectomy on unplanned opioid prescriptions and health encounters. METHODS: A retrospective review for patients who underwent vasectomy from October 2018 through December 2019 was performed. Beginning February 1st , 2019, patients were counseled to take scheduled acetaminophen and ibuprofen in lieu of acetaminophen with codeine, with an opioid prescription only provided upon request...
August 2021: Urology
#9
REVIEW
Fares Kosseifi, Ala Chebbi, Nehme Raad, Antoinette Ndayra, Raed El Samad, Kamal Achkar, Xavier Durand, Antoine Noujeim
Premature ejaculation (PE) is the most common self-reported male sexual disorder estimated to occur in approximately 5% of men in the general community. Penile hypersensitivity is thought to be an etiologic factor of lifelong PE. The role of glans penis augmentation using injectable hyaluronic acid (HA) for the treatment of PE is debatable and remains to be confirmed. The creation of a barrier at the level of the glans, by the bulking agent blocking accessibility and inhibiting the tactile stimuli to reach the dorsal nerve of the penis (branch of the pudendal nerve) receptors, is the theory behind the effectiveness of HA in the field of PE...
December 2020: Translational Andrology and Urology
#10
REVIEW
Henry Han-I Yao, Shomik Sengupta, Justin Chee
Penile cancer is a rare malignancy with a reported incidence of 0.66-1.44 per 100,000 men, and a reported mortality of 0.15-0.37 per 10,000 men. Expert clinical examination and histological diagnosis from biopsy is required to determine the extent and invasion of disease, which is paramount in planning of appropriate treatment. Management of loco-regional penile cancer can be divided into management of primary tumour and management of regional lymph nodes. This review article will focus on the management of the primary penile tumour with particular focus on penile sparing therapies...
December 2020: Translational Andrology and Urology
#11
REVIEW
Jiasian Teh, Catriona Duncan, Liang Qu, Glen Guerra, Vignesh Narasimhan, Toan Pham, Nathan Lawrentschuk
Penile cancer is an uncommon disease associated with significant psychological and physical morbidity. Penile cancer has an expectable pattern of spread in a stepwise fashion, from inguinal to pelvic lymph nodes (PLN) then distant spread. Patients with penile cancer have variable survival, with patients with a low burden of nodal metastatic disease having lasting survival with surgical management, however patients with a large amount of locoregional metastatic disease having a worse prognosis. The current management options for patients with metastatic lymph node disease in penile cancer aims to reduce the morbidity associated with radical inguinal lymph node (ILN) surgery with appropriate risk stratification to optimise oncological control of the disease...
December 2020: Translational Andrology and Urology
#12
COMMENT
Rebecca Tregunna
No abstract text is available yet for this article.
February 2021: Nature Reviews. Urology
#13
REVIEW
Ioannis Sokolakis, Nikolaos Pyrgidis, Georgios Hatzichristodoulou
Grafting for the treatment of Peyronie's disease (PD) can be performed with autologous grafts, allografts, xenografts and synthetic grafts, with all available materials presenting their own characteristics. Still, there is a current arising interest in the use of collagen fleece (TachoSil) as grafting material. We generated an extensive literature review, aiming to assess the use of TachoSil in the treatment of PD. TachoSil is currently indicated in men with PD and preserved erectile function for defect closure after partial plaque excision or incision...
January 15, 2021: International Journal of Impotence Research
#14
RANDOMIZED CONTROLLED TRIAL
Kai Zhang, Run-Qi Guo, Shan-Wen Chen, Bin Chen, Xin-Bo Xue, Shan Chen, Jian Huang, Ming Liu, Ye Tian, Li Zuo, Ming Chen, Li-Qun Zhou
PURPOSE: To perform a placebo-controlled trial to evaluate the efficacy and safety of Serenoa repens extract (SRE) for the treatment of chronic prostatitis/chronic pelvic pain syndrome (CP/CPPS). METHODS: We conducted a double-blind, randomized, placebo-controlled, multicenter, clinical phase 4 study of 221 patients with CP/CPPS across 11 centers. Participants were randomly assigned in a 2:1 ratio to receive SRE or placebo for 12 weeks. The primary efficacy endpoint was the change in total score on the National Institutes of Health-Chronic Prostatitis Symptom Index (NIH-CPSI)...
September 2021: World Journal of Urology
#15
JOURNAL ARTICLE
Ioannis Mykoniatis, Nikolaos Pyrgidis, Ioannis Sokolakis, Petros Sountoulides, Georgios Hatzichristodoulou, Apostolos Apostolidis, Dimitrios Hatzichristou
OBJECTIVES: To perform a systematic review and meta-analysis aiming to improve the level of evidence and determine the efficacy and safety of low-intensity shockwave therapy (LiST) in patients with chronic prostatitis/chronic pelvic pain syndrome (CP/CPPS). METHODS: We searched PubMed, Cochrane Library and Scopus databases from inception to November 2020 for randomised controlled trials (RCTs) exploring the role of LiST for the management of CP/CPPS. We performed a random-effects meta-analysis of RCTs comparing LiST vs sham therapy on CP/CPPS symptoms at different time-points after treatment...
August 2021: BJU International
#16
JOURNAL ARTICLE
Reza Sari Motlagh, Mohammad Abufaraj, Lin Yang, Keiichiro Mori, Benjamin Pradere, Ekaterina Laukhtina, Hadi Mostafaei, Victor M Schuettfort, Fahad Quhal, Francesco Montorsi, Mohsen Amjadi, Christian Gratzke, Shahrokh F Shariat
PURPOSE: Despite the advances in nerve sparing and minimally invasive radical prostatectomy, erectile dysfunction remains an important adverse event after radical prostatectomy. Penile rehabilitation strategies have been developed to expedite and improve erectile function recovery. However, the differential efficacy and the best penile rehabilitation strategy are unclear as yet. We conducted a systematic review and network meta-analysis to investigate and compare the efficacy of different penile rehabilitation strategies...
April 2021: Journal of Urology
#17
JOURNAL ARTICLE
Rahul Dutta, Ethan L Matz, Tyler L Overholt, William B Anderson, Nicholas A Deebel, Matthew Cowper, Ryan P Terlecki, Kyle A Scarberry
BACKGROUND: Adverse outcomes secondary to ischemic priapism (IP) are associated with time to presentation and management. AIM: To characterize patterns in presentation delay as a function of etiology and patient education regarding IP risk. METHODS: Following institutional review board approval, charts of IP patients presenting to our institution from 2010 to 2020 were reviewed. One episode of IP per patient was included for analysis. OUTCOMES: Priapism duration in patients presenting with IP...
February 2021: Journal of Sexual Medicine
#18
REVIEW
Madeleine G Manka, Lindsay A White, Faysal A Yafi, John P Mulhall, Laurence A Levine, Matthew J Ziegelmann
BACKGROUND: Peyronie's disease (PD) is a challenging clinical entity. To assist clinicians with diagnosis and management, four separate organizations have published PD guidelines over the past five years, but there remains a lack of consensus and data-driven recommendations for many aspects of diagnosis and treatment. AIM: To compare and contrast PD guidelines, highlighting key similarities and differences among the guideline panel recommendations and identify areas for further research...
February 2021: Journal of Sexual Medicine
#19
REVIEW
Paul Perito, John Mulcahy, Lexiaochuan Wen, Steven K Wilson
This workshop completes the trilogy of nuances of the various incisions used to place an inflatable penile prosthesis (IPP). Infrapubic placement was the original technique employed 50 years ago for the very first IPP surgeries. The historical perspective of the development of implantation incisions and the original Scott prosthesis highlighted in this work should be fascinating to today's younger prosthetic urologists. The developing surgeon should also find some surprising maneuvers considered important technique nuances from the highest volume infrapubic implanter in the world...
December 18, 2020: International Journal of Impotence Research
#20
JOURNAL ARTICLE
M Kanbar, F de Michele, M G Giudice, L Desmet, J Poels, C Wyns
STUDY QUESTION: What is the long-term reproductive health outcome of patients who have undergone testicular sampling for fertility preservation (FP) before and during the pubertal transition period? SUMMARY ANSWER: In long-term follow-up after testicular sampling for FP, hormonal data showed that 33% of patients had primary seminiferous tubule insufficiency (high FSH) while semen analyses showed 52% of patients having a severe reduction in total sperm counts or complete absence of ejaculated sperm...
January 1, 2021: Human Reproduction
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