Naiara Martinez-Velez, Enric Xipell, Patricia Jauregui, Marta Zalacain, Lucía Marrodan, Carolina Zandueta, Beatriz Vera, Leire Urquiza, Luis Sierrasesúmaga, Mikel San Julián, Gemma Toledo, Juan Fueyo, Candelaria Gomez-Manzano, Wensceslao Torre, Fernando Lecanda, Ana Patiño-García, Marta M Alonso
Osteosarcoma is the most common malignant bone tumor in children and adolescents. The presence of metastases and the lack of response to conventional treatment are the major adverse prognostic factors. Therefore, there is an urgent need for new treatment strategies that overcome both of these problems. Our purpose was to elucidate whether the use of the oncolytic adenovirus Δ24-RGD alone or in combination with standard chemotherapy would be effective, in vitro and in vivo, against osteosarcoma. Our results showed that Δ24-RGD exerted a potent antitumor effect against osteosarcoma cell lines that was increased by the addition of cisplatin...
October 2014: Journal of Bone and Mineral Research