Constantinos Simillis, Amulya Khatri, Nick Dai, Thalia Afxentiou, Catherine Jephcott, Sarah Smith, Rashmi Jadon, Demetris Papamichael, Jim Khan, Michael P Powar, Nicola S Fearnhead, James Wheeler, Justin Davies
AIM: Multiple neoadjuvant therapy strategies have been used and compared for rectal cancer and there has been no true consensus as to the optimal neoadjuvant therapy regimen. The aim is to identify and compare the neoadjuvant therapies available for stage II and III rectal cancer. DESIGN: A systematic literature review was performed, from inception to August 2022, of the following databases: MEDLINE, EMBASE, Science Citation Index Expanded, Cochrane Library. Only randomized controlled trials comparing neoadjuvant therapies for stage II and III rectal cancer were considered...
March 2023: Critical Reviews in Oncology/hematology
Kushal T Kadakia, Adam L Beckman, Harlan M Krumholz
No abstract text is available yet for this article.
March 2023: Nature Medicine
Natalie Schudrowitz, C Patrick Shahan, Tovah Moss, John E Scarborough
BACKGROUND: Although strong evidence exists for combined mechanical and oral antibiotic bowel preparation before elective colorectal resection, the utility of preoperative bowel preparation for patients undergoing sigmoid resection after endoscopic decompression of sigmoid volvulus has not been previously examined. The goal of this study was to evaluate the association between bowel preparation and postoperative outcomes for patients undergoing semielective, same-admission sigmoid resection for acute volvulus...
April 1, 2023: Journal of the American College of Surgeons
James L Buxbaum, Martin Freeman, Stuart K Amateau, Jean M Chalhoub, Nayantara Coelho-Prabhu, Madhav Desai, Sherif E Elhanafi, Nauzer Forbes, Larissa L Fujii-Lau, Divyanshoo R Kohli, Richard S Kwon, Jorge D Machicado, Neil B Marya, Swati Pawa, Wenly H Ruan, Sunil G Sheth, Nikhil R Thiruvengadam, Nirav C Thosani, Bashar J Qumseya
No abstract text is available yet for this article.
December 12, 2022: Gastrointestinal Endoscopy
Claudia Zaharia, Kjetil Søreide
No abstract text is available yet for this article.
February 15, 2023: British Journal of Surgery
Tommaso Pollini, Paul Wong, Ajay V Maker
Modern series report a prevalence of pancreatic cysts in the general population of up to 50% in prospective studies. Of these, about half will be pancreatic cystic neoplasms (PCNs) that have varying degrees of malignant potential. Intraductal papillary mucinous neoplasms (IPMNs) of the pancreas are the most common PCNs and are known predecessors of pancreatic adenocarcinoma. Critically, they are one of the only radiographically identifiable precursors of pancreatic cancer and thus provide an opportunity for early cancer detection and surgical resection with curative intent...
March 2023: Annals of Surgical Oncology
Daichi Kitaguchi, Masaaki Ito
Complications after colorectal surgery remain inevitable, and anastomotic leakage is one of the most severe and potentially fatal complications. Generally, anastomotic leakage is associated with severe peritonitis, the need for emergency reoperation, and an increased mortality rate. Additionally, particularly after rectal cancer surgery, it has a negative impact on long-term outcomes, including postoperative anorectal function, local recurrence, and survival. To prevent anastomotic leakage, understanding the characteristics of each anastomotic technique and establishing a stable anastomotic procedure are important...
January 3, 2023: Annals of Coloproctology
Natasha L Larivée, Jacob B Michaud, Keigan M More, Jo-Anne Wilson, Karthik K Tennankore
It is well established that an elevated potassium level (hyperkalemia) is associated with a risk of adverse events including morbidity, mortality and healthcare system cost. Hyperkalemia is commonly encountered in many chronic conditions including kidney disease, diabetes and heart failure. Furthermore, hyperkalemia may result from the use of renin-angiotensin-aldosterone system inhibitors (RAASi), which are disease-modifying treatments for these conditions. Therefore, balancing the benefits of optimizing treatment with RAASi while mitigating hyperkalemia is crucial to ensure patients are optimally treated...
December 12, 2022: Cardiology and Therapy
Jennifer L Irani, Traci L Hedrick, Timothy E Miller, Lawrence Lee, Emily Steinhagen, Benjamin D Shogan, Joel E Goldberg, Daniel L Feingold, Amy L Lightner, Ian M Paquette
The American Society of Colon and Rectal Surgeons (ASCRS) and the Society of American Gastrointestinal and Endoscopic Surgeons (SAGES) are dedicated to ensuring high-quality innovative patient care for surgical patients by advancing the science, prevention, and management of disorders and diseases of the colon, rectum, and anus as well as minimally invasive surgery. The ASCRS and SAGES society members involved in the creation of these guidelines were chosen because they have demonstrated expertise in the specialty of colon and rectal surgery and enhanced recovery...
January 2023: Surgical Endoscopy
Ameish Govindarajan
No abstract text is available yet for this article.
March 10, 2023: Journal of Clinical Oncology
Marco Vincenzo Lenti, Sarah Luu, Rita Carsetti, Faith Osier, Rodney Ogwang, Obiageli E Nnodu, Ursula Wiedermann, Jo Spencer, Franco Locatelli, Gino Roberto Corazza, Antonio Di Sabatino
Asplenia (the congenital or acquired absence of the spleen) and hyposplenism (defective spleen function) are common causes of morbidity and mortality. The spleen is a secondary lymphoid organ that is responsible for the regulation of immune responses and blood filtration. Hence, asplenia or hyposplenism increases susceptibility to severe and invasive infections, especially those sustained by encapsulated bacteria (namely, Neisseria meningitidis, Streptococcus pneumoniae, Haemophilus influenzae type b). Asplenia is predominantly due to splenectomy for either traumatic events or oncohaematological conditions...
November 3, 2022: Nature Reviews. Disease Primers
Matthew A Beier, Catherine H Davis, Maria G Fencer, Miral S Grandhi, Henry A Pitt, David A August
BACKGROUND: Prior studies of older cancer patients undergoing large operations have reported similar rates of complications to the general population but higher rates of mortality, suggesting higher rates of failure-to-rescue (FTR) with advanced age. Whether age is a marker for frailty, or an independent predictor of FTR, is not clear. METHODS: The ACS-NSQIP database was queried from 2015-19 for patients undergoing surgery for gastrointestinal (GI) malignancy. Patients were divided into age-stratified cohorts: C1 (18-55), C2 (56-65), C3 (66-75), C4 (76-89)...
February 2023: Annals of Surgical Oncology
(no author information available yet)
The sixth edition of the Japanese Gastric Cancer Treatment Guidelines was completed in July 2021, incorporating new evidence that emerged after publication of the previous edition. It consists of a text-based "Treatments" part and a "Clinical Questions" part including recommendations and explanations for clinical questions. The treatments parts include a comprehensive description regarding surgery, endoscopic resection and chemotherapy for gastric cancer. The clinical question part is based on the literature search and evaluation by an independent systematic review team...
November 7, 2022: Gastric Cancer
Karolina Gimberg, Lars Enochsson, Gabriel Sandblom
No abstract text is available yet for this article.
July 17, 2023: British Journal of Surgery
(no author information available yet)
BACKGROUND: Surgical site infection (SSI) remains the most common complication of surgery around the world. WHO does not make recommendations for changing gloves and instruments before wound closure owing to a lack of evidence. This study aimed to test whether a routine change of gloves and instruments before wound closure reduced abdominal SSI. METHODS: ChEETAh was a multicentre, cluster randomised trial in seven low-income and middle-income countries (Benin, Ghana, India, Mexico, Nigeria, Rwanda, South Africa)...
November 19, 2022: Lancet
Chad G Ball, Alex Lee, Matthew Kaminsky, S Morad Hameed
Penetrating cardiac injuries require rapid diagnosis, efficient exposure and nuanced technical approaches, within a framework of highly coordinated and integrated multidisciplinary care. Acute care surgeons, with both strategic and technical expertise, are ideally positioned to address the potentially devastating consequences of these injuries. The aim of this narrative review is to offer a technical approach to the rapid evaluation, exposure, operative repair and postoperative care of penetrating cardiac injuries...
2022: Canadian Journal of Surgery. Journal Canadien de Chirurgie
Miklosh Bala, Fausto Catena, Jeffry Kashuk, Belinda De Simone, Carlos Augusto Gomes, Dieter Weber, Massimo Sartelli, Federico Coccolini, Yoram Kluger, Fikri M Abu-Zidan, Edoardo Picetti, Luca Ansaloni, Goran Augustin, Walter L Biffl, Marco Ceresoli, Osvaldo Chiara, Massimo Chiarugi, Raul Coimbra, Yunfeng Cui, Dimitris Damaskos, Salomone Di Saverio, Joseph M Galante, Vladimir Khokha, Andrew W Kirkpatrick, Kenji Inaba, Ari Leppäniemi, Andrey Litvin, Andrew B Peitzman, Vishal G Shelat, Michael Sugrue, Matti Tolonen, Sandro Rizoli, Ibrahima Sall, Solomon G Beka, Isidoro Di Carlo, Richard Ten Broek, Chirika Mircea, Giovanni Tebala, Michele Pisano, Harry van Goor, Ronald V Maier, Hans Jeekel, Ian Civil, Andreas Hecker, Edward Tan, Kjetil Soreide, Matthew J Lee, Imtiaz Wani, Luigi Bonavina, Mark A Malangoni, Kaoru Koike, George C Velmahos, Gustavo P Fraga, Andreas Fette, Nicola de'Angelis, Zsolt J Balogh, Thomas M Scalea, Gabriele Sganga, Michael D Kelly, Jim Khan, Philip F Stahel, Ernest E Moore
Acute mesenteric ischemia (AMI) is a group of diseases characterized by an interruption of the blood supply to varying portions of the intestine, leading to ischemia and secondary inflammatory changes. If untreated, this process may progress to life-threatening intestinal necrosis. The incidence is low, estimated at 0.09-0.2% of all acute surgical admissions, but increases with age. Although the entity is an uncommon cause of abdominal pain, diligence is required because if untreated, mortality remains in the range of 50%...
October 19, 2022: World Journal of Emergency Surgery: WJES
Peter Szatmary, Tassos Grammatikopoulos, Wenhao Cai, Wei Huang, Rajarshi Mukherjee, Chris Halloran, Georg Beyer, Robert Sutton
Acute pancreatitis is a common indication for hospital admission, increasing in incidence, including in children, pregnancy and the elderly. Moderately severe acute pancreatitis with fluid and/or necrotic collections causes substantial morbidity, and severe disease with persistent organ failure causes significant mortality. The diagnosis requires two of upper abdominal pain, amylase/lipase ≥ 3 ×upper limit of normal, and/or cross-sectional imaging findings. Gallstones and ethanol predominate while hypertriglyceridaemia and drugs are notable among many causes...
September 8, 2022: Drugs
Zaiba Shafik Dawood, Laura Alaimo, Henrique A Lima, Zorays Moazzam, Chanza Shaikh, Ahmed Sayed Ahmed, Muhammad Musaab Munir, Yutaka Endo, Timothy M Pawlik
BACKGROUND: Almost one-third of colorectal cancer (CRC) patients experience recurrence after resection; nevertheless, follow-up strategies remain controversial. We sought to systematically assess and compare the accuracy of carcinoembryonic antigen (CEA), imaging [positron emission tomography (PET) and computed tomography (CT) scans], and circulating tumor DNA (CtDNA) as surveillance strategies. PATIENTS AND METHODS: PubMed, Medline, Embase, Scopus, Cochrane, Web of Science, and CINAHL were systematically searched...
January 2023: Annals of Surgical Oncology
Ronnie Fass
New England Journal of Medicine, Volume 387, Issue 13, Page 1207-1216, September 2022.
September 29, 2022: New England Journal of Medicine
2022-10-06 16:26:39
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