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JOURNAL ARTICLE
F S Goes, M G McCusker, O J Bienvenu, D F Mackinnon, F M Mondimore, B Schweizer, J R Depaulo, J B Potash
BACKGROUND: Co-morbidity of mood and anxiety disorders is common and often associated with greater illness severity. This study investigates clinical correlates and familiality of four anxiety disorders in a large sample of bipolar disorder (BP) and major depressive disorder (MDD) pedigrees. METHOD: The sample comprised 566 BP families with 1416 affected subjects and 675 MDD families with 1726 affected subjects. Clinical characteristics and familiality of panic disorder, social phobia, specific phobia and obsessive-compulsive disorder (OCD) were examined in BP and MDD pedigrees with multivariate modeling using generalized estimating equations...
July 2012: Psychological Medicine
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MULTICENTER STUDY
Raoul Belzeaux, Nadia Correard, Laurent Boyer, Bruno Etain, Joséphine Loftus, Frank Bellivier, Thierry Bougerol, Philippe Courtet, Sébastien Gard, Jean-Pierre Kahn, Christine Passerieux, Marion Leboyer, Chantal Henry, Jean-Michel Azorin
BACKGROUND: Poor adherence to medication is frequent in Bipolar Disorder (BD). It is associated with illness severity and increases total medical cost. Several factors are associated with poor adherence but previous studies included heterogeneous cohorts of patients with and without current mood episode, with and without SUD. METHODS: We conducted a cross-sectional study, based on the Fondamental Advanced Centers of Expertise in Bipolar Disorders. 382 patients diagnosed with BD (type I, II or NOS) according to DSM-IV, with partial or complete remission and without comorbid SUD, were included...
December 2013: Journal of Affective Disorders
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COMPARATIVE STUDY
Douglas M Ruderfer, Ayman H Fanous, Stephan Ripke, Andrew McQuillin, Richard L Amdur, Pablo V Gejman, Michael C O'Donovan, Ole A Andreassen, Srdjan Djurovic, Christina M Hultman, John R Kelsoe, Stephane Jamain, Mikael Landén, Marion Leboyer, Vishwajit Nimgaonkar, John Nurnberger, Jordan W Smoller, Nick Craddock, Aiden Corvin, Patrick F Sullivan, Peter Holmans, Pamela Sklar, Kenneth S Kendler
Bipolar disorder and schizophrenia are two often severe disorders with high heritabilities. Recent studies have demonstrated a large overlap of genetic risk loci between these disorders but diagnostic and molecular distinctions still remain. Here, we perform a combined genome-wide association study (GWAS) of 19 779 bipolar disorder (BP) and schizophrenia (SCZ) cases versus 19 423 controls, in addition to a direct comparison GWAS of 7129 SCZ cases versus 9252 BP cases. In our case-control analysis, we identify five previously identified regions reaching genome-wide significance (CACNA1C, IFI44L, MHC, TRANK1 and MAD1L1) and a novel locus near PIK3C2A...
September 2014: Molecular Psychiatry
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JOURNAL ARTICLE
Chien-Hsiun Chen, Chau-Shoun Lee, Ming-Ta Michael Lee, Wen-Chen Ouyang, Chiao-Chicy Chen, Mian-Yoon Chong, Jer-Yuarn Wu, Happy Kuy-Lok Tan, Yi-Ching Lee, Liang-Jen Chuo, Nan-Ying Chiu, Hin-Yeung Tsang, Ta-Jen Chang, For-Wey Lung, Chen-Huan Chiu, Cheng-Ho Chang, Ying-Sheue Chen, Yuh-Ming Hou, Cheng-Chung Chen, Te-Jen Lai, Chun-Liang Tung, Chung-Ying Chen, Hsien-Yuan Lane, Tung-Ping Su, Jung Feng, Jin-Jia Lin, Ching-Jui Chang, Po-Ren Teng, Chia-Yih Liu, Chih-Ken Chen, I-Chao Liu, Jiahn-Jyh Chen, Ti Lu, Chun-Chieh Fan, Ching-Kuan Wu, Chang-Fang Li, Kathy Hsiao-Tsz Wang, Lawrence Shih-Hsin Wu, Hsin-Ling Peng, Chun-Ping Chang, Liang-Suei Lu, Yuan-Tsong Chen, Andrew Tai-Ann Cheng
BACKGROUND: Lithium has been a first-line choice for maintenance treatment of bipolar disorders to prevent relapse of mania and depression, but many patients do not have a response to lithium treatment. METHODS: We selected subgroups from a sample of 1761 patients of Han Chinese descent with bipolar I disorder who were recruited by the Taiwan Bipolar Consortium. We assessed their response to lithium treatment using the Alda scale and performed a genomewide association study on samples from one subgroup of 294 patients with bipolar I disorder who were receiving lithium treatment...
January 9, 2014: New England Journal of Medicine
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