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Multiple Myeloma del(17p)
Multiple Myeloma del(17p)
• Multiple myeloma with high risk features, a lit search to expand understanding.
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JOURNAL ARTICLE
Pieter Sonneveld, Hervé Avet-Loiseau, Sagar Lonial, Saad Usmani, David Siegel, Kenneth C Anderson, Wee-Joo Chng, Philippe Moreau, Michel Attal, Robert A Kyle, Jo Caers, Jens Hillengass, Jesús San Miguel, Niels W C J van de Donk, Hermann Einsele, Joan Bladé, Brian G M Durie, Hartmut Goldschmidt, María-Victoria Mateos, Antonio Palumbo, Robert Orlowski
The International Myeloma Working Group consensus updates the definition for high-risk (HR) multiple myeloma based on cytogenetics Several cytogenetic abnormalities such as t(4;14), del(17/17p), t(14;16), t(14;20), nonhyperdiploidy, and gain(1q) were identified that confer poor prognosis. The prognosis of patients showing these abnormalities may vary with the choice of therapy. Treatment strategies have shown promise for HR cytogenetic diseases, such as proteasome inhibition in combination with lenalidomide/pomalidomide, double autologous stem cell transplant plus bortezomib, or combination of immunotherapy with lenalidomide or pomalidomide...
June 16, 2016: Blood
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