Camille E Powe, Michele K Evans, Julia Wenger, Alan B Zonderman, Anders H Berg, Michael Nalls, Hector Tamez, Dongsheng Zhang, Ishir Bhan, S Ananth Karumanchi, Neil R Powe, Ravi Thadhani
BACKGROUND: Low levels of total 25-hydroxyvitamin D are common among black Americans. Vitamin D-binding protein has not been considered in the assessment of vitamin D deficiency. METHODS: In the Healthy Aging in Neighborhoods of Diversity across the Life Span cohort of blacks and whites (2085 participants), we measured levels of total 25-hydroxyvitamin D, vitamin D-binding protein, and parathyroid hormone as well as bone mineral density (BMD). We genotyped study participants for two common polymorphisms in the vitamin D-binding protein gene (rs7041 and rs4588)...
November 21, 2013: New England Journal of Medicine