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Theophylline use in chronic stable COPD.

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3 papers 0 to 25 followers
By Jason Mann No BS pulmonary critical care fellow
Yu-min Zhou, Xiao-ping Wang, Xiang-yi Zeng, Rong Qiu, Jun-fen Xie, Sheng-ming Liu, Jin-ping Zheng, Nan-shan Zhong, Pi-xin Ran
OBJECTIVE: To observe the benefits and safety of low-dose, slow-release oral theophylline for long-term treatment of stable chronic obstructive pulmonary disease (COPD). METHODS: This was a randomized, parallel-group, double-blind, placebo-controlled trial. Slow-release theophylline (200 mg/d) twice daily or placebo (matching theophylline) was randomly given to 110 patients with stable COPD in the rural area of Shaoguan, Guangdong Province, for one year. Efficacy measures were spirometry and exacerbations, quality of life, dyspnea scores, satisfaction with treatments and adverse effects...
September 2006: Chinese Journal of Tuberculosis and Respiratory Diseases
Peter J Barnes
Theophylline (dimethylxanthine) has been used to treat airway diseases for more than 80 years. It was originally used as a bronchodilator, but the relatively high doses required are associated with frequent side effects, so its use declined as inhaled β2-agonists became more widely used. More recently it has been shown to have antiinflammatory effects in asthma and chronic obstructive pulmonary disease (COPD) at lower concentrations. The molecular mechanism of bronchodilatation is inhibition of phosphodiesterase (PDE)3, but the antiinflammatory effect may be due to inhibition of PDE4 and histone deacetylase-2 activation, resulting in switching off of activated inflammatory genes...
October 15, 2013: American Journal of Respiratory and Critical Care Medicine
Felix S F Ram
PURPOSE OF REVIEW: The role of theophylline in the management of chronic obstructive pulmonary disease remains controversial. This review was undertaken to determine the efficacy of theophylline in patients with stable disease. RECENT FINDINGS: Twenty-two good quality randomized controlled trials were included in this systematic review. The review showed that theophylline significantly improved forced expiratory volume in 1 s and forced vital capacity (weighted mean difference 0...
March 2006: Current Opinion in Pulmonary Medicine
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