Tara O Henderson, Preetha Rajaraman, Marilyn Stovall, Louis S Constine, Aliza Olive, Susan A Smith, Ann Mertens, Anna Meadows, Joseph P Neglia, Sue Hammond, John Whitton, Peter D Inskip, Leslie L Robison, Lisa Diller
PURPOSE: Childhood cancer survivors have an increased risk of secondary sarcomas. To better identify those at risk, the relationship between therapeutic dose of chemotherapy and radiation and secondary sarcoma should be quantified. METHODS AND MATERIALS: We conducted a nested case-control study of secondary sarcomas (105 cases, 422 matched controls) in a cohort of 14,372 childhood cancer survivors. Radiation dose at the second malignant neoplasm (SMN) site and use of chemotherapy were estimated from detailed review of medical records...
September 1, 2012: International Journal of Radiation Oncology, Biology, Physics