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JOURNAL ARTICLE
Tatiana M Prowell, Julia A Beaver, Richard Pazdur
In the KATHERINE trial, whose results are reported by von Minckwitz et al. in this issue of the Journal (pages 617–28), 1486 patients with human epidermal growth factor receptor 2 (HER2)–positive early-stage breast cancer who had residual invasive cancer after preoperative chemotherapy plus..
February 14, 2019: New England Journal of Medicine
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JOURNAL ARTICLE
George Q Daley, Robin Lovell-Badge, Julie Steffann
The recent announcement of the birth of twins whose genomes were edited during in vitro fertilization (IVF) has engendered broad condemnation for the premature clinical deployment of a fledgling but powerful biotechnology. The Chinese scientist He Jiankui may claim priority for the first use of..
January 16, 2019: New England Journal of Medicine
#23
JOURNAL ARTICLE
Lisa Rosenbaum
On the day after Thanksgiving 2018, Jennifer Doudna, a biochemist at the University of California, Berkeley, whose research on bacterial immune systems led to the gene-editing technique known as CRISPR (for Clustered Regularly Interspaced Short Palindromic Repeats), received a startling email from..
March 7, 2019: New England Journal of Medicine
#24
JOURNAL ARTICLE
Julia L Marcus, Kenneth A Katz, Douglas S Krakower, Sarah K Calabrese
Imagine a daily pill that prevents an unwanted consequence of sexual intercourse. Does it give users a "license for promiscuity"? Will its widespread availability lead to "sexual anarchy"? These questions were posed more than a half-century ago about oral contraceptive pills, which enabled..
February 7, 2019: New England Journal of Medicine
#25
LETTER
Muthiah Vaduganathan, Sara R Machado, Ersilia M DeFilippis, Navkaranbir Bajaj, Josef Stehlik, Elias Mossialos, John A Jarcho, Mandeep R Mehra
To the Editor: The drug-overdose epidemic has led to an increase in the number of organ donors dying from drug intoxication; this pattern is confined to the United States and has not been observed in Europe. Geographic disparity in the rates of death from drug intoxication in the United States led..
February 7, 2019: New England Journal of Medicine
#26
JOURNAL ARTICLE
Bruce E Landon
Even as the U.S. health care system increasingly adopts alternative payment models such as accountable care organizations, the traditional fee-for-service system continues to be the most commonly used method of physician payment. Moreover, although alternative payment models often involve budgets..
February 7, 2019: New England Journal of Medicine
#27
JOURNAL ARTICLE
Genevieve P Kanter, Mark V Pauly
Suppose you are a Medicare-insured patient with coronary artery disease. You will visit, on average, 10 physicians at six practice sites in a given year. Such fragmentation of care has spurred efforts by health care systems and payers to coordinate the delivery of care by multiple providers in a..
January 31, 2019: New England Journal of Medicine
#28
JOURNAL ARTICLE
Lynn A Flint, Daniel J David, Alexander K Smith
Ms. P. was an 87-year-old woman with moderate dementia who lived alone in an apartment before being admitted to the hospital with pneumonia. During her hospitalization, she became deconditioned and could no longer walk without assistance. Friends and family were unable to provide the amount of help..
January 31, 2019: New England Journal of Medicine
#29
LETTER
Tista S Ghosh, Rickey Tolliver, Alison Reidmohr, Michelle Lynch
To the Editor: In 2017, Colorado had the dubious distinction of leading the nation in the use of nicotine-containing vapor products (electronic cigarettes), or vaping, among young people under the age of 18 years. According to the national Youth Risk Behavior Survey (YRBS) for that year, one in..
February 14, 2019: New England Journal of Medicine
#30
JOURNAL ARTICLE
Cynthia H Chuang, Carol S Weisman
On November 15, 2018, the Trump administration took an aggressive stand against reproductive rights by publishing two final rules that would broadly allow employers to deny contraceptive coverage to their employees on the basis of religious or moral objections. The rules, which aimed to erode the..
March 14, 2019: New England Journal of Medicine
#31
JOURNAL ARTICLE
Richard P Wenzel
The increasingly sharp focus in the United States on the business contours of medicine and the related use of a productivity lens for basing salaries on Medicare relative value units (RVUs) have left many health care providers disheartened. Young doctors, especially, fill the unforgiving minute..
January 24, 2019: New England Journal of Medicine
#32
JOURNAL ARTICLE
Ameya Kulkarni
He was younger than I was when we diagnosed the disease that would kill him. Even as the words came out — "There is nothing more we can do" — I felt drained by the weight of his life cut short and the guilt of my own good health. I sought refuge in the residents’ lounge. Amid the cacophony of..
January 24, 2019: New England Journal of Medicine
#33
JOURNAL ARTICLE
Peter A Ubel, Meredith B Rosenthal
In late 2014 and early 2015 in California, 159 people contracted measles. The outbreak was due in large part to the state’s low measles vaccination rate, raising the question of how best to change behaviors that have public health consequences. In recent years, health care leaders have increasingly..
January 24, 2019: New England Journal of Medicine
#34
JOURNAL ARTICLE
Kevin A Schulman, Barak D Richman
Digital technologies have transformed the U.S. and global economies, offering tremendous benefits to consumers and financial success to investors. Health sector leaders, inspired by this enormous transformation, have embraced digital technology as key to health care reform efforts, promoting..
March 7, 2019: New England Journal of Medicine
#35
REVIEW
Andy Haines, Kristie Ebi
Climate change is already adversely affecting human health and health systems, and projected climate change is expected to alter the geographic range and burden of a variety of climate-sensitive health outcomes and to affect the functioning of public health and health care systems. If no additional..
January 17, 2019: New England Journal of Medicine
#36
JOURNAL ARTICLE
George Karandinos, Philippe Bourgois
Mr. M. an uninsured, 44-year-old Puerto Rican man with chronic back pain, diabetes, hypertension, asthma, and a history of incarceration presented to a free clinic with acute exacerbation of back pain triggered by carrying heavy loads of trash at work. A premedical student acting as his health care..
January 17, 2019: New England Journal of Medicine
#37
JOURNAL ARTICLE
Caren G Solomon, Regina C LaRocque
As the Camp wildfire spread rapidly in California in early November 2018, the University of California, Davis, Burn Center received a call that nearby Feather City Hospital was on fire and patients were being urgently transferred. That, recalls David Greenhalgh, professor and chief of the Burn..
January 17, 2019: New England Journal of Medicine
#38
JOURNAL ARTICLE
Brendan M Reilly
It’s an express care clinic, next door to a smoke shop in the mall. The website advertises on-site radiology services, and that’s all we want, an x-ray. In response to our request, the receptionist arches an eyebrow; she hasn’t heard that one before. "You’ll need to see a provider first," she says...
January 17, 2019: New England Journal of Medicine
#39
JOURNAL ARTICLE
Mark A Hall, Loren Adler, Paul B Ginsburg, Erin Trish
The emergence of health plans with narrower provider networks has been hailed by some observers as a positive development arising in part from more competitive market conditions brought about by the Affordable Care Act (ACA). As long envisioned by health policy analysts, competition among insurers..
February 14, 2019: New England Journal of Medicine
#40
JOURNAL ARTICLE
R Alta Charo
Type "rogue scientist" into Google, and the first page of results contains nothing but articles about He Jiankui, the Chinese scientist who stunned the world in November 2018 by announcing the birth of twin girls whose genomes were edited during in vitro fertilization (IVF). Along with the..
March 7, 2019: New England Journal of Medicine
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