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Breast cancer

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7 papers 25 to 100 followers
By Fernando Godayol Cirujano General, Mastologo, Cirujano Bariatra
J de Boniface, J Frisell, L Bergkvist, Y Andersson
BACKGROUND: The prognostic equivalence between mastectomy and breast-conserving surgery (BCS) followed by radiotherapy was shown in pivotal trials conducted decades ago. Since then, detection and treatment of breast cancer have improved substantially and recent retrospective analyses point towards a survival benefit for less extensive breast surgery. Evidence for the association of such survival data with locoregional recurrence rates is largely lacking. METHODS: The Swedish Multicentre Cohort Study prospectively included clinically node-negative patients with breast cancer who had planned sentinel node biopsy between 2000 and 2004...
November 2018: British Journal of Surgery
Danielle M Bello, Christy Russell, Debbie McCullough, Marni Tierno, Monica Morrow
BACKGROUND/OBJECTIVE: The 21-gene Oncotype DX® Breast Recurrence Score® (RS) assay has been prospectively validated as prognostic and predictive in node-negative, estrogen receptor-positive (ER+)/HER2- breast cancer patients. Less is known about its prognostic role in node-positive breast cancer. We compared RS results among patients with lymph node-negative (N0), micrometastatic (N1mi), and macrometastatic (N+) breast cancer to determine if nodal metastases are associated with more aggressive biology, as determined by RS...
October 2018: Annals of Surgical Oncology
Hang Zhang, Xiufang Sui, Suzhi Zhou, Lei Hu, Xian Huang
OBJECTIVES: To explore the association between the ultrasound (US) characteristics of breast tumors with axillary lymph node metastasis (ALNM) and Ki-67 expression in patients with breast cancer. METHODS: In total, 527 consecutive patients with breast cancer who had undergone US examinations and curative surgery with axillary lymph node evaluations were included. The size, shape, aspect ratio, margin, internal echo, internal calcification, posterior echo attenuation, lymphatic hilar structure, cortical thickness, and blood flow of the axillary lymph nodes or primary breast lesions were observed with conventional US...
November 27, 2018: Journal of Ultrasound in Medicine: Official Journal of the American Institute of Ultrasound in Medicine
Ann H Partridge, Olivia Pagani, Omalkhair Abulkhair, Stefan Aebi, Frédéric Amant, Hatem A Azim, Alberto Costa, Suzette Delaloge, Gloria Freilich, Oreste Davide Gentilini, Nadia Harbeck, Catherine M Kelly, Sibylle Loibl, Dror Meirow, Fedro Peccatori, Bella Kaufmann, Fatima Cardoso
The 1st International Consensus Conference for Breast Cancer in Young Women (BCY1) took place in November 2012, in Dublin, Ireland organized by the European School of Oncology (ESO). Consensus recommendations for management of breast cancer in young women were developed and areas of research priorities were identified. This manuscript summarizes these international consensus recommendations, which are also endorsed by the European Society of Breast Specialists (EUSOMA).
June 2014: Breast: Official Journal of the European Society of Mastology
Roshni Rao, David Euhus, Helen G Mayo, Charles Balch
IMPORTANCE: Recent data from clinical trials have challenged traditional thinking about axillary surgery in patients with breast cancer. OBJECTIVES: To summarize evidence regarding the role of axillary interventions (surgical and nonsurgical) in breast cancer treatment and to review the association of these axillary interventions with recurrence of axillary node metastases, mortality, and morbidity outcomes in patients with breast cancer. EVIDENCE REVIEW: Ovid MEDLINE (1946-July 2013), Cochrane Database of Systematic Reviews (2005-July 2013), Cochrane Database of Abstracts of Reviews of Effects (1994-July 2013), and Cochrane Central Register of Controlled Trials (1989-July 2013) were searched for publications on axillary interventions in breast cancer...
October 2, 2013: JAMA: the Journal of the American Medical Association
Tiffanie Jones, Hanmanth Neboori, H Wu, Qifeng Yang, Bruce G Haffty, Susan Evans, Susan Higgins, Meena S Moran
BACKGROUND: Breast cancer subtypes (BCS) determined from immunohistochemical staining have been correlated with molecular subtypes and associated with prognosis and outcomes, but there are limited data correlating these BCS and axillary node involvement. This study was conducted to assess whether BCS predicted for nodal metastasis or was associated with other clinicopathologic features at presentation. METHODS: Patients with stage I/II disease who underwent breast-conserving surgery and axillary surgical assessment with available tissue blocks underwent a institutional pathological review and construction of a tissue microarray...
September 2013: Annals of Surgical Oncology
Jeffrey D Crawford, Mindy Ansteth, Jim Barnett, Margie Glissmeyer, Nathalie G Johnson
BACKGROUND: The current practice of completion axillary lymph node dissection (ALND) for patients with a positive sentinel lymph node (SLN) is being questioned. This led us to examine the outcomes of patients with positive SLNs undergoing mastectomy who underwent ALND compared with those who did not. METHODS: A retrospective review of cancer registry data identified 561 women with stages 1 to 3 breast cancer with positive SLNs who underwent mastectomy between 2000 and 2010...
May 2013: American Journal of Surgery
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