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JOURNAL ARTICLE
Brain scans from 21,297 individuals reveal the genetic architecture of hippocampal subfield volumes.
Dennis van der Meer, Jaroslav Rokicki, Tobias Kaufmann, Aldo Córdova-Palomera, Torgeir Moberget, Dag Alnæs, Francesco Bettella, Oleksandr Frei, Nhat Trung Doan, Ida E Sønderby, Olav B Smeland, Ingrid Agartz, Alessandro Bertolino, Janita Bralten, Christine L Brandt, Jan K Buitelaar, Srdjan Djurovic, Marjolein van Donkelaar, Erlend S Dørum, Thomas Espeseth, Stephen V Faraone, Guillén Fernández, Simon E Fisher, Barbara Franke, Beathe Haatveit, Catharina A Hartman, Pieter J Hoekstra, Asta K Håberg, Erik G Jönsson, Knut K Kolskår, Stephanie Le Hellard, Martina J Lund, Astri J Lundervold, Arvid Lundervold, Ingrid Melle, Jennifer Monereo Sánchez, Linn C Norbom, Jan E Nordvik, Lars Nyberg, Jaap Oosterlaan, Marco Papalino, Andreas Papassotiropoulos, Giulio Pergola, Dominique J F de Quervain, Geneviève Richard, Anne-Marthe Sanders, Pierluigi Selvaggi, Elena Shumskaya, Vidar M Steen, Siren Tønnesen, Kristine M Ulrichsen, Marcel P Zwiers, Ole A Andreassen, Lars T Westlye
The hippocampus is a heterogeneous structure, comprising histologically distinguishable subfields. These subfields are differentially involved in memory consolidation, spatial navigation and pattern separation, complex functions often impaired in individuals with brain disorders characterized by reduced hippocampal volume, including Alzheimer's disease (AD) and schizophrenia. Given the structural and functional heterogeneity of the hippocampal formation, we sought to characterize the subfields' genetic architecture...
October 2, 2018: Molecular Psychiatry
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