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Asma

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132 papers 100 to 500 followers
By Roberto Garay-Cabada Pediatrics , Fellow in pediatric Pulmonology
https://read.qxmd.com/read/30480592/asthma-obesity-and-targeted-interventions-an-update
#1
Helen Clare Ricketts, Douglas C Cowan
PURPOSE OF REVIEW: Obese asthma is now widely recognized as a phenotype of difficult asthma that is common and less responsive to traditional asthma treatments, so identifying specific treatments is increasingly important. RECENT FINDINGS: Obesity can lead to asthma through a complex relationship of causes including mechanical, inflammatory, metabolic and genetic factors. Exercise programmes including pulmonary rehabilitation, weight loss via dietary restriction, exercise and bariatric surgery, or combinations of all of these can improve quality of life, symptoms, and exercise capacity, with reductions in medication use and exacerbations, and represent tailored treatment for this phenotype of severe difficult to treat asthmatic patients...
February 2019: Current Opinion in Allergy and Clinical Immunology
https://read.qxmd.com/read/30507714/obesity-and-adiposity-indicators-in-asthma-and-allergic-rhinitis-in-children
#2
Hanako Tajima, Ruby Pawankar
PURPOSE OF REVIEW: The prevalence of obesity and allergic diseases, such as asthma and allergic rhinitis, is increasing worldwide not only in adults, but also in children. Experimental and clinical studies have demonstrated the effect of obesity not only on asthma, but also on other allergic diseases. RECENT FINDINGS: Allergic diseases, such as asthma and allergic rhinitis, are common chronic inflammatory diseases of the airways. Obesity is an increasingly common pediatric disease and is a risk factor for the development of asthma in that obese patients with asthma tend to have more severe asthma that does not respond well to standard asthma therapy...
February 2019: Current Opinion in Allergy and Clinical Immunology
https://read.qxmd.com/read/30514789/maternal-history-of-miscarriages-and-measures-of-fertility-in-relation-to-childhood-asthma
#3
Maria Christine Magnus, Øystein Karlstad, Christine Louise Parr, Christian M Page, Per Nafstad, Per Magnus, Stephanie J London, Allen J Wilcox, Wenche Nystad, Siri Eldevik Håberg
BACKGROUND: It remains unclear what underlies the greater risk of asthma reported among children conceived by assisted reproductive technologies (ART). OBJECTIVE: Our aim was to clarify the role of parental subfertility and unmeasured confounding on the association between ART and childhood asthma, and to examine the possibility for common mechanisms underlying parental subfertility and miscarriages influencing asthma pathogenesis. METHODS: We used data from national Norwegian health registries (n=474 402) and the Norwegian Mother and Child Cohort Study (MoBa) (n=75 797)...
December 4, 2018: Thorax
https://read.qxmd.com/read/30144926/quintupling-inhaled-fluticasone-at-first-sign-of-exacerbation
#4
COMMENT
Tim W Harrison
No abstract text is available yet for this article.
September 2018: Journal of Pediatrics
https://read.qxmd.com/read/30029599/early-life-vitamin-d-status-and-asthma-and-wheeze-a-systematic-review-and-meta-analysis
#5
Song-Ying Shen, Wan-Qing Xiao, Jin-Hua Lu, Ming-Yang Yuan, Jian-Rong He, Hui-Min Xia, Xiu Qiu, Kar Keung Cheng, Kin Bong Hubert Lam
BACKGROUND: Vitamin D deficiency has been linked to an increased risk of asthma. This study aimed to quantify the effect of early life vitamin D status on asthma and wheeze later in life. METHODS: PubMed, Embase, CINAHL, and CNKI databases, the Cochrane Central Register of Controlled Trials, and Google Scholar were searched up to July 2017. We included randomized controlled trials (RCTs) and cohort studies with vitamin D level in blood (maternal or cord or infant) or intake (maternal intake during pregnancy or infant intake) and asthma and/or wheeze...
July 20, 2018: BMC Pulmonary Medicine
https://read.qxmd.com/read/28697969/childhood-severe-asthma-new-insights-on-remodelling-and-biomarkers
#6
REVIEW
Sejal Saglani
Severe asthma in children is characterised by severe and multiple aeroallergen sensitisation, food allergy, eosinophilic airway inflammation and airway remodelling. However, it is a heterogeneous disease with considerable variability in the manifestation of each of these characteristics between patients. Recent data from mechanistic studies that have used translational approaches including neonatal mouse models and airway bronchoscopic samples, have shown specific molecular mediators that drive remodelling and steroid resistance in paediatric severe asthma will be discussed...
September 2017: Paediatric Respiratory Reviews
https://read.qxmd.com/read/29954359/evaluation-of-inhaler-technique-and-achievement-and-maintenance-of-mastery-of-budesonide-formoterol-spiromax%C3%A2-compared-with-budesonide-formoterol-turbuhaler%C3%A2-in-adult-patients-with-asthma-the-easy-low-instruction-over-time-eliot-study
#7
David B Price, Vicky Thomas, P N Richard Dekhuijzen, Sinthia Bosnic-Anticevich, Nicolas Roche, Federico Lavorini, Priyanka Raju, Daryl Freeman, Carole Nicholls, Iain R Small, Erika Sims, Guilherme Safioti, Janice Canvin, Henry Chrystyn
BACKGROUND: Incorrect inhaler technique is a common cause of poor asthma control. This two-phase pragmatic study evaluated inhaler technique mastery and maintenance of mastery with DuoResp® (budesonide-formoterol [BF]) Spiromax® compared with Symbicort® (BF) Turbuhaler® in patients with asthma who were receiving inhaled corticosteroids/long-acting β2-agonists. METHODS: In the initial cross-sectional phase, patients were randomized to a 6-step training protocol with empty Spiromax and Turbuhaler devices...
June 28, 2018: BMC Pulmonary Medicine
https://read.qxmd.com/read/29866794/respiratory-viruses-and-treatment-failure-in-children-with-asthma-exacerbation
#8
Joanna Merckx, Francine M Ducharme, Christine Martineau, Roger Zemek, Jocelyn Gravel, Dominic Chalut, Naveen Poonai, Caroline Quach
: media-1vid110.1542/5771275574001PEDS-VA_2017-4105 Video Abstract OBJECTIVES: Respiratory pathogens commonly trigger pediatric asthma exacerbations, but their impact on severity and treatment response remains unclear. METHODS: We performed a secondary analysis of the Determinants of Oral Corticosteroid Responsiveness in Wheezing Asthmatic Youth (DOORWAY) study, a prospective cohort study of children (aged 1-17 years) presenting to the emergency department with moderate or severe exacerbations...
July 2018: Pediatrics
https://read.qxmd.com/read/29790678/pediatric-pulmonology-year-in-review-2017-part-1
#9
REVIEW
William A Gower, David J Birnkrant, Jane B Black, Thomas Nicolai, Terry L Noah
Pediatric Pulmonology publishes original research, case reports and review articles on topics related to a wide range of children's respiratory disorders. In this article (Part 1 of a series), we summarize the past year's publications in our major topic areas, as well as selected literature in these areas from other journals. In Part 1, we review selected articles on diagnostic testing/endoscopy, respiratory complications of neuromuscular disorders, and rare lung diseases.
November 2018: Pediatric Pulmonology
https://read.qxmd.com/read/29785255/feasibility-of-high-intensity-training-in-asthma
#10
L L Toennesen, E D Soerensen, M Hostrup, C Porsbjerg, J Bangsbo, V Backer
Background: High-intensity interval training is an effective and popular training regime but its feasibility in untrained adults with asthma is insufficiently described. Objective: The randomized controlled trial 'EFFORT Asthma' explored the effects of behavioural interventions including high-intensity interval training on clinical outcomes in nonobese sedentary adults with asthma. In this article we present a sub analysis of data aiming to evaluate if patients' pre-intervention levels of asthma control, FEV1, airway inflammation and airway hyperresponsiveness (AHR) predicted their training response to the high-intensity interval training program, measured as increase in maximal oxygen consumption (VO2 max)...
2018: European Clinical Respiratory Journal
https://read.qxmd.com/read/29670674/tiotropium-for-the-treatment-of-asthma-patient-selection-and-perspectives
#11
REVIEW
V Madhu Chari, Robert Andrew McIvor
Asthma is a chronic disease of airway inflammation with a large global burden. Despite established, guideline-based stepwise therapy, a significant proportion of patients remain symptomatic and poorly controlled. As such, there is a need for additional safe, effective, convenient, and cost-effective therapies that can be broadly applied across a range of asthma phenotypes. Tiotropium is a long-acting muscarinic antagonist (LAMA) that leads to bronchodilation by blocking endogenous acetylcholine receptors in the airways...
2018: Canadian Respiratory Journal: Journal of the Canadian Thoracic Society
https://read.qxmd.com/read/29605203/in-vitro-and-clinical-characterization-of-the-valved-holding-chamber-aerochamber-plus-%C3%A2-flow-vu-%C3%A2-for-administrating-tiotropium-respimat-%C3%A2-in-1-5-year-old-children-with-persistent-asthmatic-symptoms
#12
Herbert Wachtel, Mark Nagel, Michael Engel, Georges El Azzi, Ashish Sharma, Jason Suggett
BACKGROUND: When characterizing inhalation products, a comprehensive assessment including in vitro, pharmacokinetic (PK), and clinical data is required. We conducted a characterization of tiotropium Respimat® when administered with AeroChamber Plus® Flow-Vu® anti-static valved holding chamber (test VHC) with face mask in 1-5-year-olds with persistent asthmatic symptoms. METHODS: In vitro tiotropium dose and particle size distribution delivered into a cascade impactor were evaluated under fixed paediatric and adult flow rates between actuation and samplings...
April 2018: Respiratory Medicine
https://read.qxmd.com/read/29693459/evaluating-the-effectiveness-of-systemic-corticosteroids-to-mitigate-relapse-in-children-assessed-and-treated-for-acute-asthma-a-network-meta-analysis
#13
Scott W Kirkland, Ben Vandermeer, Sandy Campbell, Cristina Villa-Roel, Amanda Newton, Francine M Ducharme, Brian H Rowe
OBJECTIVE: The objective of this systematic review was to explore the effectiveness of various systemic corticosteroid (SCS) regimens to mitigate relapse in children with asthma discharged from an acute care setting. DATA SOURCES: Medline, EMBASE, Global Health, International Pharmaceutical Abstracts, EMB ALL, CINAHL, SCOPUS, Proquest Dissertations and Theses Global, and LILACS were searched using controlled vocabulary and key words. Additional citations were searched via clinical trial registries, Google Scholar, bibliographies, a SCOPUS forward search of a sentinel paper, and hand searching conference abstracts...
May 2019: Journal of Asthma: Official Journal of the Association for the Care of Asthma
https://read.qxmd.com/read/29650006/beclomethasone-dipropionate-and-formoterol-fumarate-synergistically-interact-in-hyperresponsive-medium-bronchi-and-small-airways
#14
Luigino Calzetta, Maria Gabriella Matera, Francesco Facciolo, Mario Cazzola, Paola Rogliani
BACKGROUND: Corticosteroids increase the expression of β2 -adrenoceptors (β2 -ARs) and protect them against down-regulation. Conversely, β2 -AR agonists improve the anti-inflammatory action of corticosteroids. Nevertheless, it is still uncertain whether adding a long-acting β2 -AR agonist (LABA) to an inhaled corticosteroid (ICS) results in an additive effect, or there is true synergy. Therefore, the aim of this study was to pharmacologically characterize the interaction between the ICS beclomethasone diproprionate (BDP) and the LABA formoterol fumarate (FF) in a validated human ex vivo model of bronchial asthma...
April 12, 2018: Respiratory Research
https://read.qxmd.com/read/29625664/challenges-in-the-treatment-of-asthma-in-children-and-adolescents
#15
REVIEW
Stanley J Szefler, Bradley Chipps
OBJECTIVE: Despite the availability of effective treatments, asthma control in children and adolescents remains inadequate and rates of health care use are high. This follow-up to a recent review (O'Byrne et al, Eur Respir J. 2017;50[3]) examines a number of challenges in current pediatric asthma management compared with that of an adult perspective and discusses possible alternative strategies that might improve pediatric asthma management and control. DATA SOURCES: The evidence base for this review is limited because, historically, much of the research has been performed in adults...
April 2018: Annals of Allergy, Asthma & Immunology
https://read.qxmd.com/read/29302790/optimizing-the-dosing-of-intravenous-theophylline-in-acute-severe-asthma-in-children
#16
Gemma L Saint, Malcolm G Semple, Ian Sinha, Daniel B Hawcutt
Optimizing the management of children presenting with acute severe asthma is of utmost importance to minimize hospital stays, morbidity, and mortality. Intravenous medications, including theophyllines, are used as second-line treatments for children experiencing a life-threatening exacerbation. For intravenous theophylline (aminophylline), guidelines and formularies recommend a target therapeutic range between 10 and 20 mg/l, with the commonest regimen being a loading dose of 5 mg/kg followed by an infusion calculated by age and weight...
June 2018: Paediatric Drugs
https://read.qxmd.com/read/29301922/budesonide-formoterol-maintenance-and-reliever-therapy-in-adolescent-patients-with-asthma
#17
Carin Jorup, Dan Lythgoe, Hans Bisgaard
Asthma control is often suboptimal in adolescents, but few studies have evaluated asthma treatments in this population.This post hoc analysis assessed the efficacy and safety of budesonide/formoterol (BUD/FORM) maintenance and reliever therapy (MART) for treatment of persistent asthma in adolescent (age 12-17 years) subgroups within six randomised, double-blind trials. The primary end-point was time to first severe exacerbation. Secondary end-points included number of severe exacerbations, asthma-related symptoms, night-time awakenings, morning peak expiratory flow, forced expiratory volume in 1 s, as-needed medication use and five-item asthma control questionnaire scores...
January 2018: European Respiratory Journal: Official Journal of the European Society for Clinical Respiratory Physiology
https://read.qxmd.com/read/29197105/upper-and-lower-airway-remodelling-mechanisms-in-asthma-allergic-rhinitis-and-chronic-rhinosinusitis-the-one-airway-concept-revisited
#18
REVIEW
K Samitas, A Carter, H H Kariyawasam, G Xanthou
Allergic rhinitis (AR), chronic rhinosinusitis (CRS) and asthma often co-exist. The one airway model proposes that disease mechanisms occurring in the upper airway may mirror lower airway events. Airway remodelling is the term used to describe tissue structural changes that occur in a disease setting and reflect the dynamic process of tissue restructuring during wound repair. Remodelling has been long identified in the lower airways in asthma and is characterized by epithelial shedding, goblet cell hyperplasia, basement membrane thickening, subepithelial fibrosis, airway smooth muscle hyperplasia and increased angiogenesis...
May 2018: Allergy
https://read.qxmd.com/read/29105786/influenza-burden-prevention-and-treatment-in-asthma-a-scoping-review-by-the-eaaci-influenza-in-asthma-task-force
#19
REVIEW
J Schwarze, P Openshaw, A Jha, S R Del Giacco, D Firinu, O Tsilochristou, G Roberts, A Selby, C Akdis, I Agache, A Custovic, E Heffler, G Pinna, M Khaitov, A Nikonova, N Papadopoulos, A Akhlaq, U Nurmatov, H Renz, A Sheikh, C Skevaki
To address uncertainties in the prevention and management of influenza in people with asthma, we performed a scoping review of the published literature on influenza burden; current vaccine recommendations; vaccination coverage; immunogenicity, efficacy, effectiveness, and safety of influenza vaccines; and the benefits of antiviral drugs in people with asthma. We found significant variation in the reported rates of influenza detection in individuals with acute asthma exacerbations making it unclear to what degree influenza causes exacerbations of underlying asthma...
June 2018: Allergy
https://read.qxmd.com/read/29079610/duration-of-the-efficacy-of-omalizumab-after-treatment-discontinuation-in-real-life-severe-asthma
#20
LETTER
Maria Del Carmen Vennera, Carlos Sabadell, Cesar Picado
Efficacy of omalizumab in severe asthma is well documented; however, the optimal duration of the treatment remains unclear. In an open prospective study, we sought to assess the persistence of response in subjects withdrawing from omalizumab treatment. We evaluated 49 patients who voluntarily accepted to discontinue omalizumab treatment after 6 years of therapy. Asthma relapse was defined as any severe asthma exacerbation associated with loss of asthma control. Twelve patients relapsed in the first year of follow-up, and 7 within 13 and 48 months...
August 2018: Thorax
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