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18 papers 0 to 25 followers
Henrique L Staniak, Márcio Sommer Bittencourt, Itamar de Souza Santos, Rodolfo Sharovsky, Cid Sabbag, Alessandra C Goulart, Paulo A Lotufo, Isabela M Benseñor
BACKGROUND: Emerging data suggests that chronic inflammatory disease, such as psoriasis, may be associated to coronary artery disease (CAD). OBJECTIVE: Analyze the association between psoriasis and subclinical atherosclerosis using coronary calcium score (CAC). METHODS: We investigated 221 participants with psoriasis and 718 age- and sex-matched controls without prior known CAD. All participants completed a questionnaire and underwent laboratory tests and a CAC exam...
December 2014: Atherosclerosis
Michael J Blaha, Miguel Cainzos-Achirica, Philip Greenland, John W McEvoy, Ron Blankstein, Matthew J Budoff, Zeina Dardari, Christopher T Sibley, Gregory L Burke, Richard A Kronmal, Moyses Szklo, Roger S Blumenthal, Khurram Nasir
BACKGROUND: Limited attention has been paid to negative cardiovascular disease (CVD) risk markers despite their potential to improve medical decision making. We compared 13 negative risk markers using diagnostic likelihood ratios (DLRs), which model the change in risk for an individual after the result of an additional test. METHODS AND RESULTS: We examined 6814 participants from the Multi-Ethnic Study of Atherosclerosis. Coronary artery calcium score of 0, carotid intima-media thickness <25th percentile, absence of carotid plaque, brachial flow-mediated dilation >5% change, ankle-brachial index >0...
March 1, 2016: Circulation
Baoge Qu, Tao Qu
Atherosclerosis causes significant morbidity and mortality. Carotid intima-media thickness (CIMT) predicts future cardiovascular and ischaemic stroke incidence. CIMT, a measure of atherosclerotic disease, can be reliably determined in vivo by carotid ultrasound. In this review, we determined that CIMT is associated with traditional cardiovascular risk factors such as age, sex, race, smoking, alcohol consumption, habitual endurance exercise, blood pressure, dyslipidemia, dietary patterns, risk-lowering drug therapy, glycemia, hyperuricemia, obesity-related anthropometric parameters, obesity and obesity-related diseases...
December 15, 2015: Cardiovascular Ultrasound
Benjamin Z Galper, Y Claire Wang, Andrew J Einstein
BACKGROUND: Several approaches have been proposed for risk-stratification and primary prevention of coronary heart disease (CHD), but their comparative and cost-effectiveness is unknown. METHODS: We constructed a state-transition microsimulation model to compare multiple approaches to the primary prevention of CHD in a simulated cohort of men aged 45-75 and women 55-75. Risk-stratification strategies included the 2013 American College of Cardiology/American Heart Association (ACC/AHA) guidelines on the treatment of blood cholesterol, the Adult Treatment Panel (ATP) III guidelines, and approaches based on coronary artery calcium (CAC) scoring and C-reactive protein (CRP)...
2015: PloS One
Raimund Erbel, Nils Lehmann, Sofia Churzidse, Michael Rauwolf, Amir A Mahabadi, Stefan Möhlenkamp, Susanne Moebus, Marcus Bauer, Hagen Kälsch, Thomas Budde, Michael Montag, Axel Schmermund, Andreas Stang, Dagmar Führer-Sakel, Christian Weimar, Ulla Roggenbuck, Nico Dragano, Karl-Heinz Jöckel
AIM: Coronary artery calcification (CAC), as a sign of atherosclerosis, can be detected and progression quantified using computed tomography (CT). We develop a tool for predicting CAC progression. METHODS AND RESULTS: In 3481 participants (45-74 years, 53.1% women) CAC percentiles at baseline (CACb) and after five years (CAC₅y) were evaluated, demonstrating progression along gender-specific percentiles, which showed exponentially shaped age-dependence. Using quantile regression on the log-scale (log(CACb+1)) we developed a tool to individually predict CAC₅y, and compared to observed CAC₅y...
November 7, 2014: European Heart Journal
Subhashish Agarwal, Amanda J Cox, David M Herrington, Neal W Jorgensen, Jianzhao Xu, Barry I Freedman, J Jeffrey Carr, Donald W Bowden
OBJECTIVE: In type 2 diabetes mellitus (T2DM), it remains unclear whether coronary artery calcium (CAC) provides additional information about cardiovascular disease (CVD) mortality beyond the Framingham Risk Score (FRS) factors. RESEARCH DESIGN AND METHODS: A total of 1,123 T2DM participants, ages 34-86 years, in the Diabetes Heart Study followed up for an average of 7.4 years were separated using baseline computed tomography scans of CAC (0-9, 10-99, 100-299, 300-999, and ≥1,000)...
April 2013: Diabetes Care
Jelena R Ghadri, Michael Fiechter, Katja Veraguth, Catherine Gebhard, Aju P Pazhenkottil, Tobias A Fuchs, Christian Templin, Oliver Gaemperli, Philipp A Kaufmann
UNLABELLED: The purpose of this study was to evaluate the added value of coronary artery calcium score (CACS) as an adjunct to myocardial perfusion imaging (MPI) with SPECT for cardiac risk stratification before noncardiac surgery. SPECT MPI is a well-established and widely used tool for preoperative risk stratification before noncardiac surgery. The potential added value of combining SPECT MPI with CACS is unknown. METHODS: We included 326 consecutive patients who were referred for SPECT MPI for preoperative cardiac risk assessment before elective noncardiac surgery...
July 2012: Journal of Nuclear Medicine: Official Publication, Society of Nuclear Medicine
Kimberly A Gudzune, Anne K Monroe, Ritu Sharma, Padmini D Ranasinghe, Yohalakshmi Chelladurai, Karen A Robinson
BACKGROUND: Some patients do not tolerate or respond to high-intensity statin monotherapy. Lower-intensity statin combined with nonstatin medication may be an alternative, but the benefits and risks compared with those of higher-intensity statin monotherapy are unclear. PURPOSE: To compare the clinical benefits, adherence, and harms of lower-intensity statin combination therapy with those of higher-intensity statin monotherapy among adults at high risk for atherosclerotic cardiovascular disease (ASCVD)...
April 1, 2014: Annals of Internal Medicine
Neil J Stone, Jennifer G Robinson, Alice H Lichtenstein, David C Goff, Donald M Lloyd-Jones, Sidney C Smith, Conrad Blum, J Sanford Schwartz
DESCRIPTION: In November 2013, the American College of Cardiology and American Heart Association (ACC/AHA) released a clinical practice guideline on the treatment of blood cholesterol to reduce cardiovascular risk in adults. This synopsis summarizes the major recommendations. METHODS: In 2008, the National Heart, Lung, and Blood Institute convened the Adult Treatment Panel (ATP) IV to update the 2001 ATP-III cholesterol guidelines using a rigorous process to systematically review randomized, controlled trials (RCTs) and meta-analyses of RCTs that examined cardiovascular outcomes...
March 4, 2014: Annals of Internal Medicine
John Downs, Chester Good
No abstract text is available yet for this article.
March 4, 2014: Annals of Internal Medicine
Seth S Martin, Roger S Blumenthal
No abstract text is available yet for this article.
March 4, 2014: Annals of Internal Medicine
John P A Ioannidis
No abstract text is available yet for this article.
February 5, 2014: JAMA: the Journal of the American Medical Association
Emmanouil S Brilakis, Vishal G Patel, Subhash Banerjee
IMPORTANCE: Percutaneous coronary intervention (PCI) with stents is currently the most commonly performed coronary revascularization procedure; hence, optimizing post-PCI outcomes is important for all physicians treating such patients. OBJECTIVE: To review the contemporary literature on optimal medical therapy after PCI. EVIDENCE REVIEW: We performed a comprehensive search of the PubMed and Cochrane Library databases for manuscripts on medical therapy after PCI, published between 2000 and February 2013...
July 10, 2013: JAMA: the Journal of the American Medical Association
Tjeerd-Pieter van Staa, Liam Smeeth, Edmond S-W Ng, Ben Goldacre, Martin Gulliford
OBJECTIVE: To evaluate targeting of statin prescribing for primary prevention to those with high cardiovascular disease (CVD) risk. DESIGN: Two cohort studies including the general population and initiators of statins aged 35-74 years. SETTING: UK primary care records in the Clinical Practice Research Datalink. PATIENTS: 3.8 million general population patients and 300 914 statin users. INTERVENTION: Statin prescribing...
November 2013: Heart: Official Journal of the British Cardiac Society
Earl S Ford
OBJECTIVES: The objective of this study was to examine trends in predicted 10-year risk for coronary heart disease (CHD) and cardiovascular disease (CVD) from 1999 to 2000 and from 2009 to 2010 among adults in the United States. BACKGROUND: Examining trends in predicted risk for CHD and CVD may offer insights into the direction of cardiovascular health. METHODS: Data from 7,751 fasting participants, ages 30 to 74 years, of 6 consecutive 2-year cycles of the National Health and Nutrition Examination Survey were used...
June 4, 2013: Journal of the American College of Cardiology
Bill Giannakopoulos, Steven A Krilis
This article discusses how we approach medical decision making in the treatment of the various facets of the antiphospholipid syndrome (APS), including secondary prophylaxis in the setting of venous and arterial thrombosis, as well as treatment for the prevention of recurrent miscarriages and fetal death. The role of primary thromboprophylaxis is also discussed in depth. Great emphasis is given to incorporating the most up-to-date and relevant evidence base both from the APS literature, and from large, recent, randomized controlled trials (RCTs) of primary and secondary thrombotic prophylaxis in the general population setting (ie, the population that has not been specifically investigated for APS)...
September 3, 2009: Blood
Paul M Ridker, Eleanor Danielson, Francisco A H Fonseca, Jacques Genest, Antonio M Gotto, John J P Kastelein, Wolfgang Koenig, Peter Libby, Alberto J Lorenzatti, Jean G MacFadyen, Børge G Nordestgaard, James Shepherd, James T Willerson, Robert J Glynn
BACKGROUND: Increased levels of the inflammatory biomarker high-sensitivity C-reactive protein predict cardiovascular events. Since statins lower levels of high-sensitivity C-reactive protein as well as cholesterol, we hypothesized that people with elevated high-sensitivity C-reactive protein levels but without hyperlipidemia might benefit from statin treatment. METHODS: We randomly assigned 17,802 apparently healthy men and women with low-density lipoprotein (LDL) cholesterol levels of less than 130 mg per deciliter (3...
November 20, 2008: New England Journal of Medicine
Jie J Cao, Alice M Arnold, Teri A Manolio, Joseph F Polak, Bruce M Psaty, Calvin H Hirsch, Lewis H Kuller, Mary Cushman
BACKGROUND: Carotid atherosclerosis, measured as carotid intima-media thickness or as characteristics of plaques, has been linked to cardiovascular disease (CVD) and to C-reactive protein (CRP) levels. We investigated the relationship between carotid atherosclerosis and CRP and their joint roles in CVD prediction. METHODS AND RESULTS: Of 5888 participants in the Cardiovascular Health Study, an observational study of adults aged > or = 65 years, 5020 without baseline CVD were included in the analysis...
July 3, 2007: Circulation
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