Alexandre Loupy, Carmen Lefaucheur, Dewi Vernerey, Jessica Chang, Luis G Hidalgo, Thibaut Beuscart, Jerome Verine, Olivier Aubert, Sébastien Dubleumortier, Jean-Paul Duong van Huyen, Xavier Jouven, Denis Glotz, Christophe Legendre, Philip F Halloran
Antibody-mediated rejection (ABMR) is the leading cause of kidney allograft loss. We investigated whether the addition of gene expression measurements to conventional methods could serve as a molecular microscope to identify kidneys with ABMR that are at high risk for failure. We studied 939 consecutive kidney recipients at Necker Hospital (2004-2010; principal cohort) and 321 kidney recipients at Saint Louis Hospital (2006-2010; validation cohort) and assessed patients with ABMR in the first 1 year post-transplant...
October 2014: Journal of the American Society of Nephrology: JASN