Andrea Lo Vecchio, Silvia Garazzino, Andrea Smarrazzo, Elisabetta Venturini, Marco Poeta, Paola Berlese, Marco Denina, Antonella Meini, Samantha Bosis, Luisa Galli, Salvatore Cazzato, Giangiacomo Nicolini, Gianluca Vergine, Roberta Giacchero, Giuseppina Ballardini, Icilio Dodi, Filippo Maria Salvini, Paolo Manzoni, Giuliana Ferrante, Vera Quadri, Andrea Campana, Raffaele Badolato, Alberto Villani, Alfredo Guarino, Guido Castelli Gattinara
Importance: Severe gastrointestinal (GI) manifestations have been sporadically reported in children with COVID-19; however, their frequency and clinical outcome are unknown. Objective: To describe the clinical, radiological, and histopathologic characteristics of children with COVID-19 presenting with severe GI manifestations to identify factors associated with a severe outcome. Design, Setting, and Participants: A multicenter retrospective cohort study (February 25, 2020, to January 20, 2021) enrolled inpatient and outpatient children (aged <18 years) with acute SARS-CoV-2 infection, confirmed by positive real-time reverse-transcriptase-polymerase chain reaction on nasopharyngeal swab or fulfilling the US Centers for Disease Control and Prevention criteria for multisystem inflammatory syndrome in children (MIS-C)...
December 1, 2021: JAMA Network Open