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DRG

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202 papers 25 to 100 followers
By Xander Zuidema MD, pharmD, Anesthesiologist, intensivist, pain specialist
https://read.qxmd.com/read/30844113/lumbar-5-nerve-root-injury-following-dorsal-root-ganglion-stimulator-lead-placement
#1
LETTER
Zan Khan, Hariharan Shankar
No abstract text is available yet for this article.
March 7, 2019: Neuromodulation: Journal of the International Neuromodulation Society
https://read.qxmd.com/read/30861286/paresthesia-free-dorsal-root-ganglion-stimulation-an-accurate-study-sub-analysis
#2
Nagy Mekhail, Timothy R Deer, Jeffery Kramer, Lawrence Poree, Kasra Amirdelfan, Eric Grigsby, Peter Staats, Allen W Burton, Abram H Burgher, James Scowcroft, Stanley Golovac, Leonardo Kapural, Richard Paicius, Jason Pope, Samuel Samuel, William Porter McRoberts, Michael Schaufele, Alexander R Kent, Adil Raza, Robert M Levy
INTRODUCTION: ACCURATE, a randomized controlled trial comparing dorsal root ganglion (DRG) stimulation to spinal cord stimulation, showed that DRG stimulation is a safe and effective therapy in individuals with lower extremity chronic pain due to complex regional pain syndrome (CRPS) type I or II. Investigators noted that DRG stimulation programming could be adjusted to minimize, or eliminate, the feeling of paresthesia while maintaining adequate pain relief. The present study explores treatment outcomes for DRG subjects who were paresthesia-free vs...
March 12, 2019: Neuromodulation: Journal of the International Neuromodulation Society
https://read.qxmd.com/read/30861617/safety-analysis-of-dorsal-root-ganglion-stimulation-in-the-treatment-of-chronic-pain
#3
Timothy Deer, Jason Pope, Corey Hunter, Steven Falowski, Leonardo Kapural, Jeffery Kramer, Robert Levy
BACKGROUND: Stimulation of the dorsal root ganglion (DRG) in the treatment of chronic, intractable pain has shown excellent clinical results in multiple published studies, including a large prospective, randomized, controlled trial. Both safety and efficacy have been demonstrated utilizing this therapeutic approach for many chronic complaints. Continued assessment of neuromodulation therapies, such as DRG stimulation, are not only an important aspect of vigilant care, but are also necessary for the evaluation for safety...
March 12, 2019: Neuromodulation: Journal of the International Neuromodulation Society
https://read.qxmd.com/read/30821901/a-prospective-study-of-dorsal-root-ganglion-stimulation-for-non-operated-discogenic-low-back-pain
#4
Jan Willem Kallewaard, Caro Edelbroek, Michel Terheggen, Adil Raza, Jose W Geurts
INTRODUCTION: Disruptions of lumbar intervertebral discs may lead to severe discogenic low back pain (LBP). Severe pain has a deleterious effect on physical function and quality of life. Spinal cord stimulation (SCS) is a robust treatment for many neuropathic pain conditions. New innovations may be well-suited to treat neuropathic chronic LBP, including discogenic pain. The aim of this prospective study was to determine the effect of dorsal root ganglion (DRG) stimulation for a well-selected group of patients with discogenic LBP with no history of previous back surgeries...
March 1, 2019: Neuromodulation: Journal of the International Neuromodulation Society
https://read.qxmd.com/read/30762923/dorsal-root-ganglion-stimulation-as-a-potentially-effective-treatment-for-painful-hereditary-and-idiopathic-axonal-polyneuropathy-a-retrospective-case-series
#5
Kwo Wei David Ho, Torge Rempe, Nivedita Jerath, Ajay Antony
OBJECTIVES: Dorsal root ganglion (DRG) stimulation has been demonstrated to be effective in treating painful diabetic polyneuropathy in a small case series. However, diabetic polyneuropathy only accounts for 41% of all polyneuropathies and the efficacy of DRG on other types of polyneuropathy is unclear. The objective of this study is to evaluate the efficacy of DRG stimulation in treating painful hereditary and idiopathic axonal polyneuropathy. MATERIALS AND METHODS: This is a monocentric retrospective case series...
February 14, 2019: Neuromodulation: Journal of the International Neuromodulation Society
https://read.qxmd.com/read/30640660/retrospective-analysis-of-complications-associated-with-dorsal-root-ganglion-stimulation-for-pain-relief-in-the-fda-maude-database
#6
Eellan Sivanesan, Mark C Bicket, Steven P Cohen
BACKGROUND AND OBJECTIVES: Dorsal root ganglion stimulation is an emerging therapy in the treatment of chronic pain. Compared with traditional spinal cord stimulation, it allows a discretely targeted stimulation profile and may act via differing mechanisms of action. Despite these advantages, little is known about the complications associated with this new modality. METHODS: We queried the MAUDE (Manufacturer and User Facility Device Experience) database for all entries named 'Dorsal root ganglion stimulator for pain relief' reported between May 1, 2016 and December 31, 2017...
January 2019: Regional Anesthesia and Pain Medicine
https://read.qxmd.com/read/30671236/retained-catheter-during-placement-of-dorsal-root-ganglion-stimulator-a-case-report
#7
Gurkirat Kohli, Shawn Amin, Yehuda Herschman, Antonios Mammis
Dorsal root ganglion (DRG) stimulation is a novel therapeutic option that is being increasingly utilized for patients with neuropathic pain. The potential complications during the placement of this device remain unknown. We describe a potential complication during DRG stimulator placement not previously reported in the literature. A 50-year-old male presented to the ED with lower back pain and right lower extremity radicular pain following placement of DRG stimulator at outside facility. A fragment of an introducer catheter was retained in the spinal canal and L2-L3 neural foramen...
February 2019: British Journal of Pain
https://read.qxmd.com/read/30701632/dorsal-root-ganglion-stimulation-is-paresthesia-independent-a-retrospective-study
#8
Paul Verrills, Bruce Mitchell, David Vivian, William Cusack, Jeffery Kramer
INTRODUCTION: Neuromodulation is an important tool for achieving pain relief in otherwise-intractable neuropathic pain conditions. Dorsal root ganglion (DRG) stimulation, in which primary sensory neurons are stimulated prior to their entry into the spinal canal, provides treatment with high levels of dermatomal specificity and can provide advantages compared to conventional spinal cord stimulation. Although DRG stimulation can produce perceptible paresthesias, many patients operate their systems at subthreshold amplitudes that do not elicit this sensation...
January 30, 2019: Neuromodulation: Journal of the International Neuromodulation Society
https://read.qxmd.com/read/30657984/classical-predictors-do-not-predict-success-with-sacral-nerve-stimulation-for-chronic-pelvic-pain-a-retrospective-review-in-a-single-center
#9
Muhammad Kashif, Andreas Goebel, Vanja Srbljak, Rajiv Chawla, Mark Draper, Alison Cox, Manohar Sharma
No abstract text is available yet for this article.
January 17, 2019: Pain Medicine: the Official Journal of the American Academy of Pain Medicine
https://read.qxmd.com/read/30620789/cervical-and-high-thoracic-dorsal-root-ganglion-stimulation-in-chronic-neuropathic-pain
#10
Guilherme Santos Piedade, Jan Vesper, Apostolos Chatzikalfas, Philipp J Slotty
INTRODUCTION: Dorsal root ganglion stimulation is a meanwhile established but rather new technique of neuromodulation to treat chronic pain states of different origin. While being primarily used in the lumbar region, dorsal root ganglion (DRG) stimulation also can be used in the upper thoracic and cervical region with slight alterations of the surgical approach. This offers new therapeutic options especially in the treatment of neuropathic pain states of the upper extremities. Data on surgical technique, outcome and complications rates of DRG in this region are limited...
January 8, 2019: Neuromodulation: Journal of the International Neuromodulation Society
https://read.qxmd.com/read/30624003/comparison-of-paresthesia-coverage-of-patient-s-pain-dorsal-root-ganglion-vs-spinal-cord-stimulation-an-accurate-study-sub-analysis
#11
Timothy R Deer, Robert M Levy, Jeffery Kramer, Lawrence Poree, Kasra Amirdelfan, Eric Grigsby, Peter Staats, Abram H Burgher, James Scowcroft, Stan Golovac, Leonardo Kapural, Richard Paicius, Jason E Pope, Sam Samuel, William Porter McRoberts, Michael Schaufele, Allen W Burton, Adil Raza, Filippo Agnesi, Nagy Mekhail
OBJECTIVES: This was a sub-analysis of the ACCURATE clinical trial that evaluated the accuracy and necessity of targeting paresthesia coverage of painful areas with dorsal root ganglion (DRG) stimulation vs. tonic spinal cord stimulation (SCS). MATERIALS AND METHODS: On diagrams of the torso and lower limbs, subjects marked where they felt pain at baseline and paresthesias at three months postimplant. Seventy-five subjects (41 DRG and 34 SCS) with diagrams of sufficient quality were scanned, digitized, and included in this analysis...
January 9, 2019: Neuromodulation: Journal of the International Neuromodulation Society
https://read.qxmd.com/read/30570187/dorsal-root-ganglion-stimulation-in-experimental-painful-diabetic-peripheral-neuropathy-burst-vs-conventional-stimulation-paradigm
#12
Glenn Franken, Jacques Debets, Elbert A J Joosten
OBJECTIVES: Painful diabetic peripheral neuropathy (PDPN) is a long-term complication of diabetes mellitus (DM). Dorsal Root Ganglion Stimulation (DRGS) has recently emerged as a neuromodulation modality in the treatment of chronic neuropathic pain. The objective of this study was to compare the effect of burst DRGS (Burst-DRGS) and conventional DRGS (Con-DRGS) in an experimental model of PDPN. MATERIALS AND METHODS: DM was induced in female Sprague-Dawley rats by intraperitoneal injection of streptozotocin (STZ, n = 48)...
December 20, 2018: Neuromodulation: Journal of the International Neuromodulation Society
https://read.qxmd.com/read/30561852/neurophysiological-effects-of-dorsal-root-ganglion-stimulation-drgs-in-pain-processing-at-the-cortical-level
#13
Matthias Hubert Morgalla, Marcos Fortunato de Barros Filho, Bankim Subhash Chander, Surjo Raphael Soekadar, Marcos Tatagiba, Guilherme Lepski
OBJECTIVES: Dorsal root ganglion stimulation (DRGS) has been used successfully against localized neuropathic pain. Nevertheless, the effects of DRGS on pain processing, particularly at the cortical level, remain largely unknown. In this study, we investigated whether positive responses to DRGS treatment would alter patients' laser-evoked potentials (LEP). METHODS: We prospectively enrolled 12 adult patients with unilateral localized neuropathic pain in the lower limbs or inguinal region and followed them up for six months...
January 2019: Neuromodulation: Journal of the International Neuromodulation Society
https://read.qxmd.com/read/30503336/electrical-stimulation-accelerates-neurite-regeneration-in-axotomized-dorsal-root-ganglion-neurons-by-increasing-mmp-2-expression
#14
Sungmin Han, Dong Hwee Kim, Joohwan Sung, Hwasun Yang, Jong Woong Park, Inchan Youn
Electrical stimulation (ES) can be useful for promoting the regeneration of injured axons, but the mechanism underlying its positive effects is largely unknown. The current study aimed to investigate whether ES could enhance the regeneration of injured neurites in dorsal root ganglion explants and regulate the MMP-2 expression level, which is correlated with regeneration. Significantly increased neurite regeneration and MMP-2 expression was observed in the ES group compared with the sham group. However, an MMP inhibitor significantly decreased this ES-induced neurite regeneration...
November 28, 2018: Biochemical and Biophysical Research Communications
https://read.qxmd.com/read/30506911/dorsal-root-ganglion-stimulation-for-the-treatment-of-persistent-post-mastectomy-pain-case-report
#15
LETTER
Matthias Hubert Morgalla
No abstract text is available yet for this article.
December 2, 2018: Neuromodulation: Journal of the International Neuromodulation Society
https://read.qxmd.com/read/30467478/selective-blockade-of-hcn1-hcn2-channels-as-a-potential-pharmacological-strategy-against-pain
#16
Leonardo Dini, Martina Del Lungo, Francesco Resta, Michele Melchiorre, Valentina Spinelli, Lorenzo Di Cesare Mannelli, Carla Ghelardini, Annunziatina Laurino, Laura Sartiani, Raffaele Coppini, Guido Mannaioni, Elisabetta Cerbai, Maria Novella Romanelli
A prominent role of hyperpolarization-activated, cyclic nucleotide-gated (HCN) channels has been suggested based on their expression and (dys)function in dorsal root ganglion (DRG) neurons, being likely involved in peripheral nociception. Using HCN blockers as antinociceptive drugs is prevented by the widespread distribution of these channels. However, tissue-specific expression of HCN isoforms varies significantly, HCN1 and HCN2 being considered as major players in DRG excitability. We characterized the pharmacological effect of a novel compound, MEL55A, able to block selectively HCN1/HCN2 isoforms, on DRG neuron excitability in-vitro and for its antiallodynic properties in-vivo ...
2018: Frontiers in Pharmacology
https://read.qxmd.com/read/30412243/chemotherapy-induced-peripheral-neuropathy-treated-with-dorsal-root-ganglion-stimulation
#17
Pauline S Groenen, Noud van Helmond, Kenneth B Chapman
No abstract text is available yet for this article.
November 8, 2018: Pain Medicine: the Official Journal of the American Academy of Pain Medicine
https://read.qxmd.com/read/30358008/selective-l4-dorsal-root-ganglion-stimulation-evokes-pain-relief-and-changes-of-inflammatory-markers-part-i-profiling-of-saliva-and-serum-molecular-patterns
#18
Nadine Gravius, Shafqat R Chaudhry, Sajjad Muhammad, Azize Boström, Sascha Gravius, Thomas Randau, Dirk Scheele, Philipp Westhofen, Johannes Kruppenbacher, Birgit Stoffel-Wagner, Christian Maier, Anna Weidlich, Thomas L Yearwood, Krishnan V Chakravarthy, Jeffery M Kramer, Rene Hurlemann, Thomas M Kinfe
OBJECTIVES: Complex regional pain syndrome (CRPS) and associated comorbidities have been linked to a pro-inflammatory state driven by different mediators. Targeted dorsal root ganglion stimulation (DRGSTIM ) suppressed pain levels and improved functional capacity in intractable CRPS. However, clinical trials assessing the impact of DRG stimulation on the neuroimmune axis are lacking. METHODS: This study enrolled 24 subjects (12 refractory CRPS patients plus suitably matched healthy controls) and performed immunoassays of inflammatory mediators in saliva and serum along with score-based assessments of pain, mood, and sleep quality at baseline and after three months of selective L4-DRGSTIM ...
October 25, 2018: Neuromodulation: Journal of the International Neuromodulation Society
https://read.qxmd.com/read/30269439/prospective-cohort-analysis-of-drg-stimulation-for-failed-back-surgery-syndrome-pain-following-lumbar-discectomy
#19
Jan Willem Kallewaard, Harold Nijhuis, Frank Huygen, Frank Wille, Xander Zuidema, Johan van de Minkelis, Adil Raza
INTRODUCTION: Surgical lumbar discectomy is a commonly performed routine spinal procedure that is usually undertaken to alleviate lumbar radicular symptoms caused by a herniated intervertebral disc. Surgical lumbar discectomy can also lead to chronic postsurgical leg and/or back pain (failed back surgery syndrome [FBSS]), a condition that can be refractory to conventional medical management. Early clinical results on the use of dorsal root ganglion (DRG) stimulation for FBSS have supported the use of this treatment alternative...
September 30, 2018: Pain Practice: the Official Journal of World Institute of Pain
https://read.qxmd.com/read/30236868/expression-of-acetyl-histone-h3-and-acetyl-histone-h4-in-dorsal-root-ganglion-and-spinal-dorsal-horn-in-rat-chronic-pain-models
#20
Lingli Liang, Yuan-Xiang Tao
AIMS: Histone acetylation and deacetylation are two histone posttranslational modifications that are usually controlled by histone acetyltransferases (HATs) and histone deacetylases (HDACs). Although HATs or HDACs Inhibitors could relieve pain hypersensitivities in chronic pain animal models, it is not clear on the expression of global histone acetylation in the dorsal root ganglion (DRG) or spinal dorsal horn in chronic pain conditions. MAIN METHODS: A spinal nerve ligation (SNL)-induced neuropathic pain model and a complete Freund's adjuvant (CFA)-induced inflammatory pain model in rats were used to examine the expression of total acetyl-histone H3 (AcH3) and total acetyl-histone H4 (AcH4) by immunofluorescence or western blot...
October 15, 2018: Life Sciences
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