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COMMENT
Gary R Whittaker, Susan Daniel
No abstract text is available yet for this article.
July 2020: Nature
#22
EDITORIAL
Michael Levin
New England Journal of Medicine, Volume 383, Issue 4, Page 393-395, July 2020.
July 23, 2020: New England Journal of Medicine
#23
Leora R Feldstein, Erica B Rose, Steven M Horwitz, Jennifer P Collins, Margaret M Newhams, Mary Beth F Son, Jane W Newburger, Lawrence C Kleinman, Sabrina M Heidemann, Amarilis A Martin, Aalok R Singh, Simon Li, Keiko M Tarquinio, Preeti Jaggi, Matthew E Oster, Sheemon P Zackai, Jennifer Gillen, Adam J Ratner, Rowan F Walsh, Julie C Fitzgerald, Michael A Keenaghan, Hussam Alharash, Sule Doymaz, Katharine N Clouser, John S Giuliano, Anjali Gupta, Robert M Parker, Aline B Maddux, Vinod Havalad, Stacy Ramsingh, Hulya Bukulmez, Tamara T Bradford, Lincoln S Smith, Mark W Tenforde, Christopher L Carroll, Becky J Riggs, Shira J Gertz, Ariel Daube, Amanda Lansell, Alvaro Coronado Munoz, Charlotte V Hobbs, Kimberly L Marohn, Natasha B Halasa, Manish M Patel, Adrienne G Randolph
BACKGROUND: Understanding the epidemiology and clinical course of multisystem inflammatory syndrome in children (MIS-C) and its temporal association with coronavirus disease 2019 (Covid-19) is important, given the clinical and public health implications of the syndrome. METHODS: We conducted targeted surveillance for MIS-C from March 15 to May 20, 2020, in pediatric health centers across the United States. The case definition included six criteria: serious illness leading to hospitalization, an age of less than 21 years, fever that lasted for at least 24 hours, laboratory evidence of inflammation, multisystem organ involvement, and evidence of infection with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) based on reverse-transcriptase polymerase chain reaction (RT-PCR), antibody testing, or exposure to persons with Covid-19 in the past month...
June 29, 2020: New England Journal of Medicine
#24
Meagan E Deming, Nelson L Michael, Merlin Robb, Myron S Cohen, Kathleen M Neuzil
New England Journal of Medicine, Volume 383, Issue 10, September 2020.
September 3, 2020: New England Journal of Medicine
#25
Mark Barnes, Paul E Sax
No abstract text is available yet for this article.
June 18, 2020: New England Journal of Medicine
#26
MULTICENTER STUDY
David Ellinghaus, Frauke Degenhardt, Luis Bujanda, Maria Buti, Agustín Albillos, Pietro Invernizzi, Javier Fernández, Daniele Prati, Guido Baselli, Rosanna Asselta, Marit M Grimsrud, Chiara Milani, Fátima Aziz, Jan Kässens, Sandra May, Mareike Wendorff, Lars Wienbrandt, Florian Uellendahl-Werth, Tenghao Zheng, Xiaoli Yi, Raúl de Pablo, Adolfo G Chercoles, Adriana Palom, Alba-Estela Garcia-Fernandez, Francisco Rodriguez-Frias, Alberto Zanella, Alessandra Bandera, Alessandro Protti, Alessio Aghemo, Ana Lleo, Andrea Biondi, Andrea Caballero-Garralda, Andrea Gori, Anja Tanck, Anna Carreras Nolla, Anna Latiano, Anna Ludovica Fracanzani, Anna Peschuck, Antonio Julià, Antonio Pesenti, Antonio Voza, David Jiménez, Beatriz Mateos, Beatriz Nafria Jimenez, Carmen Quereda, Cinzia Paccapelo, Christoph Gassner, Claudio Angelini, Cristina Cea, Aurora Solier, David Pestaña, Eduardo Muñiz-Diaz, Elena Sandoval, Elvezia M Paraboschi, Enrique Navas, Félix García Sánchez, Ferruccio Ceriotti, Filippo Martinelli-Boneschi, Flora Peyvandi, Francesco Blasi, Luis Téllez, Albert Blanco-Grau, Georg Hemmrich-Stanisak, Giacomo Grasselli, Giorgio Costantino, Giulia Cardamone, Giuseppe Foti, Serena Aneli, Hayato Kurihara, Hesham ElAbd, Ilaria My, Iván Galván-Femenia, Javier Martín, Jeanette Erdmann, Jose Ferrusquía-Acosta, Koldo Garcia-Etxebarria, Laura Izquierdo-Sanchez, Laura R Bettini, Lauro Sumoy, Leonardo Terranova, Leticia Moreira, Luigi Santoro, Luigia Scudeller, Francisco Mesonero, Luisa Roade, Malte C Rühlemann, Marco Schaefer, Maria Carrabba, Mar Riveiro-Barciela, Maria E Figuera Basso, Maria G Valsecchi, María Hernandez-Tejero, Marialbert Acosta-Herrera, Mariella D'Angiò, Marina Baldini, Marina Cazzaniga, Martin Schulzky, Maurizio Cecconi, Michael Wittig, Michele Ciccarelli, Miguel Rodríguez-Gandía, Monica Bocciolone, Monica Miozzo, Nicola Montano, Nicole Braun, Nicoletta Sacchi, Nilda Martínez, Onur Özer, Orazio Palmieri, Paola Faverio, Paoletta Preatoni, Paolo Bonfanti, Paolo Omodei, Paolo Tentorio, Pedro Castro, Pedro M Rodrigues, Aaron Blandino Ortiz, Rafael de Cid, Ricard Ferrer, Roberta Gualtierotti, Rosa Nieto, Siegfried Goerg, Salvatore Badalamenti, Sara Marsal, Giuseppe Matullo, Serena Pelusi, Simonas Juzenas, Stefano Aliberti, Valter Monzani, Victor Moreno, Tanja Wesse, Tobias L Lenz, Tomas Pumarola, Valeria Rimoldi, Silvano Bosari, Wolfgang Albrecht, Wolfgang Peter, Manuel Romero-Gómez, Mauro D'Amato, Stefano Duga, Jesus M Banales, Johannes R Hov, Trine Folseraas, Luca Valenti, Andre Franke, Tom H Karlsen
BACKGROUND: There is considerable variation in disease behavior among patients infected with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), the virus that causes coronavirus disease 2019 (Covid-19). Genomewide association analysis may allow for the identification of potential genetic factors involved in the development of Covid-19. METHODS: We conducted a genomewide association study involving 1980 patients with Covid-19 and severe disease (defined as respiratory failure) at seven hospitals in the Italian and Spanish epicenters of the SARS-CoV-2 pandemic in Europe...
October 15, 2020: New England Journal of Medicine
#27
Bradley Hayes
The COVID-19 pandemic looks set to significantly change how we practice medicine. It is vital that the vulnerable and immunocompromised members of our workforce are protected, which may mean that they do not go into clinical areas. While the medical field has been slower than many professional areas to catch on to working from home, many trusts are already moving towards telephone or video outpatient appointments during COVID-19. We describe the equipment needed to set up working from home for healthcare practitioners (HCPs) and discuss a variety of other opportunities for home-based HCPs, including teaching, learning, carrying out audit and quality improvement work and offering psychological support for colleagues working on the front line...
June 2020: Future Healthcare Journal
#28
Bridget M Kuehn
No abstract text is available yet for this article.
June 16, 2020: JAMA
#29
Mandeep R Mehra, Sapan S Desai, Frank Ruschitzka, Amit N Patel
BACKGROUND: Hydroxychloroquine or chloroquine, often in combination with a second-generation macrolide, are being widely used for treatment of COVID-19, despite no conclusive evidence of their benefit. Although generally safe when used for approved indications such as autoimmune disease or malaria, the safety and benefit of these treatment regimens are poorly evaluated in COVID-19. METHODS: We did a multinational registry analysis of the use of hydroxychloroquine or chloroquine with or without a macrolide for treatment of COVID-19...
May 22, 2020: Lancet
#30
Renyi Zhang, Yixin Li, Annie L Zhang, Yuan Wang, Mario J Molina
Various mitigation measures have been implemented to fight the coronavirus disease 2019 (COVID-19) pandemic, including widely adopted social distancing and mandated face covering. However, assessing the effectiveness of those intervention practices hinges on the understanding of virus transmission, which remains uncertain. Here we show that airborne transmission is highly virulent and represents the dominant route to spread the disease. By analyzing the trend and mitigation measures in Wuhan, China, Italy, and New York City, from January 23 to May 9, 2020, we illustrate that the impacts of mitigation measures are discernable from the trends of the pandemic...
June 30, 2020: Proceedings of the National Academy of Sciences of the United States of America
#31
RANDOMIZED CONTROLLED TRIAL
John H Beigel, Kay M Tomashek, Lori E Dodd, Aneesh K Mehta, Barry S Zingman, Andre C Kalil, Elizabeth Hohmann, Helen Y Chu, Annie Luetkemeyer, Susan Kline, Diego Lopez de Castilla, Robert W Finberg, Kerry Dierberg, Victor Tapson, Lanny Hsieh, Thomas F Patterson, Roger Paredes, Daniel A Sweeney, William R Short, Giota Touloumi, David Chien Lye, Norio Ohmagari, Myoung-Don Oh, Guillermo M Ruiz-Palacios, Thomas Benfield, Gerd Fätkenheuer, Mark G Kortepeter, Robert L Atmar, C Buddy Creech, Jens Lundgren, Abdel G Babiker, Sarah Pett, James D Neaton, Timothy H Burgess, Tyler Bonnett, Michelle Green, Mat Makowski, Anu Osinusi, Seema Nayak, H Clifford Lane
BACKGROUND: Although several therapeutic agents have been evaluated for the treatment of coronavirus disease 2019 (Covid-19), no antiviral agents have yet been shown to be efficacious. METHODS: We conducted a double-blind, randomized, placebo-controlled trial of intravenous remdesivir in adults who were hospitalized with Covid-19 and had evidence of lower respiratory tract infection. Patients were randomly assigned to receive either remdesivir (200 mg loading dose on day 1, followed by 100 mg daily for up to 9 additional days) or placebo for up to 10 days...
November 5, 2020: New England Journal of Medicine
#32
Marc R Larochelle
New England Journal of Medicine, Volume 383, Issue 5, July 2020.
July 30, 2020: New England Journal of Medicine
#33
RANDOMIZED CONTROLLED TRIAL
Jason D Goldman, David C B Lye, David S Hui, Kristen M Marks, Raffaele Bruno, Rocio Montejano, Christoph D Spinner, Massimo Galli, Mi-Young Ahn, Ronald G Nahass, Yao-Shen Chen, Devi SenGupta, Robert H Hyland, Anu O Osinusi, Huyen Cao, Christiana Blair, Xuelian Wei, Anuj Gaggar, Diana M Brainard, William J Towner, Jose Muñoz, Kathleen M Mullane, Francisco M Marty, Karen T Tashima, George Diaz, Aruna Subramanian
BACKGROUND: Remdesivir is an RNA polymerase inhibitor with potent antiviral activity in vitro and efficacy in animal models of coronavirus disease 2019 (Covid-19). METHODS: We conducted a randomized, open-label, phase 3 trial involving hospitalized patients with confirmed SARS-CoV-2 infection, oxygen saturation of 94% or less while they were breathing ambient air, and radiologic evidence of pneumonia. Patients were randomly assigned in a 1:1 ratio to receive intravenous remdesivir for either 5 days or 10 days...
November 5, 2020: New England Journal of Medicine
#34
Soumya Sen, Pinar Karaca-Mandic, Archelle Georgiou
No abstract text is available yet for this article.
June 23, 2020: JAMA
#35
I Glenn Cohen, Lawrence O Gostin, Daniel J Weitzner
No abstract text is available yet for this article.
June 16, 2020: JAMA
#36
Joshua Geleris, Yifei Sun, Jonathan Platt, Jason Zucker, Matthew Baldwin, George Hripcsak, Angelena Labella, Daniel Manson, Christine Kubin, R Graham Barr, Magdalena E Sobieszczyk, Neil W Schluger
BACKGROUND: Hydroxychloroquine has been widely administered to patients with Covid-19 without robust evidence supporting its use. METHODS: We examined the association between hydroxychloroquine use and intubation or death at a large medical center in New York City. Data were obtained regarding consecutive patients hospitalized with Covid-19, excluding those who were intubated, died, or discharged within 24 hours after presentation to the emergency department (study baseline)...
May 7, 2020: New England Journal of Medicine
#37
REVIEW
Rajesh T Gandhi, John B Lynch, Carlos Del Rio
No abstract text is available yet for this article.
April 24, 2020: New England Journal of Medicine
#38
LETTER
Thomas J Oxley, J Mocco, Shahram Majidi, Christopher P Kellner, Hazem Shoirah, I Paul Singh, Reade A De Leacy, Tomoyoshi Shigematsu, Travis R Ladner, Kurt A Yaeger, Maryna Skliut, Jesse Weinberger, Neha S Dangayach, Joshua B Bederson, Stanley Tuhrim, Johanna T Fifi
New England Journal of Medicine, Volume 382, Issue 20, May 2020.
May 14, 2020: New England Journal of Medicine
#39
Ivry Zagury-Orly, Richard M Schwartzstein
New England Journal of Medicine, Volume 383, Issue 3, July 2020.
July 16, 2020: New England Journal of Medicine
#40
Eli N Perencevich, Daniel J Diekema, Michael B Edmond
No abstract text is available yet for this article.
June 9, 2020: JAMA
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