Zobair M Younossi, David Bernstein, Mitchell L Shiffman, Paul Kwo, W Ray Kim, Kris V Kowdley, Ira M Jacobson
Primary biliary cholangitis (PBC) is a chronic, cholestatic, autoimmune disease with a variable progressive course. PBC can cause debilitating symptoms including fatigue and pruritus and, if left untreated, is associated with a high risk of cirrhosis and related complications, liver failure, and death. Recent changes to the PBC landscape include a name change, updated guidelines for diagnosis and treatment as well as new treatment options that have recently become available. Practicing clinicians face many unanswered questions when managing PBC...
January 2019: American Journal of Gastroenterology