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Cardiac Health

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5 papers 25 to 100 followers
By Brooke Manor Endocrinology
Howard D Sesso, William G Christen, Vadim Bubes, Joanne P Smith, Jean MacFadyen, Miriam Schvartz, JoAnn E Manson, Robert J Glynn, Julie E Buring, J Michael Gaziano
CONTEXT: Although multivitamins are used to prevent vitamin and mineral deficiency, there is a perception that multivitamins may prevent cardiovascular disease (CVD). Observational studies have shown inconsistent associations between regular multivitamin use and CVD, with no long-term clinical trials of multivitamin use. OBJECTIVE: To determine whether long-term multivitamin supplementation decreases the risk of major cardiovascular events among men. DESIGN, SETTING, AND PARTICIPANTS: The Physicians' Health Study II, a randomized, double-blind, placebo-controlled trial of a common daily multivitamin, began in 1997 with continued treatment and follow-up through June 1, 2011...
November 7, 2012: JAMA: the Journal of the American Medical Association
Lu Wang, JoAnn E Manson, Howard D Sesso
The potential effects of inadequate or excessive calcium supply on cardiovascular disease (CVD) are receiving growing attention. We review experimental, epidemiologic, and clinical evidence regarding the role of calcium intake in the development of CVD in adults. In vitro and in vivo laboratory studies have shown that calcium may affect the risk of developing CVD through multiple mechanisms including blood cholesterol, insulin secretion and sensitivity, vasodilation, inflammatory profile, thrombosis, obesity, and vascular calcification...
April 1, 2012: American Journal of Cardiovascular Drugs: Drugs, Devices, and Other Interventions
Richard K Burt, Maria Carolina Oliveira, Sanjiv J Shah, Daniela A Moraes, Belinda Simoes, Mihai Gheorghiade, James Schroeder, Eric Ruderman, Dominique Farge, Z Jessie Chai, Zora Marjanovic, Sandeep Jain, Amy Morgan, Francesca Milanetti, Xiaoqiang Han, Borko Jovanovic, Irene B Helenowski, Julio Voltarelli
BACKGROUND: Autologous haemopoietic stem-cell transplantation (HSCT) benefits patients with systemic sclerosis but has been associated with significant treatment-related mortality and failure to improve diffusion capacity of carbon monoxide (DLCO). We aimed to assess efficacy of HSCT and use of rigorous cardiac screening in this group. METHODS: We assessed patients with diffuse systemic sclerosis or limited systemic sclerosis and interstitial lung disease who were treated with HSCT as part of a study or on a compassionate basis at Northwestern University (Chicago, IL, USA) or the University of São Paulo (Ribeirão Preto, Brazil)...
March 30, 2013: Lancet
John A Bittl
New England Journal of Medicine, Volume 0, Issue 0, Ahead of Print.
January 2, 2014: New England Journal of Medicine
Chadi A Calarge, Ginger Nicol, Janet A Schlechte, Trudy L Burns
OBJECTIVE: Second-generation antipsychotics (SGAs) cause weight gain and cardiometabolic abnormalities in children and adolescents. Less well-investigated is the outcome of these adverse events following SGA discontinuation, which we examined. METHODS: Medically healthy 7 to 17-year-old patients treated with risperidone for ≥6 months were enrolled and returned for follow-up, 1.5 years later. Treatment history was extracted from the medical and pharmacy records...
April 2014: Journal of Child and Adolescent Psychopharmacology
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