Naoki Kohei, Tatsu Tanabe, Shigeru Horita, Kazuya Omoto, Hideki Ishida, Yutaka Yamaguchi, Kazunari Tanabe
Alloantibodies contribute significantly to renal transplant rejection by activation of complement and various cytokines with a variety of effector cells, and are a major cause of allograft loss. Although there is clinical evidence of antibody- and complement-mediated injury in renal transplantation, the mechanism of antibody-mediated rejection remains largely unknown. In order to understand the sequential production of antibodies and complement components, we presensitized recipient rats by skin transplantation...
October 2013: Kidney International