François Blachier, Martin Beaumont, Mireille Andriamihaja, Anne-Marie Davila, Annaïg Lan, Marta Grauso, Lucie Armand, Robert Benamouzig, Daniel Tomé
Evidence, mostly from experimental models, has accumulated, indicating that modifications of bacterial metabolite concentrations in the large intestine luminal content, notably after changes in the dietary composition, may have important beneficial or deleterious consequences for the colonic epithelial cell metabolism and physiology in terms of mitochondrial energy metabolism, reactive oxygen species production, gene expression, DNA integrity, proliferation, and viability. Recent data suggest that for some bacterial metabolites, like hydrogen sulfide and butyrate, the extent of their oxidation in colonocytes affects their capacity to modulate gene expression in these cells...
March 2017: American Journal of Pathology