Sharon A Chung, Elizabeth E Brown, Adrienne H Williams, Paula S Ramos, Celine C Berthier, Tushar Bhangale, Marta E Alarcon-Riquelme, Timothy W Behrens, Lindsey A Criswell, Deborah Cunninghame Graham, F Yesim Demirci, Jeffrey C Edberg, Patrick M Gaffney, John B Harley, Chaim O Jacob, M Ilyas Kamboh, Jennifer A Kelly, Susan Manzi, Kathy L Moser-Sivils, Laurie P Russell, Michelle Petri, Betty P Tsao, Tim J Vyse, Raphael Zidovetzki, Matthias Kretzler, Robert P Kimberly, Barry I Freedman, Robert R Graham, Carl D Langefeld
Lupus nephritis is a manifestation of SLE resulting from glomerular immune complex deposition and inflammation. Lupus nephritis demonstrates familial aggregation and accounts for significant morbidity and mortality. We completed a meta-analysis of three genome-wide association studies of SLE to identify lupus nephritis-predisposing loci. Through genotyping and imputation, >1.6 million markers were assessed in 2000 unrelated women of European descent with SLE (588 patients with lupus nephritis and 1412 patients with lupus without nephritis)...
December 2014: Journal of the American Society of Nephrology: JASN