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RIFLE Classification

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By Isabel Acosta-Ochoa Nephrology senior staff. Valladolid. Spain
Eun Ju Lee, Ha Nee Jang, Hyun Seop Cho, Eunjin Bae, Tae Won Lee, Se-Ho Chang, Dong Jun Park
Intravenous (IV) acyclovir is commonly administered medication for viral infection but is well known for its nephrotoxicity. However, there was no study for incidence, risk factors, and clinical outcomes of acute kidney injury (AKI) associated with IV acyclovir administration. We retrospectively reviewed the medical records of 287 patients who were medicated IV acyclovir from January 2008 to May 2013 in Gyeongsang National University Hospital. All had documented medical histories and underwent medical review...
November 2018: Renal Failure
Jader Pereira Almeida, Ivan Ferraz Valente, Marina da Rocha Lordelo
OBJECTIVE: To evaluate the association between acute kidney injury through the pediatric Risk, Injury, Failure, Loss and End Stage Renal Disease score and mortality in a pediatric intensive care unit. METHODS: This retrospective cohort study assessed all children admitted to the pediatric intensive care unit of a reference hospital in Brazil from January to December 2016. Patients were screened for the presence of acute kidney injury through the pediatric Risk, Injury, Failure, Loss and End Stage Renal Disease score...
October 2018: Revista Brasileira de Terapia Intensiva
Kátia M Wahrhaftig, Luis C L Correia, Denise Matias, Carlos A M De Souza
Introduction. The RIFLE classification defines three severity criteria for acute kidney injury (AKI): risk, injury, and failure. It was associated with mortality according to the gradation of AKI severity. However, it is not known if the APACHE II score, associated with the RIFLE classification, results in greater discriminatory power in relation to mortality in critical patients. Objective. To analyze whether the RIFLE classification adds value to the performance of APACHE II in predicting mortality in critically ill patients...
2013: International Journal of Nephrology
Ayako Shiba, Shigehiko Uchino, Tomoko Fujii, Masanori Takinami, Shoichi Uezono
BACKGROUND: Acute kidney injury (AKI) occurs in 6.1%-22.4% of patients undergoing major noncardiac surgery. Previous studies have shown no association between intraoperative urine output and postoperative acute renal failure. However, these studies used various definitions of acute renal failure. We therefore investigated the association between intraoperative oliguria and postoperative AKI defined by the serum creatinine criteria of the Risk, Injury, Failure, Loss, and End-stage kidney disease (RIFLE) classification...
November 2018: Anesthesia and Analgesia
Jorge Ruiz-Criado, Maria-Angeles Ramos-Barron, Gema Fernandez-Fresnedo, Emilio Rodrigo, Angel-Luis Martin De Francisco, Manuel Arias, Carlos Gomez-Alamillo
BACKGROUND: Epidemiological studies of acute kidney injury (AKI) have focused on patients admitted to intensive care units (ICUs), and several have studied hospitalized non-ICU patients, but analysis of patients referred to Nephrology is sparse. We analyzed factors associated with short- and long-term morbimortality among hospitalized non-ICU patients with AKI who were referred to Nephrology. METHODS: A retrospective study with data prospectively collected from 170 non-ICU patients, with referral to the Nephrology Unit, recruited over a 4-year period, was performed...
2015: Nephron
Marc-Gilbert Lagny, François Jouret, Jean-Noël Koch, Francine Blaffart, Anne-Françoise Donneau, Adelin Albert, Laurence Roediger, Jean-Marie Krzesinski, Jean-Olivier Defraigne
BACKGROUND: Adult cardiac surgery is significantly associated with the development of acute kidney injury (AKI). Still, the incidence and outcomes of AKI vary according to its definition. Our retrospective monocentric study comparatively investigates the yield of RIFLE definition, which is based on the elevation of serum creatinine levels (SCr) or the reduction of urine output (UO), taking into account only one or both criteria. Pre- and per-operative risk factors for post-operative AKI were evaluated...
May 30, 2015: BMC Nephrology
Rogerio da Hora Passos, Joao Gabriel Rosa Ramos, André Gobatto, Juliana Caldas, Etienne Macedo, Paulo Benigno Batista
BACKGROUND: In evidence-based medicine, multicenter, prospective, randomized controlled trials (RCTs) are the gold standard for evaluating treatment benefits and ensuring the effectiveness of interventions. Patient-centered outcomes, such as mortality, are most often the preferred evaluated outcomes. While there is currently agreement on how to classify renal dysfunction in critically ill patients , the application frequency of this new classification system in RCTs has not previously been evaluated...
April 24, 2018: Critical Care: the Official Journal of the Critical Care Forum
Elias Hellou, Zaher Bahouth, Edmond Sabo, Zaid Abassi, Ofer Nativ
Background: The aim of this study was to report the impact of patients' baseline characteristics on the incidence of acute kidney injury (AKI) after nephron-sparing surgery (NSS) for localized kidney cancer. Patients and methods: Data from our kidney cancer database were retrospectively extracted to include 402 patients who underwent NSS between March 2000 and June 2016, and had sufficient data. Definition of AKI was based on the postoperative serum creatinine levels and estimated glomerular filtration rate (eGFR) magnitude, which were measured during the 72 h after surgery...
March 2018: Therapeutic Advances in Urology
Flávio Teles de Farias Filho, Maria Carolina Santos Malafaia, Erika Thaynara Martins
In recent years, the diagnosis of acute kidney injury (AKI) has been based on classifications such as RIFLE, AKIN and KDIGO, which has the goal of world standardization and timely recognition of the disease. It is essential that intensivists be aware about these classifications, because most of the time, they will have the first opportunity to diagnose AKI. However, it is still very common that the nephrologist consultation be performed in advanced stages of the AKI, when the interventions to halt the progression are very limited...
March 2017: Jornal Brasileiro de Nefrologia: ʹorgão Oficial de Sociedades Brasileira e Latino-Americana de Nefrologia
Itir Yegenaga, Fatih Kamis, Canan Baydemir, Elizade Erdem, Koray Celebi, Necmi Eren, Nur Baykara
Aims The prevention of acute kidney injury can be lifesaving for the intensive care unit patients. However, conventional methods are not sufficient for the prediction of the risk of future acute kidney injury. In this study, the promising biomarker, neutrophil gelatinase-associated lipocalin, was compared with cystatin C as an indicator for the risk of future acute kidney injury. Methods One hundred and eighty-three adult patients without chronic kidney disease or renal replacement therapy were included in this study...
March 2018: Annals of Clinical Biochemistry
F Kork, F Balzer, A Krannich, M H Bernardi, H K Eltzschig, J Jankowski, C Spies
AIM: Acute kidney injury (AKI) is diagnosed by a 50% increase in creatinine. For patients without a baseline creatinine measurement, guidelines suggest estimating baseline creatinine by back-calculation. The aim of this study was to evaluate different glomerular filtration rate (GFR) equations and different GFR assumptions for back-calculating baseline creatinine as well as the effect on the diagnosis of AKI. METHODS: The Modification of Diet in Renal Disease, the Chronic Kidney Disease Epidemiology (CKD-EPI) and the Mayo quadratic (MQ) equation were evaluated to estimate baseline creatinine, each under the assumption of either a fixed GFR of 75 mL min-1  1...
March 2017: Acta Physiologica
Leila C Volpon, Edward K Sugo, Julio C Consulin, Tabata L G Tavares, Davi C Aragon, Ana P C P Carlotti
OBJECTIVE: We aimed to investigate the epidemiology, risk factors, and short- and medium-term outcome of acute kidney injury classified according to pediatric Risk, Injury, Failure, Loss, End-Stage Renal Disease, and Kidney Disease: Improving Global Outcomes criteria in critically ill children. DESIGN: Prospective observational cohort study. SETTING: Two eight-bed PICUs of a tertiary-care university hospital. PATIENTS: A heterogeneous population of critically ill children...
May 2016: Pediatric Critical Care Medicine
Jiachuan Xiong, Xi Tang, Zhangxue Hu, Ling Nie, Yiqin Wang, Jinghong Zhao
The sensitivity and accuracy of the Risk/Injury/Failure/Loss/End-stage (RIFLE) versus acute kidney injury Network (AKIN) criteria for acute kidney injury (AKI) in critically ill patients remains uncertain. Therefore, we performed a systematic review and meta-analysis to investigate the incidence and prognostic value of the RIFLE versus AKIN criteria for AKI in critically ill patients. Literatures were identified by searching Medline, Embase, PubMed, and China National Knowledge Infrastructure (CNKI) database...
December 7, 2015: Scientific Reports
Min Ji Shin, Harin Rhee, Il Young Kim, Sang Heon Song, Dong Won Lee, Soo Bong Lee, Ihm Soo Kwak, Eun Young Seong
BACKGROUND: The RIFLE classification is widely used to assess the severity of acute kidney injury (AKI), but its application to geriatric AKI patients complicated by medical problems has not been reported. METHODS: We investigated 256 geriatric patients (≥65 years old; mean age, 74.4 ± 6.3 years) who developed AKI in the intensive care unit (ICU) according to the RIFLE classification. Etiologic, clinical, and prognostic variables were analyzed. RESULTS: They were categorized into RIFLE-R (n = 53), RIFLE-I (n = 102), and RIFLE-F (n = 101) groups...
June 2016: Clinical and Experimental Nephrology
Edward D Siew, Michael E Matheny
BACKGROUND/AIMS: The study of acute kidney injury (AKI) has expanded with the increasing availability of electronic health records and the use of standardized definitions. Understanding the impact of AKI between settings is limited by heterogeneity in the selection of reference creatinine to anchor the definition of AKI. In this mini-review, we discuss different approaches used to select reference creatinine and their relative merits and limitations. METHODS: We reviewed the literature to obtain representative examples of published baseline creatinine definitions when pre-hospital data were not available, as well as literature evaluating the estimation of baseline renal function, using PubMed and reference back-tracing within known works...
2015: Nephron
Edward Koifman, Amit Segev, Paul Fefer, Israel Barbash, Avi Sabbag, Diego Medvedovsky, Dan Spiegelstein, Ashraf Hamdan, Ilan Hay, Ehud Raanani, Ilan Goldenberg, Victor Guetta
BACKGROUND: Acute kidney injury (AKI) was demonstrated to adversely affect outcome in patients undergoing transcatheter aortic valve implantation (TAVI). We compared predictors for AKI and associated outcomes according to various definitions among patients undergoing TAVI in a tertiary medical center. METHODS: Two-hundred and seventeen TAVI patients were evaluated for the occurrence of AKI according to Kidney Disease Improving Global Outcomes (KDIGO)/Valve Academic Research Consortium (VARC-2) and Risk Injury Failure Loss End-Stage (RIFLE) definitions...
February 15, 2016: Catheterization and Cardiovascular Interventions
Sukru Ulusoy, Derya Arı, Gulsum Ozkan, Muammer Cansız, Kubra Kaynar
Acute kidney injury (AKI) is a major cause of mortality and morbidity in hospitalized patients. Incidence and mortality rates vary from country to country, and according to different in-hospital monitoring units and definitions of AKI. The aim of this study was to determine factors affecting frequency of AKI and mortality in our hospital. We retrospectively evaluated data for 1550 patients diagnosed with AKI and 788 patients meeting the Kidney Disease: Improving Global Outcomes (KDIGO) guideline AKI criteria out of a total of 174 852 patients hospitalized in our institution between January 1, 2007 and December 31, 2012...
July 2015: Artificial Organs
Myoung Hwa Kim, Shin Ok Koh, Eun Jung Kim, Jin Sun Cho, Sung-Won Na
BACKGROUND: Contrast medium used for radiologic tests can decrease renal function. However there have been few studies on contrast-associated acute kidney injury in intensive care unit (ICU) patients. The objective of this study was to evaluate the incidence, characteristics, and outcome of contrast-associated acute kidney injury (CA-AKI) patients using the Risk, Injury, Failure, Loss, and End-stage kidney disease (RIFLE) criteria in critically ill patients in the ICU. METHODS: We conducted a retrospective study of adult patients who underwent contrast-enhanced radiologic tests from January 2011 to December 2012 in a 30-bed medical ICU and a 24-bed surgical ICU...
2015: BMC Anesthesiology
Steve K Harris, Andrew J P Lewington, David A Harrison, Kathy M Rowan
We report the stepwise application of the RIFLE classification in 155,624 admissions in the UK Intensive Care National Audit & Research Centre Case Mix Programme database. The assumptions required to define RIFLE and their relationship with renal replacement therapy (RRT) and ICU mortality were assessed. Previous reports had not explored the method of estimating baseline creatinine, the position of class boundaries, or interactions between urine volume (AKI-U) and the peak/estimated baseline creatinine (AKI-Cr) within 24 h of ICU admission...
August 2015: Kidney International
Zhilian Li, Lu Cai, Xinling Liang, Zhiming Du, Yuanhan Chen, Shengli An, Ning Tan, Lixia Xu, Ruizhao Li, Liwen Li, Wei Shi
OBJECTIVE: Acute kidney injury (AKI) in patients hospitalized for acute heart failure (AHF) is usually type 1 of the cardiorenal syndrome (CRS) and has been associated with increased morbidity and mortality. Early recognition of AKI is critical. This study was to determine if the new KDIGO criteria (Kidney Disease: Improving Global Outcomes) for identification and short-term prognosis of early CRS type 1 was superior to the previous RIFLE and AKIN criteria. METHODS: The association between AKI diagnosed by KDIGO but not by RIFLE or AKIN and in-hospital mortality was retrospectively evaluated in 1005 Chinese adult patients with AHF between July 2008 and May 2012...
2014: PloS One
2014-12-31 17:45:20
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