Andreas Holbro, Thomas Lehmann, Sabine Girsberger, Martin Stern, Franco Gambazzi, Didier Lardinois, Dominik Heim, Jakob R Passweg, André Tichelli, Lukas Bubendorf, Spasenija Savic, Katrin Hostettler, Peter Grendelmeier, Joerg P Halter, Michael Tamm
Bronchiolitis obliterans (BO) is a severe complication after allogeneic hematopoietic stem cell transplantation with an unfavorable prognosis. Lung biopsy remains the gold standard for diagnosis. In this retrospective single-center study, we describe 33 patients who underwent biopsy for suspected BO. Ten patients had constrictive BO (CBO); 9 had lymphocytic bronchiolitis (LB), characterized by lymphocytic infiltration of the bronchioles. Six additional patients (4, CBO; 2, LB) had concomitant infection; 8 had other pathological diagnoses...
June 2013: Biology of Blood and Marrow Transplantation