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RANDOMIZED CONTROLLED TRIAL
Jean-Pierre Frat, Arnaud W Thille, Alain Mercat, Christophe Girault, Stéphanie Ragot, Sébastien Perbet, Gwénael Prat, Thierry Boulain, Elise Morawiec, Alice Cottereau, Jérôme Devaquet, Saad Nseir, Keyvan Razazi, Jean-Paul Mira, Laurent Argaud, Jean-Charles Chakarian, Jean-Damien Ricard, Xavier Wittebole, Stéphanie Chevalier, Alexandre Herbland, Muriel Fartoukh, Jean-Michel Constantin, Jean-Marie Tonnelier, Marc Pierrot, Armelle Mathonnet, Gaëtan Béduneau, Céline Delétage-Métreau, Jean-Christophe M Richard, Laurent Brochard, René Robert
BACKGROUND: Whether noninvasive ventilation should be administered in patients with acute hypoxemic respiratory failure is debated. Therapy with high-flow oxygen through a nasal cannula may offer an alternative in patients with hypoxemia. METHODS: We performed a multicenter, open-label trial in which we randomly assigned patients without hypercapnia who had acute hypoxemic respiratory failure and a ratio of the partial pressure of arterial oxygen to the fraction of inspired oxygen of 300 mm Hg or less to high-flow oxygen therapy, standard oxygen therapy delivered through a face mask, or noninvasive positive-pressure ventilation...
June 4, 2015: New England Journal of Medicine
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RANDOMIZED CONTROLLED TRIAL
François Stéphan, Benoit Barrucand, Pascal Petit, Saida Rézaiguia-Delclaux, Anne Médard, Bertrand Delannoy, Bernard Cosserant, Guillaume Flicoteaux, Audrey Imbert, Catherine Pilorge, Laurence Bérard
IMPORTANCE: Noninvasive ventilation delivered as bilevel positive airway pressure (BiPAP) is often used to avoid reintubation and improve outcomes of patients with hypoxemia after cardiothoracic surgery. High-flow nasal oxygen therapy is increasingly used to improve oxygenation because of its ease of implementation, tolerance, and clinical effectiveness. OBJECTIVE: To determine whether high-flow nasal oxygen therapy was not inferior to BiPAP for preventing or resolving acute respiratory failure after cardiothoracic surgery...
June 16, 2015: JAMA
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JOURNAL ARTICLE
Steve G Peters, Steven R Holets, Peter C Gay
BACKGROUND: Patients with do-not-intubate (DNI) status and respiratory failure are commonly treated with noninvasive ventilation (NIV). High-flow nasal cannula (HFNC) therapy supplies a high flow of heated and humidified oxygen that may provide an effective alternative to NIV. We assessed the efficacy of HFNC in DNI patients with hypoxemic respiratory distress. METHODS: We identified 50 DNI patients with hypoxemic respiratory distress who were admitted to a medical ICU and who received HFNC...
April 2013: Respiratory Care
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RANDOMIZED CONTROLLED TRIAL
Salvatore Maurizio Maggiore, Francesco Antonio Idone, Rosanna Vaschetto, Rossano Festa, Andrea Cataldo, Federica Antonicelli, Luca Montini, Andrea De Gaetano, Paolo Navalesi, Massimo Antonelli
RATIONALE: Oxygen is commonly administered after extubation. Although several devices are available, data about their clinical efficacy are scarce. OBJECTIVES: To compare the effects of the Venturi mask and the nasal high-flow (NHF) therapy on PaO2/FiO2SET ratio after extubation. Secondary endpoints were to assess effects on patient discomfort, adverse events, and clinical outcomes. METHODS: Randomized, controlled, open-label trial on 105 patients with a PaO2/FiO2 ratio less than or equal to 300 immediately before extubation...
August 1, 2014: American Journal of Respiratory and Critical Care Medicine
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EDITORIAL
Raffaele Scala
No abstract text is available yet for this article.
April 2014: Respiratory Care
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