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Neurotransmitters and related Papers: medical and naturopahic

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36 papers 1000+ followers
By Christopher Cook, BA,CADC, SAP Addiction professional. LPC, CADC, CRNP- student, Interventionist, project manager, owner, Director, eval/refer for SUDs/Eating D/o's
https://read.qxmd.com/read/25843781/gamma-hydroxybutyrate-ghb-gamma-butyrolactone-gbl-and-1-4-butanediol-1-4-bd-bdo-a-literature-review-with-a-focus-on-uk-fatalities-related-to-non-medical-use
#1
REVIEW
John M Corkery, Barbara Loi, Hugh Claridge, Christine Goodair, Ornella Corazza, Simon Elliott, Fabrizio Schifano
Misuse of gamma hydroxybutrate (GHB) and gamma butyrolactone (GBL) has increased greatly since the early 1990s, being implicated in a rising number of deaths. This paper reviews knowledge on GHB and derivatives, and explores the largest series of deaths associated with their non-medical use. Descriptive analyses of cases associated with GHB/GBL and 1,4-butanediol (1,4-BD) use extracted from the UK's National Programme on Substance Abuse Deaths database. From 1995 to September 2013, 159 GHB/GBL-associated fatalities were reported...
June 2015: Neuroscience and Biobehavioral Reviews
https://read.qxmd.com/read/29383983/the-role-of-the-gut-microbiota-in-schizophrenia-current-and-future-perspectives
#2
REVIEW
Daniela Rodrigues-Amorim, Tania Rivera-Baltanás, Benito Regueiro, Carlos Spuch, María Elena de Las Heras, Raul Vázquez-Noguerol Méndez, Maria Nieto-Araujo, Carolina Barreiro-Villar, Jose Manuel Olivares, Roberto Carlos Agís-Balboa
OBJECTIVES: Schizophrenia is a poorly understood chronic disease. Its pathophysiology is complex, dynamic, and linked to epigenetic mechanisms and microbiota involvement. Nowadays, correlating schizophrenia with the environment makes sense owing to its multidimensional implications: temporal and spatial variability. Microbiota involvement and epigenetic mechanisms are factors that are currently being considered to better understand another dimension of schizophrenia. METHODS: This review summarises and discusses currently available information, focussing on the microbiota, epigenetic mechanisms, technological approaches aimed at performing exhaustive analyses of the microbiota, and psychotherapies, to establish future perspectives...
December 2018: World Journal of Biological Psychiatry
https://read.qxmd.com/read/30204559/anxiolytics-targeting-gaba-a-receptors-insights-on-etifoxine
#3
REVIEW
Pierrick Poisbeau, Geraldine Gazzo, Laurent Calvel
OBJECTIVES: Anxiety and adjustment disorders are among the most prevalent mental health conditions. This review focuses on γ-aminobutyric acid receptor type A (GABAA R)-mediated anxiolysis, describing the action of both endogenous and exogenous modulators of GABAA R. Future directions and innovative strategies to alleviate anxiety symptoms are discussed, with a particular emphasis on etifoxine. METHODS: We used available data from the recent literature to update the mode of action of anxiolytics...
2018: World Journal of Biological Psychiatry
https://read.qxmd.com/read/26554370/a-meta-analysis-of-placebo-controlled-trials-of-omega-3-fatty-acid-augmentation-in-schizophrenia-possible-stage-specific-effects
#4
Alexander T Chen, John T Chibnall, Henry A Nasrallah
BACKGROUND: Omega-3 fatty acids have shown promise as an adjunctive treatment for schizophrenia. However, efficacy across studies has been inconsistent. We conducted a meta-analysis of published controlled studies with the goal of detecting different efficacy profiles at various stages of schizophrenia. METHODS: An online search was conducted for randomized, double-blind, placebo-controlled clinical trials, and a meta-analysis was conducted. RESULTS: Ten studies met the criteria for inclusion...
November 2015: Annals of Clinical Psychiatry: Official Journal of the American Academy of Clinical Psychiatrists
https://read.qxmd.com/read/27490835/placebo-controlled-augmentation-trials-of-the-antioxidant-nac-in-schizophrenia-a-review
#5
REVIEW
Alexander T Chen, John T Chibnall, Henry A Nasrallah
BACKGROUND: Several studies have reported that schizophrenia is associated with mitochondrial abnormalities, glutathione deficit, and increased brain oxidative stress (free radicals). N-acetylcysteine (NAC) is a strong antioxidant with potential therapeutic benefit in schizophrenia, according to some reports. We conducted a review of the published controlled studies, with the goal of determining the efficacy profile of NAC as an adjunctive treatment for schizophrenia. METHODS: An online search was conducted for all placebo-controlled, double-blind, randomized clinical trials of NAC in schizophrenia, and a review was conducted...
August 2016: Annals of Clinical Psychiatry: Official Journal of the American Academy of Clinical Psychiatrists
https://read.qxmd.com/read/30624551/association-of-combined-naltrexone-and-ketamine-with-depressive-symptoms-in-a-case-series-of-patients-with-depression-and-alcohol-use-disorder
#6
Gihyun Yoon, Ismene L Petrakis, John H Krystal
No abstract text is available yet for this article.
March 1, 2019: JAMA Psychiatry
https://read.qxmd.com/read/30711326/dopamine-and-cognitive-control-in-prefrontal-cortex
#7
REVIEW
Torben Ott, Andreas Nieder
Cognitive control, the ability to orchestrate behavior in accord with our goals, depends on the prefrontal cortex. These cognitive functions are heavily influenced by the neuromodulator dopamine. We review here recent insights exploring the influence of dopamine on neuronal response properties in prefrontal cortex (PFC) during ongoing behaviors in primates. This review suggests three major computational roles of dopamine in cognitive control: (i) gating sensory input, (ii) maintaining and manipulating working memory contents, and (iii) relaying motor commands...
March 2019: Trends in Cognitive Sciences
https://read.qxmd.com/read/30823984/lateral-habenular-burst-firing-as-a-target-of-the-rapid-antidepressant-effects-of-ketamine
#8
REVIEW
Yihui Cui, Shaohua Hu, Hailan Hu
The revolutionary discovery of the rapid antidepressant ketamine has been a milestone in psychiatry field in the last half century. Unlike conventional antidepressants that often take weeks to months to show efficacy, ketamine causes rapid antidepressant effects, emerging as early as within 1h after administration. However, how ketamine improves mood symptoms so quickly has remained elusive. Here, we first introduce the historical background of ketamine as a rapid antidepressant. We then discuss current hypotheses underlying ketamine's rapid antidepressant effects, with a focus on our latest discovery that ketamine silences NMDAR-dependent burst firing in the 'anti-reward center', the lateral habenula...
March 2019: Trends in Neurosciences
https://read.qxmd.com/read/24418446/cannabinoid-hyperemesis-acute-renal-failure-a-common-sequela-of-cannabinoid-hyperemesis-syndrome
#9
REVIEW
Joseph Habboushe, Jennifer Sedor
We report the case of a 25-year-old man with an 8-year history of daily marijuana use diagnosed with acute renal failure secondary to cannabinoid hyperemesis syndrome. The patient presented with “constant” vomiting for over a day. His symptoms were completely relieved with compulsive hot showering and partially relieved by hot baths, by high ambient room temperature, and transiently after smoking marijuana. The patient was found to have a creatinine of 3.21 and admitted for acute renal failure secondary to cannabinoid hyperemesis syndrome...
June 2014: American Journal of Emergency Medicine
https://read.qxmd.com/read/29122973/capsaicin-cream-for-treatment-of-cannabinoid-hyperemesis-syndrome-in-adolescents-a-case-series
#10
Jessica Graham, Michael Barberio, George Sam Wang
Cannabinoid hyperemesis syndrome (CHS) is an underrecognized diagnosis among adolescents. In the adult literature, it is characterized as nausea, vomiting, and abdominal pain in patients with chronic marijuana use. CHS is often refractory to the standard treatment of nausea and vomiting. Unconventional antiemetics, such as haloperidol, have been successful in alleviating symptoms; however, even 1 dose of haloperidol can lead to grave adverse effects, such as dystonia, extrapyramidal reactions, and neuroleptic malignant syndrome...
December 2017: Pediatrics
https://read.qxmd.com/read/30773866/-brain-regions-responding-to-acupuncture-stimulation-of-zusanli-st36-in-healthy-subjects-analyzed-on-the-basis-of-spontaneous-brain-activity
#11
An-Feng Xiang, Hui Liu, Sheng Liu, Xue-Yong Shen
OBJECTIVE: To determine the attributes of responses of the higher nerve center to acupuncture stimulation of Zusanli (ST36) on the basis of spontaneous brain activity, so as to explore the synchronization level of different brain rejoins after acupuncture. METHODS: All studies using fMRI to investigate the effect of acupuncture stimulation of ST36 and/or other acupoints on the human brain (at least 10 healthy subjects or patients in one group) published in journals from January of 1995 to January of 2018 were searched from databases of CNKI and PubMed by using keywords of acupuncture, electroacupuncture, and resting-state functional magnetic resonance images (rs-fMRI) or regional homogeneity (ReHo)...
January 25, 2019: Zhen Ci Yan Jiu, Acupuncture Research
https://read.qxmd.com/read/29576387/functional-divergence-of-delta-and-mu-opioid-receptor-organization-in-cns-pain-circuits
#12
Dong Wang, Vivianne L Tawfik, Gregory Corder, Sarah A Low, Amaury François, Allan I Basbaum, Grégory Scherrer
Cellular interactions between delta and mu opioid receptors (DORs and MORs), including heteromerization, are thought to regulate opioid analgesia. However, the identity of the nociceptive neurons in which such interactions could occur in vivo remains elusive. Here we show that DOR-MOR co-expression is limited to small populations of excitatory interneurons and projection neurons in the spinal cord dorsal horn and unexpectedly predominates in ventral horn motor circuits. Similarly, DOR-MOR co-expression is rare in parabrachial, amygdalar, and cortical brain regions processing nociceptive information...
April 4, 2018: Neuron
https://read.qxmd.com/read/27546878/the-neurocircuitry-involved-in-oxytocin-modulation-of-methamphetamine-addiction
#13
REVIEW
Sarah J Baracz, Jennifer L Cornish
The role of oxytocin in attenuating the abuse of licit and illicit drugs, including the psychostimulant methamphetamine, has been examined with increased ferocity in recent years. This is largely driven by the potential application of oxytocin as a pharmacotherapy. However, the neural mechanisms by which oxytocin modulates methamphetamine abuse are not well understood. Recent research identified an important role for the accumbens core and subthalamic nucleus in this process, which likely involves an interaction with dopamine, glutamate, GABA, and vasopressin...
October 2016: Frontiers in Neuroendocrinology
https://read.qxmd.com/read/26346640/intranasal-oxytocin-affects-amygdala-functional-connectivity-after-trauma-script-driven-imagery-in-distressed-recently-trauma-exposed-individuals
#14
RANDOMIZED CONTROLLED TRIAL
Jessie L Frijling, Mirjam van Zuiden, Saskia B J Koch, Laura Nawijn, Dick J Veltman, Miranda Olff
Approximately 10% of trauma-exposed individuals go on to develop post-traumatic stress disorder (PTSD). Neural emotion regulation may be etiologically involved in PTSD development. Oxytocin administration early post-trauma may be a promising avenue for PTSD prevention, as intranasal oxytocin has previously been found to affect emotion regulation networks in healthy individuals and psychiatric patients. In a randomized double-blind placebo-controlled between-subjects functional magnetic resonance (fMRI) study, we assessed the effects of a single intranasal oxytocin administration (40 IU) on seed-based amygdala resting-state FC with emotion regulation areas (ventromedial prefrontal cortex (vmPFC), ventrolateral prefrontal cortex (vlPFC)), and salience processing areas (insula, dorsal anterior cingulate cortex (dACC)) in 37 individuals within 11 days post trauma...
April 2016: Neuropsychopharmacology: Official Publication of the American College of Neuropsychopharmacology
https://read.qxmd.com/read/25454355/a-general-approach-avoidance-hypothesis-of-oxytocin-accounting-for-social-and-non-social-effects-of-oxytocin
#15
REVIEW
Osnat Harari-Dahan, Amit Bernstein
BACKGROUND: We critically reexamine extant theory and empirical study of Oxytocin. We question whether OT is, in fact, a "social neuropeptide" as argued in dominant theories of OT. METHOD: We critically review human and animal research on the social and non-social effects of Oxytocin, including behavioral, psychophysiological, neurobiological, and neuroimaging studies. RESULTS: We find that extant (social) theories of Oxytocin do not account for well-documented non-social effects of Oxytocin...
November 2014: Neuroscience and Biobehavioral Reviews
https://read.qxmd.com/read/25070538/oxytocin-s-neurochemical-effects-in-the-medial-prefrontal-cortex-underlie-recovery-of-task-specific-brain-activity-in-autism-a-randomized-controlled-trial
#16
RANDOMIZED CONTROLLED TRIAL
Y Aoki, T Watanabe, O Abe, H Kuwabara, N Yahata, Y Takano, N Iwashiro, T Natsubori, H Takao, Y Kawakubo, K Kasai, H Yamasue
The neuropeptide oxytocin may be an effective therapeutic strategy for the currently untreatable social and communication deficits associated with autism. Our recent paper reported that oxytocin mitigated autistic behavioral deficits through the restoration of activity in the ventromedial prefrontal cortex (vmPFC), as demonstrated with functional magnetic resonance imaging (fMRI) during a socio-communication task. However, it is unknown whether oxytocin exhibited effects at the neuronal level, which was outside of the specific task examined...
April 2015: Molecular Psychiatry
https://read.qxmd.com/read/30578416/deep-learning-for-genomics
#17
EDITORIAL
(no author information available yet)
Application of deep learning to genomic datasets is an exciting area that is rapidly developing and is primed to revolutionize genome analysis. We embrace the potential that deep learning holds for understanding genome biology, and we encourage further advances in this area, extending to all aspects of genomics research.
January 2019: Nature Genetics
https://read.qxmd.com/read/30476795/gene-expression-signature-in-brain-regions-exposed-to-long-term-psychosocial-stress-following-acute-challenge-with-cannabinoid-drugs
#18
J Tomas-Roig, U Havemann-Reinecke
Repeated exposure to life stressors can overwhelm the body's capacity to restore homeostasis and result in severe negative consequences. Cannabinoid CB1 receptors are highly expressed in the Central Nervous System (CNS) and regulate both glucocorticoid signalling and neurotransmitter release. In rodents, WIN55212.2 is a full agonist at the cannabinoid receptor type-1, while Rimonabant is a potent and selective cannabinoid inverse agonist at this receptor. This study aims to investigate the effect of long-term psychosocial stress following acute challenge with cannabinoid drugs on gene expression in distinct brain regions; this is done by employing digital multiplexed gene expression analysis...
April 2019: Psychoneuroendocrinology
https://read.qxmd.com/read/30639103/crystal-structure-of-the-human-cannabinoid-receptor-cb2
#19
Xiaoting Li, Tian Hua, Kiran Vemuri, Jo-Hao Ho, Yiran Wu, Lijie Wu, Petr Popov, Othman Benchama, Nikolai Zvonok, K'ara Locke, Lu Qu, Gye Won Han, Malliga R Iyer, Resat Cinar, Nathan J Coffey, Jingjing Wang, Meng Wu, Vsevolod Katritch, Suwen Zhao, George Kunos, Laura M Bohn, Alexandros Makriyannis, Raymond C Stevens, Zhi-Jie Liu
The cannabinoid receptor CB2 is predominately expressed in the immune system, and selective modulation of CB2 without the psychoactivity of CB1 has therapeutic potential in inflammatory, fibrotic, and neurodegenerative diseases. Here, we report the crystal structure of human CB2 in complex with a rationally designed antagonist, AM10257, at 2.8 Å resolution. The CB2-AM10257 structure reveals a distinctly different binding pose compared with CB1. However, the extracellular portion of the antagonist-bound CB2 shares a high degree of conformational similarity with the agonist-bound CB1, which led to the discovery of AM10257's unexpected opposing functional profile of CB2 antagonism versus CB1 agonism...
December 21, 2018: Cell
https://read.qxmd.com/read/30568202/brain-circuits-of-compulsive-drug-addiction-identified
#20
COMMENT
Patricia Janak
No abstract text is available yet for this article.
December 2018: Nature
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