Yao-Wen Cheng, Emmalee Phelps, Vincent Ganapini, Noor Khan, Fangqian Ouyang, Huiping Xu, Sahil Khanna, Raseen Tariq, Rachel J Friedman-Moraco, Michael H Woodworth, Tanvi Dhere, Colleen S Kraft, Dina Kao, Justin Smith, Lien Le, Najwa El-Nachef, Nirmal Kaur, Sree Kowsika, Adam Ehrlich, Michael Smith, Nasia Safdar, Elizabeth Ann Misch, Jessica R Allegretti, Ann Flynn, Zain Kassam, Asif Sharfuddin, Raj Vuppalanchi, Monika Fischer
Fecal microbiota transplant (FMT) is recommended for Clostridium difficile infection (CDI) treatment; however, use in solid organ transplantation (SOT) patients has theoretical safety concerns. This multicenter, retrospective study evaluated FMT safety, effectiveness, and risk factors for failure in SOT patients. Primary cure and overall cure were defined as resolution of diarrhea or negative C difficile stool test after a single FMT or after subsequent FMT(s) ± anti-CDI antibiotics, respectively...
February 2019: American Journal of Transplantation