Mamta Puraswani, Priyanka Khandelwal, Himanshi Saini, Savita Saini, Bahadur Singh Gurjar, Aditi Sinha, Rajashri Pramod Shende, Tushar Kanti Maiti, Abhishek Kumar Singh, Uma Kanga, Uma Ali, Indira Agarwal, Kanav Anand, Narayan Prasad, Padmaraj Rajendran, Rajiv Sinha, Anil Vasudevan, Anita Saxena, Sanjay Agarwal, Pankaj Hari, Arvind Sahu, Satyajit Rath, Arvind Bagga
Background: Atypical hemolytic uremic syndrome (aHUS), an important cause of acute kidney injury (AKI), is characterized by dysregulation of the alternative complement pathway. Autoantibodies to factor H (FH), a chief regulator of this pathway, account for a distinct subgroup. While high anti-FH titers predict relapse, they do not correlate well with disease activity and their functional characterization is required. Methods: Of 781 patients <18-year-old of aHUS in the nationwide database from 2007 to 2018, 436 (55...
2019: Frontiers in Immunology