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RANDOMIZED CONTROLLED TRIAL
John R Geddes, Guy M Goodwin, Jennifer Rendell, Jean-Michel Azorin, Andrea Cipriani, Michael J Ostacher, Richard Morriss, Nicola Alder, Ed Juszczak
BACKGROUND: Lithium carbonate and valproate semisodium are both recommended as monotherapy for prevention of relapse in bipolar disorder, but are not individually fully effective in many patients. If combination therapy with both agents is better than monotherapy, many relapses and consequent disability could be avoided. We aimed to establish whether lithium plus valproate was better than monotherapy with either drug alone for relapse prevention in bipolar I disorder. METHODS: 330 patients aged 16 years and older with bipolar I disorder from 41 sites in the UK, France, USA, and Italy were randomly allocated to open-label lithium monotherapy (plasma concentration 0...
January 30, 2010: Lancet
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