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Dermatologia gral

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49 papers 25 to 100 followers
By Rosa Izu Dermatologist. Associated Professor of Dermatology. Medicine. Basque Country University
https://read.qxmd.com/read/30627618/female-pattern-hair-loss-a-clinical-pathophysiologic-and-therapeutic-review
#1
REVIEW
G Fabbrocini, M Cantelli, A Masarà, M C Annunziata, C Marasca, S Cacciapuoti
Female pattern hair loss (FPHL) is the most common form of alopecia in women. Affected women may experience psychological distress and impaired social functioning. Early diagnosis and initiation of treatment are desirable because treatments are more effective to avoid the progression of hair loss than stimulating regrowth. Typically, a diagnosis of FPHL can be confirmed by review of a patient's medical history and a physical examination alone. Testing a scalp biopsy is diagnostic but usually not required. In women with signs of hyperandrogenism, an investigation for ovarian or adrenal disorders should be performed...
December 2018: International Journal of Women's Dermatology
https://read.qxmd.com/read/30710603/the-etiology-diagnosis-and-management-of-hyperhidrosis-a-comprehensive-review-part-ii-therapeutic-options
#2
REVIEW
Shiri Nawrocki, Jisun Cha
Hyperhidrosis (HH) is a chronic disorder of excess sweat production that may have a significant adverse effect on quality of life. A variety of treatment modalities currently exist to manage HH. Initial treatment includes lifestyle and behavioral recommendations. Antiperspirants are regarded as the first-line therapy for primary focal HH and can provide significant benefit. Iontophoresis is considered to be the primary remedy for palmar and plantar HH. Botulinum toxin (BTX) injections are administered at the dermal-subcutaneous junction and serve as a safe and effective treatment option for focal HH...
January 30, 2019: Journal of the American Academy of Dermatology
https://read.qxmd.com/read/30710604/the-etiology-diagnosis-and-management-of-hyperhidrosis-a-comprehensive-review-part-i-etiology-and-clinical-work-up
#3
REVIEW
Shiri Nawrocki, Jisun Cha
Hyperhidrosis (HH) is a dermatologic disorder defined by sweat production beyond the thermoregulatory requirements. Clinically, HH is diagnosed when excess sweating creates significant emotional, physical, or social discomfort, causing negative impact on the patient's quality of life. Existing data imply that this condition may affect at least 4.8% of the US population. The etiology of HH may stem from autonomic nervous system complex dysfunction, resulting in neurogenic overactivity of otherwise normal eccrine sweat glands...
January 30, 2019: Journal of the American Academy of Dermatology
https://read.qxmd.com/read/30604525/the-efficacy-and-use-of-finasteride-in-women-a-systematic-review
#4
REVIEW
Allison C Hu, Lance W Chapman, Natasha A Mesinkovska
BACKGROUND: Physicians are beginning to use finasteride as treatment for hair loss, hirsutism, and various other dermatologic conditions in women. However, the reported efficacy and use of finasteride in the female population varies widely. The purpose of this study is therefore to better define the efficacy and use of finasteride in women and identify research gaps that require further investigation. METHODS: A systematic review of the current literature describing finasteride use in women...
January 3, 2019: International Journal of Dermatology
https://read.qxmd.com/read/30057345/jak-inhibitors-for-treatment-of-alopecia-areata
#5
REVIEW
Eddy H C Wang, Brigitte N Sallee, Christina I Tejeda, Angela M Christiano
The advancement of genetic and preclinical studies has uncovered the mechanisms involved in the pathogenesis of alopecia areata (AA). The development of targeted therapies using small molecules blocking specific pathways for the treatment of AA is underway. By repurposing Food and Drug Administration-approved small molecule JAK inhibitors as treatments for AA, it has been demonstrated that JAK inhibitors can effectively reverse hair loss in patients with moderate to severe AA. In this review, we summarize and discuss the current preclinical and clinical studies on JAK inhibitors, as well as the prospects of using JAK inhibitors for the treatment of AA...
September 2018: Journal of Investigative Dermatology
https://read.qxmd.com/read/29241773/alopecia-areata-an-appraisal-of-new-treatment-approaches-and-overview-of-current-therapies
#6
REVIEW
Lauren C Strazzulla, Eddy Hsi Chun Wang, Lorena Avila, Kristen Lo Sicco, Nooshin Brinster, Angela M Christiano, Jerry Shapiro
Many therapies are available for the treatment of alopecia areata, including topical, systemic, and injectable modalities. However, these treatment methods produce variable clinical outcomes and there are no currently available treatments that induce and sustain remission. When making management decisions, clinicians must first stratify patients into pediatric versus adult populations. Disease severity should then be determined (limited vs extensive) before deciding the final course of therapy. The second article in this continuing medical education series describes the evidence supporting new treatment methods, among them Janus kinase inhibitors...
January 2018: Journal of the American Academy of Dermatology
https://read.qxmd.com/read/30261199/a-systematic-review-of-evidence-based-treatments-for-prurigo-nodularis
#7
REVIEW
Azam A Qureshi, Laura E Abate, Gil Yosipovitch, Adam J Friedman
Prurigo nodularis is a chronic dermatologic condition involving the development of multiple cutaneous nodules in the setting of intractable pruritus. Given emerging treatment options for this difficult-to-treat condition, a current review of therapeutics is needed. A systematic review was performed for clinical studies investigating prurigo nodularis treatment published from 1990 to present including ≥5 subjects. A total of 35 articles were assigned a level of evidence according to the Oxford Center for Evidence-based Medicine...
March 2019: Journal of the American Academy of Dermatology
https://read.qxmd.com/read/30499630/how-i-investigate-eosinophilia
#8
REVIEW
Rebecca L Larsen, Natasha M Savage
Eosinophilia is typically secondary, that is, reactive, in nature and is associated with a wide variety of neoplastic and non-neoplastic disorders. Clonal eosinophilia is also seen in a wide variety of hematopoietic neoplasms, and sub-classification can be diagnostically challenging. A proper evaluation of persistent eosinophilia involves correlation of clinical history, laboratory data, cellular morphology, and ancillary testing. Knowledge of appropriate ancillary testing is necessary for a timely diagnosis...
November 30, 2018: International Journal of Laboratory Hematology
https://read.qxmd.com/read/30659454/frontal-fibrosing-alopecia-an-update-on-pathogenesis-diagnosis-and-treatment
#9
REVIEW
Matilde Iorizzo, Antonella Tosti
Frontal fibrosing alopecia (FFA), first described by Kossard in the early 1990s, is a form of primary lymphocytic cicatricial alopecia characterized by selective involvement of the frontotemporal hairline and eyebrows. Since the original description, an increasing number of cases have been reported worldwide and the clinical aspects of the disease have been better characterized. However, the pathogenesis is still unknown and several hypotheses have been made about possible triggering factors, including hormones, neurogenic inflammation, smoking, UV filters, and ingredients in leave-on facial products...
January 19, 2019: American Journal of Clinical Dermatology
https://read.qxmd.com/read/30547302/the-role-of-vitamins-and-minerals-in-hair-loss-a-review
#10
REVIEW
Hind M Almohanna, Azhar A Ahmed, John P Tsatalis, Antonella Tosti
People commonly inquire about vitamin and mineral supplementation and diet as a means to prevent or manage dermatological diseases and, in particular, hair loss. Answering these queries is frequently challenging, given the enormous and conflicting evidence that exists on this subject. There are several reasons to suspect a role for micronutrients in non-scarring alopecia. Micronutrients are major elements in the normal hair follicle cycle, playing a role in cellular turnover, a frequent occurrence in the matrix cells in the follicle bulb that are rapidly dividing...
December 13, 2018: Dermatology and Therapy
https://read.qxmd.com/read/29520159/therapeutic-management-of-classic-lichen-planopilaris-a-systematic-review
#11
REVIEW
Enzo Errichetti, Matteo Figini, Margherita Croatto, Giuseppe Stinco
Several treatment strategies have been proposed in classic lichen planopilaris (LPP), although no gold standard therapeutic approach has been recognized so far due to the variable and, sometimes, contradictory results reported in the literature, as well as due to the lack of guidelines and randomized controlled trials. In the present review, we sought to provide an updated overview on the treatment of classic LPP by analyzing the level of evidence of published studies, also proposing a possible therapeutic strategy according to the findings highlighted in this systematic review...
2018: Clinical, Cosmetic and Investigational Dermatology
https://read.qxmd.com/read/29380349/acne-and-hidradenitis-suppurativa
#12
REVIEW
A Pink, F Anzengruber, A A Navarini
Acne and hidradenitis suppurativa (HS) both centre on hair follicles. They often occur together as part of the acne tetrad, but are found in distinct localizations. Acne is primarily defined by the presence of comedones and inflammatory lesions. However, in HS the intertriginous localization and chronicity play equally important roles for the diagnosis to the inflammatory lesions. Genetics, bacteria, environmental factors and innate inflammation have all been found to play a role in acne and/or HS. Surprisingly, there is little overlap between the findings so far...
March 2018: British Journal of Dermatology
https://read.qxmd.com/read/29480033/dermatological-indications-for-the-use-of-isotretinoin-beyond-acne
#13
REVIEW
Emily Forbat, Faisal R Ali, Firas Al-Niaimi
While the use of isotretinoin has revolutionized the treatment of acne vulgaris, isotretinoin is increasingly recognized as a useful therapeutic option for many other cutaneous conditions. We review the evidence underlying the use of isotretinoin for a variety of dermatological indications including hidradenitis suppurativa, sebaceous gland pathology, rosacea, scarring alopecia, cosmetic dermatology, and non-melanoma skin cancer prophylaxis amongst other uses, and thus consider alternative uses within dermatology practice...
November 2018: Journal of Dermatological Treatment
https://read.qxmd.com/read/24698321/toll-like-receptor-2-ligands-promote-chronic-atopic-dermatitis-through-il-4-mediated-suppression-of-il-10
#14
Susanne Kaesler, Thomas Volz, Yuliya Skabytska, Martin Köberle, Ulrike Hein, Ko-Ming Chen, Emmanuella Guenova, Florian Wölbing, Martin Röcken, Tilo Biedermann
BACKGROUND: Atopic dermatitis (AD) is a T cell-mediated inflammatory skin disease, with TH2 cells initiating acute flares. This inflamed skin is immediately colonized with Staphylococcus aureus, which provides potent Toll-like receptor (TLR) 2 ligands. However, the effect of TLR2 ligands on the development of TH2-mediated AD inflammation remains unclear. OBJECTIVE: We investigated the progression of TH2 cell-mediated dermatitis after TLR2 activation. METHODS: Using models for acute AD with TH2 cells initiating cutaneous inflammation, we investigated the consequences of TLR2 activation...
July 2014: Journal of Allergy and Clinical Immunology
https://read.qxmd.com/read/29214107/diet-and-rosacea-the-role-of-dietary-change-in-the-management-of-rosacea
#15
REVIEW
Emma Weiss, Rajani Katta
Dietary change may play a role in the therapy of rosacea. Certain foods and beverages may act as "triggers" for rosacea exacerbations. These may be divided into heat-related, alcohol-related, capsaicin-related, and cinnamaldehyde-related. One potential pathogenic mechanism may be via the activation of transient receptor potential cation channels, which result in neurogenic vasodilatation. Further research is needed on the role of the gut skin connection in rosacea. Epidemiologic studies suggest that patients with rosacea have a higher prevalence of gastrointestinal disease, and one study reported improvement in rosacea following successful treatment of small intestinal bacterial overgrowth...
October 2017: Dermatology Practical & Conceptual
https://read.qxmd.com/read/29226630/microneedling-combined-with-platelet-rich-plasma-or-trichloroacetic-acid-peeling-for-management-of-acne-scarring-a-split-face-clinical-and-histologic-comparison
#16
COMPARATIVE STUDY
Moetaz El-Domyati, Hossam Abdel-Wahab, Aliaa Hossam
BACKGROUND: Minimally invasive procedures provide effective, safe, relatively long-lasting, and natural results without large damage to the skin. A combination treatment is considered an approach that includes at least 2 different and unrelated modalities. OBJECTIVES: This study aims to evaluate the use and effectiveness of some combined minimally invasive procedures for management of acne scarring. PATIENTS/METHODS: Twenty-four volunteers with postacne atrophic scars were randomly divided into 3 equal groups according to performed procedure on each side of the face (microneedling by dermaroller alone or combined with platelet-rich plasma [PRP] or trichloroacetic acid [TCA] 15% peeling) and received 6 bi-weekly sessions of treatment...
February 2018: Journal of Cosmetic Dermatology
https://read.qxmd.com/read/26735937/efficacy-and-safety-of-methotrexate-combined-with-low-to-moderate-dose-corticosteroids-for-severe-alopecia-areata
#17
Delphine Anuset, Geraldine Perceau, Philippe Bernard, Ziad Reguiai
BACKGROUND: In severe alopecia areata (AA), spontaneous recovery is unlikely, and treatment is not standardized. OBJECTIVE: To evaluate the efficacy and safety of methotrexate (MTX) used alone or combined with low- to moderate-dose oral corticosteroids (OC) for treating severe AA (totalis, universalis and severe multifocal). METHODS: Retrospective monocentric study of all consecutive patients receiving this treatment between 2006 and 2012...
2016: Dermatology: International Journal for Clinical and Investigative Dermatology
https://read.qxmd.com/read/27173969/what-is-new-in-melanoma-genetics-and-treatment
#18
REVIEW
Simone Ribero, Caterina Longo, Dan Glass, Paul Nathan, Veronique Bataille
New therapies for advanced melanoma have led to major advances, which, for the first time, showed improved survival for patients with this very challenging neoplasm. These new treatments are based on gene-targeted therapies or stimulation of immune responses. However, these treatments are not without challenges in terms of resistance and toxicity. Physicians should be aware of these side effects as prompt treatment may save lives. Melanoma genetics is also unravelling new genetic risk factors involving telomere genes as well as new gene pathways at the somatic level which may soon become therapeutic targets...
2016: Dermatology: International Journal for Clinical and Investigative Dermatology
https://read.qxmd.com/read/27711995/efficacy-and-safety-of-superficial-cryotherapy-for-alopecia-areata-a-retrospective-comprehensive-review-of-353-cases-over-22-years
#19
Myungsoo Jun, Noo Ri Lee, Won-Soo Lee
Alopecia areata (AA) affects anagen hair follicles, resulting in non-scarring hair loss. Since introduced by Huang et al., superficial cryotherapy has been accepted as a considerable primary therapeutic modality for AA. The aim of this study was to objectively clarify the therapeutic efficacy and safety of superficial hypothermic cryotherapy for treatment of AA. Medical records of 353 patients from 1993 to 2014 were retrospectively analyzed. According to the response to the superficial cryotherapy, patients were categorized into four groups: "marked", "partial", "poor" and "no recovery"...
April 2017: Journal of Dermatology
https://read.qxmd.com/read/27745649/general-management-strategy-for-epidermal-growth-factor-receptor-inhibitor-associated-papulopustular-eruption
#20
Benjamin Farahnik, Bernice Kwong, Jenny Murase
No abstract text is available yet for this article.
November 2016: Journal of the American Academy of Dermatology
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