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RANDOMIZED CONTROLLED TRIAL
Armand Mekontso Dessap, Ferran Roche-Campo, Achille Kouatchet, Vinko Tomicic, Gaetan Beduneau, Romain Sonneville, Belen Cabello, Samir Jaber, Elie Azoulay, Diego Castanares-Zapatero, Jerome Devaquet, François Lellouche, Sandrine Katsahian, Laurent Brochard
RATIONALE: Difficult weaning from mechanical ventilation is often associated with fluid overload. B-type natriuretic peptide (BNP) has been proposed as a tool for predicting and detecting weaning failure of cardiovascular origin. OBJECTIVES: To investigate whether fluid management guided by daily BNP plasma concentrations improves weaning outcomes compared with empirical therapy dictated by clinical acumen. METHODS: In a randomized controlled multicenter study, we allocated 304 patients to either a BNP-driven or physician-driven strategy of fluid management during ventilator weaning...
December 15, 2012: American Journal of Respiratory and Critical Care Medicine
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RANDOMIZED CONTROLLED TRIAL
Armand Mekontso Dessap, Sandrine Katsahian, Ferran Roche-Campo, Hugo Varet, Achille Kouatchet, Vinko Tomicic, Gaetan Beduneau, Romain Sonneville, Samir Jaber, Michael Darmon, Diego Castanares-Zapatero, Laurent Brochard, Christian Brun-Buisson
BACKGROUND: Pulmonary edema may alter alveolar bacterial clearance and infectivity. Manipulation of fluid balance aimed at reducing fluid overload may, therefore, influence ventilator-associated pneumonia (VAP) occurrence in intubated patients. The objective of the present study was to assess the impact of a depletive fluid-management strategy on ventilator-associated complication (VAC) and VAP occurrence during weaning from mechanical ventilation. METHODS: We used data from the B-type Natriuretic Peptide for the Fluid Management of Weaning (BMW) randomized controlled trial performed in nine ICUs across Europe and America...
July 2014: Chest
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EDITORIAL
James A Russell
No abstract text is available yet for this article.
December 15, 2012: American Journal of Respiratory and Critical Care Medicine
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