Jerzy Lasota, Małgorzata Chłopek, Maciej Kaczorowski, Klubíčková Natálie, Janusz Ryś, Janusz Kopczyński, Oksana Sulaieva, Michael Michal, Anna Kruczak, Agnieszka Harazin-Lechowska, Magdalena Szczepaniak, Olena Koshyk, Agnieszka Hałoń, Piotr Czapiewski, Zied Abdullaev, Artur Kowalik, Kenneth D Aldape, Michal Michal, Markku Miettinen
Synovial sarcoma is a relatively common soft tissue tumor characterized by highly specific t(X;18)(p11;q11) translocation resulting in the fusion of SS18 with members of SSX gene family. Typically, detection of SS18 locus rearrangement by fluorescence in situ hybridization or SS18 :: SSX fusion transcripts confirms the diagnosis. More recently, immunohistochemistry (IHC) for SS18-SSX chimeric protein (E9X9V) and C-terminus of SSX (E5A2C) showed high specificity and sensitivity for synovial sarcoma. This study screened a cohort of >1000 soft tissue and melanocytic tumors using IHC and E9X9V and E5A2C antibodies...
January 1, 2024: American Journal of Surgical Pathology