Huseyin Naci, Aaron S Kesselheim, John-Arne Røttingen, Georgia Salanti, Per O Vandvik, Andrea Cipriani
No abstract text is available yet for this article.
October 16, 2020: BMJ: British Medical Journal
Khai Li Chai, Sarah J Valk, Vanessa Piechotta, Catherine Kimber, Ina Monsef, Carolyn Doree, Erica M Wood, Abigail A Lamikanra, David J Roberts, Zoe McQuilten, Cynthia So-Osman, Lise J Estcourt, Nicole Skoetz
BACKGROUND: Convalescent plasma and hyperimmune immunoglobulin may reduce mortality in patients with viral respiratory diseases, and are currently being investigated in trials as potential therapy for coronavirus disease 2019 (COVID-19). A thorough understanding of the current body of evidence regarding the benefits and risks is required.  OBJECTIVES: To continually assess, as more evidence becomes available, whether convalescent plasma or hyperimmune immunoglobulin transfusion is effective and safe in treatment of people with COVID-19...
October 12, 2020: Cochrane Database of Systematic Reviews
Mohamad El Moheb, Ava Mokhtari, Kelsey Han, Inge van Erp, Napaporn Kongkaewpaisan, Zhenyi Jia, Gabriel Rodriguez, Manasnun Kongwibulwut, Haytham Ma Kaafarani
BACKGROUND: Patients in the US receive disproportionally higher amounts of opioids following surgery compared to their non-US counterparts. We aimed to assess the relationship between perceived pain severity after surgery and the amount of opioid medications prescribed at discharge in US vs. non-US patients. METHODS: We conducted a post-hoc analysis of the International Patterns of Opioid Prescribing (iPOP) multicenter study. Patients aged 16 and older who underwent appendectomy, cholecystectomy, or inguinal herniorrhaphy in one of 14 participating hospitals across 8 countries between October 2016 and March 2017 were included...
September 22, 2020: Journal of the American College of Surgeons
J Wayne Meredith, Kevin P High, Julie Ann Freischlag
No abstract text is available yet for this article.
October 5, 2020: JAMA
Joo Hyun Oh, Dong Hyun Sinn, Gyu-Seong Choi, Jong Man Kim, Jae-Won Joh, Tae Wook Kang, Dongho Hyun, Wonseok Kang, Geum-Youn Gwak, Yong-Han Paik, Joon Hyeok Lee, Kwang Cheol Koh, Seung Woon Paik, Moon Seok Choi
Purpose: Although surgical resection is usually considered for a single tumor, several reports have suggested that resection can be considered for multiple tumors. The objective of this study was to determine whether resection could provide better long-term outcome for patients with multiple hepatocellular carcinomas (HCCs) within Milan criteria. Methods: A total of 276 patients with multiple HCCs within Milan criteria with liver function preserved who underwent resection, radiofrequency ablation (RFA), or transarterial chemoembolization (TACE) between 2009 and 2013 were analyzed...
October 2020: Annals of Surgical Treatment and Research
Jordan M Cloyd, George A Poultsides
Pancreatic neuroendocrine tumors (PNETs) comprise a heterogeneous group of neoplasms arising from pancreatic islet cells that remain relatively rare but are increasing in incidence worldwide. While significant advances have been made in recent years with regard to systemic therapies for patients with advanced disease, surgical resection remains the standard of care for most patients with localized tumors. Although formal pancreatectomy with regional lymphadenectomy is the standard approach for most PNETs, pancreas-preserving approaches without formal lymphadenectomy are acceptable for smaller tumors at low risk for lymph node metastases...
September 18, 2020: Annals of Surgical Oncology
Feredun S Azari, Charles M Vollmer, Robert E Roses, Luke Keele, Ronald P DeMatteo, Jeffrey A Drebin, Major Kenneth Lee
BACKGROUND: Periampullary malignancies are often unresectable tumors that frequently cause biliary or duodenal obstruction. Advances in endoscopic and percutaneous options have lessened the need for operative palliation. Nevertheless, many patients are still found to be unresectable at the time of exploration, making palliative bypass a consideration. Several prior studies have examined the morbidity of operative palliation, but many were conducted over lengthy time periods, and few have examined the impact of these procedures on future therapy...
September 1, 2020: Surgery
François Lamontagne, Thomas Agoritsas, Helen Macdonald, Yee-Sin Leo, Janet Diaz, Arnav Agarwal, John Adabie Appiah, Yaseen Arabi, Lucille Blumberg, Carolyn S Calfee, Bin Cao, Maurizio Cecconi, Graham Cooke, Jake Dunning, Heike Geduld, Patrick Gee, Hela Manai, David S Hui, Seema Kanda, Leticia Kawano-Dourado, Yae-Jean Kim, Niranjan Kissoon, Arthur Kwizera, Jon Henrik Laake, Flavia R Machado, Nida Qadir, Rohit Sarin, Yinzhong Shen, Linan Zeng, Romina Brignardello-Petersen, Lyubov Lytvyn, Reed Siemieniuk, Dena Zeraatkar, Jessica Bartoszko, Long Ge, Brittany Maguire, Bram Rochwerg, Gordon Guyatt, Per Olav Vandvik
CLINICAL QUESTION: What is the role of drug interventions in the treatment and prevention of covid-19? RECOMMENDATIONS: The first version on this living guidance focuses on corticosteroids. It contains a strong recommendation for systemic corticosteroids in patients with severe and critical covid-19, and a weak or conditional recommendation against systemic corticosteroids in patients with non-severe covid-19. Corticosteroids are inexpensive and are on the World Health Organisation list of essential medicines...
September 4, 2020: BMJ: British Medical Journal
Lisa Duffett, Lana A Castellucci, Melissa A Forgie
Pulmonary embolism is a common and potentially fatal cardiovascular disorder that must be promptly diagnosed and treated. The diagnosis, risk assessment, and management of pulmonary embolism have evolved with a better understanding of efficient use of diagnostic and therapeutic options. The use of either clinical probability adjusted or age adjusted D-dimer interpretation has led to a reduction in diagnostic imaging to exclude pulmonary embolism. Direct oral anticoagulation therapies are safe, effective, and convenient treatments for most patients with acute venous thromboembolism, with a lower risk of bleeding than vitamin K antagonists...
August 5, 2020: BMJ: British Medical Journal
Georgios Antonios Margonis, Nikolaos Andreatos, Murray F Brennan
No abstract text is available yet for this article.
August 31, 2020: Annals of Surgical Oncology
Oscar J Manrique, Samyd S Bustos, Pedro Ciudad, Kian Adabi, Wei F Chen, Antonio J Forte, Andrea L Cheville, James W Jakub, Sarah A McLaughlin, Hung-Chi Chen
Lymphedema has historically been underrated in clinical practice, education, and scholarship to the detriment of many patients with this chronic, debilitating condition. The mechanical insufficiency of the lymphatic system causes the abnormal accumulation of protein-rich fluid in the interstitium, which triggers a cascade of adverse consequences such as fat deposition and fibrosis. As the condition progresses, patients present with extremity heaviness, itchiness, skin infections, and, in later stages, dermal fibrosis, skin papillomas, acanthosis, and other trophic skin changes...
August 20, 2020: Mayo Clinic Proceedings
Vikas N O'Reilly-Shah, Katherine R Gentry, Andrew M Walters, Joel Zivot, Corrie T Anderson, Patrick J Tighe
No abstract text is available yet for this article.
August 21, 2020: British Journal of Anaesthesia
Willemijn L A Schäfer, Jonah J Stulberg
No abstract text is available yet for this article.
July 29, 2020: American Journal of Surgery
Danielle M H Beurskens, Joram P Huckriede, Roy Schrijver, H Coenraad Hemker, Chris P Reutelingsperger, Gerry A F Nicolaes
Heparins represent one of the most frequently used pharmacotherapeutics. Discovered around 1926, routine clinical anticoagulant use of heparin was initiated only after the publication of several seminal papers in the early 1970s by the group of Kakkar. It was shown that heparin prevents venous thromboembolism and mortality from pulmonary embolism in patients after surgery. With the subsequent development of low-molecular-weight heparins and synthetic heparin derivatives, a family of related drugs was created that continues to prove its clinical value in thromboprophylaxis and in prevention of clotting in extracorporeal devices...
August 20, 2020: Thrombosis and Haemostasis
Georg Beyer, Aida Habtezion, Jens Werner, Markus M Lerch, Julia Mayerle
Chronic pancreatitis is a multifactorial, fibroinflammatory syndrome in which repetitive episodes of pancreatic inflammation lead to extensive fibrotic tissue replacement, resulting in chronic pain, exocrine and endocrine pancreatic insufficiency, reduced quality of life, and a shorter life expectancy. The incidence and prevalence of chronic pancreatitis is rising and no curative treatment is available. Using novel diagnostic algorithms, definitive chronic pancreatitis can be diagnosed by imaging criteria alone, whereas probable chronic pancreatitis requires clinical features and imaging criteria...
August 15, 2020: Lancet
Lee Kirksey, Tushar Vacharajani, Nathan M Droz, Gordon McLennan, Daniel Clair, Sean P Lyden
No abstract text is available yet for this article.
August 13, 2020: Journal of Vascular Surgery
Koemil Mirzaei Baboli, Henry Liu, Juan Lucas Poggio
No abstract text is available yet for this article.
July 2020: Current Problems in Surgery
Komeil Mirzaei Baboli, Henry Liu, Juan L Poggio
No abstract text is available yet for this article.
July 2020: Current Problems in Surgery
Truman J Milling, Charles V Pollack
Anticoagulation is key to the treatment/prevention of thromboembolic events. The primary complication of anticoagulation is serious or life-threatening hemorrhage, which may necessitate prompt anticoagulation reversal; this could also be required for nonbleeding patients requiring urgent/emergent invasive procedures. The decision to reverse anticoagulation should weigh the benefit-risk ratio of supporting hemostasis versus post-reversal thrombosis. We appraise the available guidelines/recommendations for vitamin K antagonist (VKA) and direct oral anticoagulant (DOAC) reversal in the management of major bleeding, and also assess recent clinical data that may not yet be reflected in official guidance...
September 2020: American Journal of Emergency Medicine
Davendra P S Sohal, Erin B Kennedy, Pelin Cinar, Thierry Conroy, Mehmet S Copur, Christopher H Crane, Ignacio Garrido-Laguna, Michelle W Lau, Tyler Johnson, Smitha Krishnamurthi, Cassadie Moravek, Eileen M O'Reilly, Philip A Philip, Shubham Pant, Manish A Shah, Vaibhav Sahai, Hope E Uronis, Neeha Zaidi, Daniel Laheru
PURPOSE: The aim of this work was to provide an update to the ASCO guideline on metastatic pancreatic cancer pertaining to recommendations for therapy options after first-line treatment. METHODS: ASCO convened an Expert Panel and conducted a systematic review to update guideline recommendations for second-line therapy for metastatic pancreatic cancer. RESULTS: One randomized controlled trial of olaparib versus placebo, one report on phase I and II studies of larotrectinib, and one report on phase I and II studies of entrectinib met the inclusion criteria and inform the guideline update...
August 5, 2020: Journal of Clinical Oncology: Official Journal of the American Society of Clinical Oncology
2020-08-14 19:41:30
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