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Antimicrobial Resistance

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13 papers 25 to 100 followers Interesting stuff in AMR
Guillermo V Sanchez, Rebecca M Roberts, Alison P Albert, Darcia D Johnson, Lauri A Hicks
Appropriate selection of antibiotic drugs is critical to optimize treatment of infections and limit the spread of antibiotic resistance. To better inform public health efforts to improve prescribing of antibiotic drugs, we conducted in-depth interviews with 36 primary care providers in the United States (physicians, nurse practitioners, and physician assistants) to explore knowledge, attitudes, and self-reported practices regarding antibiotic drug resistance and antibiotic drug selection for common infections...
December 2014: Emerging Infectious Diseases
Aaron M Milstone
No abstract text is available yet for this article.
November 2014: JAMA Pediatrics
Alison E Mather, Louise Matthews, Dominic J Mellor, Richard Reeve, Matthew J Denwood, Patrick Boerlin, Richard J Reid-Smith, Derek J Brown, John E Coia, Lynda M Browning, Daniel T Haydon, Stuart W J Reid
We examined long-term surveillance data on antimicrobial resistance (AMR) in Salmonella Typhimurium DT104 (DT104) isolates from concurrently sampled and sympatric human and animal populations in Scotland. Using novel ecological and epidemiological approaches to examine diversity, and phenotypic and temporal relatedness of the resistance profiles, we assessed the more probable source of resistance of these two populations. The ecological diversity of AMR phenotypes was significantly greater in human isolates than in animal isolates, at the resolution of both sample and population...
April 22, 2012: Proceedings. Biological Sciences
Rita L Finley, Peter Collignon, D G Joakim Larsson, Scott A McEwen, Xian-Zhi Li, William H Gaze, Richard Reid-Smith, Mohammed Timinouni, David W Graham, Edward Topp
Antibiotic resistance and associated genes are ubiquitous and ancient, with most genes that encode resistance in human pathogens having originated in bacteria from the natural environment (eg, β-lactamases and fluoroquinolones resistance genes, such as qnr). The rapid evolution and spread of "new" antibiotic resistance genes has been enhanced by modern human activity and its influence on the environmental resistome. This highlights the importance of including the role of the environmental vectors, such as bacterial genetic diversity within soil and water, in resistance risk management...
September 2013: Clinical Infectious Diseases: An Official Publication of the Infectious Diseases Society of America
Min Tao Wan, Chin Cheng Chou
Methicillin-resistant Staphylococcus aureus (MRSA) is a potential zoonotic agent. Municipal wastewater treatment plants (WWTPs) can be reservoirs for MRSA dissemination. It is unclear, however, whether MRSA and its β-lactam resistance gene (mecA) can be spread from WWTPs that treat the wastewater of swine auction markets. The aims of the study were to compare (1) the abundance of the mecA gene in one municipal (M-) and one swine (S-) WWTP and (2) the genotypic and phenotypic characteristics of MRSA isolates from these two types of WWTPs...
November 1, 2014: Water Research
Brad Spellberg, John G Bartlett, David N Gilbert
In its recent annual report on global risks, the World Economic Forum (WEF) concluded that "arguably the greatest risk . . . to human health comes in the form of antibiotic-resistant bacteria. We live in a bacterial world where we will never be able to stay ahead of the mutation curve. A test of..
January 24, 2013: New England Journal of Medicine
(no author information available yet)
No abstract text is available yet for this article.
April 5, 2014: Veterinary Record
(no author information available yet)
No abstract text is available yet for this article.
April 5, 2014: Veterinary Record
Dustin D Flannery, Sanjeev Swami, Shannon Chan, Stephen Eppes
Antimicrobial stewardship programs (ASPs) can help improve antimicrobial use in hospitals and, therefore, reduce resistance. Our hospital implemented an ASP in 2004, with interventions based on Infectious Diseases Society of America recommendations. We aimed to assess the perceived effectiveness of ASP interventions on antimicrobial prescribing behavior by surveying hospital-based providers at a pediatric tertiary care center. We surveyed providers via an online survey utilizing questions with a Likert scale response format...
July 2014: Clinical Pediatrics
Anthony S Fauci, lary D Marston
No abstract text is available yet for this article.
May 14, 2014: JAMA: the Journal of the American Medical Association
Dagmar Chudobova, Simona Dostalova, Iva Blazkova, Petr Michalek, Branislav Ruttkay-Nedecky, Matej Sklenar, Lukas Nejdl, Jiri Kudr, Jaromir Gumulec, Katerina Tmejova, Marie Konecna, Marketa Vaculovicova, David Hynek, Michal Masarik, Jindrich Kynicky, Rene Kizek, Vojtech Adam
There is an arising and concerning issue in the field of bacterial resistance, which is confirmed by the number of deaths associated with drug-resistant bacterial infections. The aim of this study was to compare the effects of antibiotics on Staphylococcus aureus non-resistant strain and strains resistant to cadmium or lead ions. Metal resistant strains were created by the gradual addition of 2 mM solution of metal ions (cadmium or lead) to the S. aureus culture. An increasing antimicrobial effect of ampicillin, streptomycin, penicillin and tetracycline (0, 10, 25, 50, 75, 150, 225 and 300 µM) on the resistant strains was observed using a method of growth curves...
March 2014: International Journal of Environmental Research and Public Health
Sarala Malla, Shyam Prakash Dumre, Geeta Shakya, Palpasa Kansakar, Bhupraj Rai, Anowar Hossain, Gopinath Balakrish Nair, M John Albert, David Sack, Stephen Baker, Motiur Rahman
BACKGROUND: Antimicrobial resistance (AMR) is a major global public health concern and its surveillance is a fundamental tool for monitoring the development of AMR. In 1998, the Nepalese Ministry of Health (MOH) launched an Infectious Disease (ID) programme. The key components of the programme were to establish a surveillance programme for AMR and to develop awareness among physicians regarding AMR and rational drug usage in Nepal. METHODS: An AMR surveillance programme was established and implemented by the Nepalese MOH in partnership with the International Centre for Diarrhoeal Disease Research, Bangladesh (ICDDR, B) from 1998 to 2003...
March 21, 2014: BMC Public Health
John F Prescott
Modern medicine is built on antibiotics. Antibiotics are something that we take for granted. We have however spent over 60 years educating bacteria to become resistant, and the global resistance tsunami has caught everyone unawares. Since bacteria have changed, we also have to change, and to change most of the practices of how we use antibiotics. Because the development of new antibiotics is so expensive, a stewardship approach may help to preserve those that we have now while we work to develop new antibiotics and to develop other approaches to controlling and treating infections...
July 16, 2014: Veterinary Microbiology
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