collection
https://read.qxmd.com/read/37899499/utility-of-immunohistochemistry-with-antibodies-to-ss18-ssx-chimeric-proteins-and-c-terminus-of-ssx-protein-for-synovial-sarcoma-differential-diagnosis
#1
JOURNAL ARTICLE
Jerzy Lasota, Małgorzata Chłopek, Maciej Kaczorowski, Klubíčková Natálie, Janusz Ryś, Janusz Kopczyński, Oksana Sulaieva, Michael Michal, Anna Kruczak, Agnieszka Harazin-Lechowska, Magdalena Szczepaniak, Olena Koshyk, Agnieszka Hałoń, Piotr Czapiewski, Zied Abdullaev, Artur Kowalik, Kenneth D Aldape, Michal Michal, Markku Miettinen
Synovial sarcoma is a relatively common soft tissue tumor characterized by highly specific t(X;18)(p11;q11) translocation resulting in the fusion of SS18 with members of SSX gene family. Typically, detection of SS18 locus rearrangement by fluorescence in situ hybridization or SS18 :: SSX fusion transcripts confirms the diagnosis. More recently, immunohistochemistry (IHC) for SS18-SSX chimeric protein (E9X9V) and C-terminus of SSX (E5A2C) showed high specificity and sensitivity for synovial sarcoma. This study screened a cohort of >1000 soft tissue and melanocytic tumors using IHC and E9X9V and E5A2C antibodies...
January 1, 2024: American Journal of Surgical Pathology
https://read.qxmd.com/read/32796172/the-2020-who-classification-what-s-new-in-soft-tissue-tumor-pathology
#2
REVIEW
Michael E Kallen, Jason L Hornick
The fifth edition of the World Health Organization Classification of Tumors of Soft Tissue and Bone was published in early 2020. The revisions reflect a consensus among an international expert editorial board composed of soft tissue and bone pathologists, geneticists, a medical oncologist, surgeon, and radiologist. The changes in the soft tissue tumor chapter notably include diverse, recently described tumor types (eg, atypical spindle cell/pleomorphic lipomatous tumor, angiofibroma of soft tissue, and CIC-rearranged sarcoma), new clinically significant prognostic information for a variety of existing entities (eg, dedifferentiated liposarcoma and solitary fibrous tumor), and a plethora of novel genetic alterations, some of practical diagnostic relevance (eg, NAB2-STAT6 in solitary fibrous tumor, FOSB rearrangements in epithelioid hemangioma and pseudomyogenic hemangioendothelioma, and SUZ12 or EED mutations in malignant peripheral nerve sheath tumor, leading to loss of H3K27 trimethylation)...
January 2021: American Journal of Surgical Pathology
https://read.qxmd.com/read/31802230/ewing-sarcoma-and-ewing-like-tumors
#3
REVIEW
Marta Sbaraglia, Alberto Righi, Marco Gambarotti, Angelo P Dei Tos
Ewing sarcoma (ES) and Ewing-like sarcomas are highly aggressive round cell mesenchymal neoplasms, most often occurring in children and young adults. The identification of novel molecular alterations has greatly contributed to a profound reappraisal of classification, to the extent that the category of undifferentiated round cell sarcoma has significantly shrunk. In fact, in addition to Ewing sarcoma, we currently recognize three main categories: round cell sarcomas with EWSR1 gene fusion with non-ETS family members, CIC-rearranged sarcomas, and BCOR-rearranged sarcomas...
January 2020: Virchows Archiv: An International Journal of Pathology
https://read.qxmd.com/read/31471922/atypical-lipomatous-tumour-well-differentiated-liposarcoma-and-de-differentiated-liposarcoma-in-patients-aged%C3%A2-%C3%A2-%C3%A2-40%C3%A2-years-a-study-of-116-patients
#4
JOURNAL ARTICLE
Rebecca Waters, Andrew Horvai, Patricia Greipp, Ivy John, Elizabeth G Demicco, Brendan C Dickson, Munir R Tanas, Brandon T Larsen, Nasir Ud Din, David H Creytens, Armita Bahrami, Leona A Doyle, Vickie Y Jo, Alyaa Al-Ibraheemi, Khin Thway, Sarah M Jenkins, Brittany Siontis, Andrew Folpe, Karen Fritchie
AIMS: Limited data exist on atypical lipomatous tumour (ALT)/well-differentiated liposarcoma (WDL) and de-differentiated liposarcoma (DDLPS) in children and young adults. METHODS AND RESULTS: Cases of ALT/WDL/DDLPS arising in patients aged ≤ 40 years were collected from multiple institutional and consultation archives. A total of 116 cases of ALT/WDL (75) and DDLPS (41) were identified, representing fewer than 5% of these tumours seen at our institutions during this time-period...
December 2019: Histopathology
https://read.qxmd.com/read/31436108/undifferentiated-pleomorphic-sarcoma-with-emperipolesis
#5
JOURNAL ARTICLE
Charisse Liz Baste, Steven Garzon, Suman Setty
No abstract text is available yet for this article.
May 2020: International Journal of Surgical Pathology
https://read.qxmd.com/read/31175328/histone-h3k27-dimethyl-loss-is-highly-specific-for-malignant-peripheral-nerve-sheath-tumor-and-distinguishes-true-prc2-loss-from-isolated-h3k27-trimethyl-loss
#6
JOURNAL ARTICLE
Dylan M Marchione, Amanda Lisby, Angela N Viaene, Mariarita Santi, MacLean Nasrallah, Li-Ping Wang, Erik A Williams, Ana B Larque, Ivan Chebib, Benjamin A Garcia, John B Wojcik
Malignant peripheral nerve sheath tumors contain loss of histone H3K27 trimethylation (H3K27me3) due to driver mutations affecting the polycomb repressive complex 2 (PRC2). Consequently, loss of H3K27me3 staining has served as a diagnostic marker for this tumor type. However, recent reports demonstrate H3K27me3 loss in numerous other tumors, including some in the differential diagnosis of malignant peripheral nerve sheath tumor. Since these tumors lose H3K27me3 through mechanisms distinct from PRC2 loss, we set out to determine whether loss of dimethylation of H3K27, which is also catalyzed by PRC2, might be a more specific marker of PRC2 loss and malignant peripheral nerve sheath tumor...
October 2019: Modern Pathology
https://read.qxmd.com/read/31053757/surgical-resection-margin-classifications-for-high-grade-pleomorphic-soft-tissue-sarcomas-of-the-extremity-or-trunk-definitions-of-adequate-resection-margins-and-recommendations-for-sampling-margins-from-primary-resection-specimens
#7
JOURNAL ARTICLE
Margaret M Cates, Justin M M Cates
Adequacy of surgical resection margins for soft tissue sarcomas are poorly defined because of the various classifications and definitions used in prior studies of heterogeneous patient cohorts and inconsistent margin sampling protocols. Surgical resection margins of 166 primary, high-grade, pleomorphic sarcomas of the extremity or trunk were classified according to American Joint Committee on Cancer R and Musculoskeletal Tumor Society categories, as well as by metric distance and tissue composition. None of the cases were treated with neoadjuvant therapy...
October 2019: Modern Pathology
https://read.qxmd.com/read/31106439/ntrk-rearranged-mesenchymal-tumour-in-a-3-year-old-female-a-diagnostic-quandary
#8
JOURNAL ARTICLE
Mikako Warren, Dean Anselmo, Moe Takeda, Nick Shillingford, Matthew C Hiemenz, Rachana Shah
No abstract text is available yet for this article.
November 2019: Histopathology
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