Susanne Kaesler, Thomas Volz, Yuliya Skabytska, Martin Köberle, Ulrike Hein, Ko-Ming Chen, Emmanuella Guenova, Florian Wölbing, Martin Röcken, Tilo Biedermann
BACKGROUND: Atopic dermatitis (AD) is a T cell-mediated inflammatory skin disease, with TH2 cells initiating acute flares. This inflamed skin is immediately colonized with Staphylococcus aureus, which provides potent Toll-like receptor (TLR) 2 ligands. However, the effect of TLR2 ligands on the development of TH2-mediated AD inflammation remains unclear. OBJECTIVE: We investigated the progression of TH2 cell-mediated dermatitis after TLR2 activation. METHODS: Using models for acute AD with TH2 cells initiating cutaneous inflammation, we investigated the consequences of TLR2 activation...
July 2014: Journal of Allergy and Clinical Immunology