Evelien A N Oostdijk, Jozef Kesecioglu, Marcus J Schultz, Caroline E Visser, Evert de Jonge, Einar H R van Essen, Alexandra T Bernards, Ilse Purmer, Roland Brimicombe, Dennis Bergmans, Frank van Tiel, Frank H Bosch, Ellen Mascini, Arjanne van Griethuysen, Alexander Bindels, Arjan Jansz, Fred A L van Steveninck, Wil C van der Zwet, Jan Willem Fijen, Steven Thijsen, Remko de Jong, Joke Oudbier, Adrienne Raben, Eric van der Vorm, Mirelle Koeman, Philip Rothbarth, Annemieke Rijkeboer, Paul Gruteke, Helga Hart-Sweet, Paul Peerbooms, Lex J Winsser, Anne-Marie W van Elsacker-Niele, Kees Demmendaal, Afke Brandenburg, Anne Marie G A de Smet, Marc J M Bonten
IMPORTANCE: Selective decontamination of the digestive tract (SDD) and selective oropharyngeal decontamination (SOD) are prophylactic antibiotic regimens used in intensive care units (ICUs) and associated with improved patient outcome. Controversy exists regarding the relative effects of both measures on patient outcome and antibiotic resistance. OBJECTIVE: To compare the effects of SDD and SOD, applied as unit-wide interventions, on antibiotic resistance and patient outcome...
October 8, 2014: JAMA