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JOURNAL ARTICLE
Le-Ben Wan, Cara F Levitch, Andrew M Perez, Jess W Brallier, Dan V Iosifescu, Lee C Chang, Alexandra Foulkes, Sanjay J Mathew, Dennis S Charney, James W Murrough
OBJECTIVE: Ketamine has demonstrated rapid antidepressant effects in patients with treatment-resistant depression (TRD); however, the safety and tolerability of ketamine in this population have not been fully described. Herein we report the largest study to date of the safety, tolerability, and acceptability of ketamine in TRD. METHOD: Data from 205 intravenous (IV) ketamine infusions (0.5 mg/kg over 40 minutes) in 97 participants with DSM-IV-defined major depressive disorder (MDD) were pooled from 3 clinical trials conducted between 2006 and 2012 at 2 academic medical centers...
March 2015: Journal of Clinical Psychiatry
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JOURNAL ARTICLE
Carrie Arnold
No abstract text is available yet for this article.
October 2013: Lancet Neurology
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