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Renal Tx

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357 papers 100 to 500 followers
By Isabel Acosta-Ochoa Nephrology senior staff. Valladolid. Spain
Adriana J van Ballegooijen, Joline W J Beulens, Charlotte A Keyzer, Gerjan J Navis, Stefan P Berger, Martin H de Borst, Marc G Vervloet, Stephan J L Bakker
Background: Kidney transplant recipients (KTRs) experience substantial survival benefit compared with dialysis patients. However, their mortality and graft failure risk remain high. KTRs are often low in micronutrient status, including vitamins D and K. We investigated the association of both vitamins D and K status, and vitamin D treatment with all-cause mortality and death-censored graft failure. Methods: We studied 461 KTRs from a single-centre study at median 6...
February 12, 2019: Nephrology, Dialysis, Transplantation
Hideyo Oguchi, Ken Sakai, Yutaka Yamaguchi, Tetuo Mikami, Tetsuo Nemoto, Yasushi Ohashi, Takeshi Kawamura, Masaki Muramatsu, Yoshihiro Itabashi, Kazunobu Shinoda, Yoji Hyodo, Yusuke Takahashi, Yuki Kawaguchi, Hiroka Onishi, Yuko Hamasaki, Kazutoshi Shibuya, Seiichiro Shishido
AIM: We examined the clinicopathologic significance of hyalinosis in the vasa recta in the medulla of allograft kidney biopsies. METHOD: We analyzed biopsy specimens from January 2010 to December 2015, obtained from both the cortex and medulla (including the vasa recta) ≥ 1 year after living-donor kidney transplantation. We excluded biopsy specimens from recipients who had undergone transplantation due to diabetic nephropathy or who had diabetes mellitus after transplantation...
February 8, 2019: Clinical and Experimental Nephrology
Jesse D Schold
No abstract text is available yet for this article.
January 30, 2019: Transplantation
Deepika Jain, Danny B Haddad, Narender Goel
The population of patients with end stage renal disease (ESRD) is increasing, lengthening waiting lists for kidney transplantation. Majority of the patients are not able to receive a kidney transplant in timely manner even though it is well established that patient survival and quality of life after kidney transplantation is far better when compared to being on dialysis. A large number of patients who desire a kidney transplant ultimately end up needing some form of dialysis therapy. Most of incident ESRD patients choose hemodialysis (HD) over peritoneal dialysis (PD) as the modality of choice in the United States, even though studies have favored PD as a better choice of pre-transplant dialysis modality than HD...
January 21, 2019: World Journal of Nephrology
(no author information available yet)
No abstract text is available yet for this article.
February 2019: Transplantation
Nadia M Chu, Alden L Gross, Ashton A Shaffer, Christine E Haugen, Silas P Norman, Qian-Li Xue, A Richey Sharrett, Michelle C Carlson, Karen Bandeen-Roche, Dorry L Segev, Mara A McAdams-DeMarco
BACKGROUND: Restoration of kidney function after kidney transplant generally improves cognitive function. It is unclear whether frail recipients, with higher susceptibility to surgical stressors, achieve such post-transplant cognitive improvements or whether they experience subsequent cognitive decline as they age with a functioning graft. METHODS: In this two-center cohort study, we assessed pretransplant frailty (Fried physical frailty phenotype) and cognitive function (Modified Mini-Mental State Examination) in adult kidney transplant recipients...
January 24, 2019: Journal of the American Society of Nephrology: JASN
Ulrich Rother, Kerstin Amann, Werner Adler, Nina Nawroth, Ioannis Karampinis, Michael Keese, Serhat Manap, Susanne Regus, Alexander Meyer, Stefan Porubsky, Karl Hilgers, Bernhard K Krämer, Werner Lang, Kai Nowak, Andreas L H Gerken
OBJECTIVE: Indocyanine green fluorescence angiography enables a quantitative real-time perfusion assessment in kidney transplantation. The results of intraoperative microperfusion of the kidney allograft were compared to the renal chronicity score in pre-transplantation kidney biopsy specimens. The intrarenal resistance index was calculated by duplex sonography as a method of reference. METHODS: Seventy-seven patients with end stage renal disease undergoing kidney transplantation were prospectively included in two centers...
January 17, 2019: Microcirculation: the Official Journal of the Microcirculatory Society, Inc
Nina Mann, Daniela A Braun, Kassaundra Amann, Weizhen Tan, Shirlee Shril, Dervla M Connaughton, Makiko Nakayama, Ronen Schneider, Thomas M Kitzler, Amelie T van der Ven, Jing Chen, Hadas Ityel, Asaf Vivante, Amar J Majmundar, Ankana Daga, Jillian K Warejko, Svjetlana Lovric, Shazia Ashraf, Tilman Jobst-Schwan, Eugen Widmeier, Hannah Hugo, Shrikant M Mane, Leslie Spaneas, Michael J G Somers, Michael A Ferguson, Avram Z Traum, Deborah R Stein, Michelle A Baum, Ghaleb H Daouk, Richard P Lifton, Shannon Manzi, Khashayar Vakili, Heung Bae Kim, Nancy M Rodig, Friedhelm Hildebrandt
BACKGROUND: Whole-exome sequencing (WES) finds a CKD-related mutation in approximately 20% of patients presenting with CKD before 25 years of age. Although provision of a molecular diagnosis could have important implications for clinical management, evidence is lacking on the diagnostic yield and clinical utility of WES for pediatric renal transplant recipients. METHODS: To determine the diagnostic yield of WES in pediatric kidney transplant recipients, we recruited 104 patients who had received a transplant at Boston Children's Hospital from 2007 through 2017, performed WES, and analyzed results for likely deleterious variants in approximately 400 genes known to cause CKD...
January 17, 2019: Journal of the American Society of Nephrology: JASN
Patrizia Calella, Sonsoles Hernández-Sánchez, Carlo Garofalo, Jonatan R Ruiz, Juan J Carrero, Vincenzo Bellizzi
BACKGROUND AND AIMS: Evidences on the benefits of physical exercise in kidney transplant patients (KTx) are not conclusive and concerns on safety remain. We here gather and interpret current evidence on the benefits/harms of exercise training intervention in KTx. METHODS: Systematic review of exercise training programs in KTx. RESULTS: A total of 24 studies including 654 KTx patients on intervention and 536 controls were evaluated. The median age was 46 years; the transplant vintage was 2 days to 10 years...
January 16, 2019: Journal of Nephrology
Hira Lal, Ezaz Mohamed, Neelam Soni, Priyank Yadav, Manoj Jain, Dharmendra Bhadauria, Anupma Kaul, Narayan Prasad, Amit Gupta, R K Sharma
Early graft dysfunction after renal transplantation manifests as acute rejection (AR) or acute tubular necrosis (ATN). Blood oxygen level-dependent (BOLD) magnetic resonance (MR) imaging is a noninvasive method of assessing tissue oxygenation, which may be useful for predicting acute allograft dysfunction. This was a prospective study involving 40 patients scheduled for renal transplantation from August 2012 to August 2014. In addition, 15 healthy donors were also enrolled in this study. All recipients underwent BOLD MR imaging (MRI) and R2* mapping 10-20 days after transplant, and additionally within 48 h of biopsy if there was any evidence of graft dysfunction...
November 2018: Indian Journal of Nephrology
Stephanie F Smith, Sarah A Hosgood, Michael L Nicholson
Renal ischemia-reperfusion injury (IRI) is a significant clinical challenge faced by clinicians perioperatively in kidney transplantation. Recent work has demonstrated the key importance of transmembrane receptors in the injured tubular epithelial cell, most notably Toll-like receptors, activated by exogenous and endogenous ligands in response to external and internal stresses. Through sequential protein-protein interactions, the signal is relayed deep into the core physiological machinery of the cell, having numerous effects from upregulation of pro-inflammatory gene products through to modulating mitochondrial respiration...
January 2019: Kidney International
John S Gill
No abstract text is available yet for this article.
December 28, 2018: Clinical Journal of the American Society of Nephrology: CJASN
C Cousineau, T Kumar, J P Roszka, K L Lewinski, W Li, H D Kanaan, R Pullalarevu, D S Bedi, S R Cohn, D Samarapungavan, Ping L Zhang
INTRODUCTION: Frozen sections have been used for evaluating tumors and margins during daily practice in pathology with high specificity and sensitivity (>90% for both indices both at national level and in our department). The correlation between frozen section tissue for immunofluorescent (IF) studies and permanent sections for light microscopy, along with electron microscopy, is critical for constructing a final renal pathology diagnosis. METHODS: We studied the correlation between the frozen sections for IF studies and separate fragments of tissue for permanent light microscopic sections in our renal transplant biopsies for purposes of quality control...
December 2018: Transplantation Proceedings
Sandesh Parajuli, Didier A Mandelbrot, Fahad Aziz, Neetika Garg, Brenda Muth, Maha Mohamed, Michael J Armbrust, Brad C Astor, Arjang Djamali
Background: Information regarding the clinical characteristics and outcomes of kidney transplant recipients (KTRs) with > 25 years of graft survival is limited. Methods: In this single-center observational study, we characterized KTRs transplanted between 1973 and 1992 with active follow-up as of July 31, 2017. Results: We identified 112 patients with > 25 years of allograft function. The mean posttransplantation follow-up was 29.8 ± 4...
November 2018: Kidney Diseases
Stephanie Preuss, Charlotte Rother, Lutz Renders, Stefan Wagenpfeil, Maike Büttner-Herold, Julia Slotta-Huspenina, Christopher Holtzmann, Claudius Kuechle, Uwe Heemann, Konrad Friedrich Stock
INTRODUCTION: Allograft rejection (AR), chronic allograft injury (CAI) and acute tubular necrosis (ATN) can lead to renal allograft dysfunction after kidney transplantation. Interstitial fibrosis/tubular atrophy (Banff classification 2005) describes chronic allograft injury with no specific etiology, thus explaining the common final endpoint of various (immunologic and non immunologic) etiologies. The aim of this study was to evaluate correlations between the Doppler sonographic RI-values and histopathological changes of renal allografts biopsies during rejection, acute tubular necrosis and chronic allograft injury as well as the influence of donor and recipient features on the intrarenal RI-values...
December 12, 2018: Clinical Hemorheology and Microcirculation
Ashwani K Singal, Song Ong, Sanjaya Satpathy, Patrick S Kamath, Russel H Wiesner
Kidney injury is frequently seen in patients with end stage liver disease from cirrhosis and liver failure. Among select patients, simultaneous liver kidney (SLK) transplantation provides improved post-transplant graft and patient outcomes compared to liver transplantation alone. We conducted review of the existing literature on SLK transplant criteria and outcomes. Since the introduction of the model for end-stage disease score in 2002, there has been an increased use of simultaneous liver kidney transplantation...
December 10, 2018: Transplant International: Official Journal of the European Society for Organ Transplantation
Nordeval Cavalcante Araújo, José Hermógenes Rocco Suassuna
BACKGROUND: Contrast enhanced ultrasonography (CEUS) assessment of kidney allografts mainly focuses on graft rejection. However, studies on delayed graft function (DGF) without acute rejection are still lacking. The aim of this study was to build a time-intensity curve (TIC) using CEUS in non-immunological DGF to understand the utility of CEUS in early transplantation. METHODS: Twenty-eight patients in the short-term postoperative period (<14 days) were divided according to the need for dialysis (early graft function [EGF] and [DGF]) and 37 subjects with longer than 90 days follow-up were divided into creatinine tertiles...
December 11, 2018: BMC Nephrology
Tiffany Wong, Roy D Bloom
The prevalence of hepatitis C virus infection is increased in patients with end stage kidney disease compared to the general population and is an adverse outcome determinant. Direct-acting antiviral therapy for hepatitis C virus is changing the management paradigm of infected kidney transplant candidates and recipients, with potential to reduce patient morbidity and mortality. This review describes the hepatic and nonhepatic manifestations of hepatitis C virus in kidney transplant patients as well as management and treatment strategies to optimize transplant outcomes, highlighting the importance of direct-acting antivirals in this population...
December 9, 2018: Seminars in Dialysis
Xue Li, Jinsong Chen, Dongrui Cheng, Rong Wang, Wei Wang, Mingchao Zhang, Feng Xu, Jiqiu Wen, Zheng Tang
BACKGROUND/AIMS: We aimed to explore the associations between clinical parameters and long-term allograft outcomes in transplant glomerulopathy (TG) in a large retrospective cohort with long follow-up. METHODS: Clinical and laboratory data at biopsy from 180 cases of TG with an estimated glomerular filtration rate (eGFR)> 15ml/min/1.73m2 from January 2004 to December 2016 at our center were retrospectively analyzed. The main outcome of this study was initiation of replacement therapy or an eGFR declined to < 15 ml/min/1...
December 7, 2018: Kidney & Blood Pressure Research
Deirdre Sawinski
No abstract text is available yet for this article.
October 2018: American Journal of Transplantation
2018-12-05 12:21:38
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