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Vascular Surgery Seminal Papers

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11 papers 100 to 500 followers
Deepak L Bhatt, David E Kandzari, William W O'Neill, Ralph D'Agostino, John M Flack, Barry T Katzen, Martin B Leon, Minglei Liu, Laura Mauri, Manuela Negoita, Sidney A Cohen, Suzanne Oparil, Krishna Rocha-Singh, Raymond R Townsend, George L Bakris
BACKGROUND: Prior unblinded studies have suggested that catheter-based renal-artery denervation reduces blood pressure in patients with resistant hypertension. METHODS: We designed a prospective, single-blind, randomized, sham-controlled trial. Patients with severe resistant hypertension were randomly assigned in a 2:1 ratio to undergo renal denervation or a sham procedure. Before randomization, patients were receiving a stable antihypertensive regimen involving maximally tolerated doses of at least three drugs, including a diuretic...
April 10, 2014: New England Journal of Medicine
Leo H Bonati, Joanna Dobson, Roland L Featherstone, Jörg Ederle, H Bart van der Worp, Gert J de Borst, Willem P Th M Mali, Jonathan D Beard, Trevor Cleveland, Stefan T Engelter, Philippe A Lyrer, Gary A Ford, Paul J Dorman, Martin M Brown
BACKGROUND: Stenting is an alternative to endarterectomy for treatment of carotid artery stenosis, but long-term efficacy is uncertain. We report long-term data from the randomised International Carotid Stenting Study comparison of these treatments. METHODS: Patients with symptomatic carotid stenosis were randomly assigned 1:1 to open treatment with stenting or endarterectomy at 50 centres worldwide. Randomisation was computer generated centrally and allocated by telephone call or fax...
February 7, 2015: Lancet
H J M Barnett, D W Taylor, R B Haynes, D L Sackett, S J Peerless, G G Ferguson, A J Fox, R N Rankin, V C Hachinski, D O Wiebers, M Eliasziw
BACKGROUND: Without strong evidence of benefit, the use of carotid endarterectomy for prophylaxis against stroke rose dramatically until the mid-1980s, then declined. Our investigation sought to determine whether carotid endarterectomy reduces the risk of stroke among patients with a recent adverse cerebrovascular event and ipsilateral carotid stenosis. METHODS: We conducted a randomized trial at 50 clinical centers throughout the United States and Canada, in patients in two predetermined strata based on the severity of carotid stenosis--30 to 69 percent and 70 to 99 percent...
August 15, 1991: New England Journal of Medicine
(no author information available yet)
BACKGROUND: Although endovascular aneurysm repair (EVAR) has a lower 30-day operative mortality than open repair, the long-term results of EVAR are uncertain. We instigated EVAR trial 1 to compare these two treatments in terms of mortality, durability, health-related quality of life (HRQL), and costs for patients with large abdominal aortic aneurysm (AAA). METHODS: We did a randomised controlled trial of 1082 patients aged 60 years or older who had aneurysms of at least 5...
June 25, 2005: Lancet
Jorg L De Bruin, Annette F Baas, Jaap Buth, Monique Prinssen, Eric L G Verhoeven, Philippe W M Cuypers, Marc R H M van Sambeek, Ron Balm, Diederick E Grobbee, Jan D Blankensteijn
BACKGROUND: For patients with large abdominal aortic aneurysms, randomized trials have shown an initial overall survival benefit for elective endovascular repair over conventional open repair. This survival difference, however, was no longer significant in the second year after the procedure. Information regarding the comparative outcome more than 2 years after surgery is important for clinical decision making. METHODS: We conducted a long-term, multicenter, randomized, controlled trial comparing open repair with endovascular repair in 351 patients with an abdominal aortic aneurysm of at least 5 cm in diameter who were considered suitable candidates for both techniques...
May 20, 2010: New England Journal of Medicine
J T Powell, L C Brown, J F Forbes, F G R Fowkes, R M Greenhalgh, C V Ruckley, S G Thompson
BACKGROUND: The aim was to determine whether early open surgical repair would benefit patients with small abdominal aortic aneurysm compared with surveillance on long-term follow-up. METHODS: The 1090 patients who were enrolled into the UK Small Aneurysm Trial between 1991 and 1995 were followed up for aneurysm repair and mortality until November 2005. RESULTS: By November 2005, 714 patients (65.5 per cent) had died, 929 (85.2 per cent) had undergone aneurysm repair, 150 (13...
June 2007: British Journal of Surgery
Monique Prinssen, Eric L G Verhoeven, Jaap Buth, Philippe W M Cuypers, Marc R H M van Sambeek, Ron Balm, Erik Buskens, Diederick E Grobbee, Jan D Blankensteijn
BACKGROUND: Although the initial results of endovascular repair of abdominal aortic aneurysms were promising, current evidence from controlled studies does not convincingly show a reduction in 30-day mortality relative to that achieved with open repair. METHODS: We conducted a multicenter, randomized trial comparing open repair with endovascular repair in 345 patients who had received a diagnosis of abdominal aortic aneurysm of at least 5 cm in diameter and who were considered suitable candidates for both techniques...
October 14, 2004: New England Journal of Medicine
Vito A Mantese, Carlos H Timaran, David Chiu, Richard J Begg, Thomas G Brott
BACKGROUND AND PURPOSE: Carotid artery stenosis causes up to 10% of all ischemic strokes. Carotid endarterectomy (CEA) was introduced as a treatment to prevent stroke in the early 1950s. Carotid stenting (CAS) was introduced as a treatment to prevent stroke in 1994. METHODS: The Carotid Revascularization Endarterectomy versus Stenting Trial (CREST) is a randomized trial with blinded end point adjudication. Symptomatic and asymptomatic patients were randomized to CAS or CEA...
October 2010: Stroke; a Journal of Cerebral Circulation
A Halliday, A Mansfield, J Marro, C Peto, R Peto, J Potter, D Thomas
BACKGROUND: Among patients with substantial carotid artery narrowing but no recent neurological symptom (stroke or transient ischaemia), the balance of surgical risks and long-term benefits from carotid endarterectomy (CEA) was unclear. METHODS: During 1993-2003, 3120 asymptomatic patients with substantial carotid narrowing were randomised equally between immediate CEA (half got CEA by 1 month, 88% by 1 year) and indefinite deferral of any CEA (only 4% per year got CEA) and were followed for up to 5 years (mean 3...
May 8, 2004: Lancet
G G Ferguson, M Eliasziw, H W Barr, G P Clagett, R W Barnes, M C Wallace, D W Taylor, R B Haynes, J W Finan, V C Hachinski, H J Barnett
BACKGROUND AND PURPOSE: This study reports the surgical results in those patients who underwent carotid endarterectomy in the North American Symptomatic Carotid Endarterectomy Trial (NASCET). METHODS: The rates of perioperative stroke and death at 30 days and the final assessment of stroke severity at 90 days were calculated. Regression modeling was used to identify variables that increased or decreased perioperative risk. Nonoutcome surgical complications were summarized...
September 1999: Stroke; a Journal of Cerebral Circulation
Andrew W Bradbury, Donald J Adam, Jocelyn Bell, John F Forbes, F Gerry R Fowkes, Ian Gillespie, Charles Vaughan Ruckley, Gillian M Raab
BACKGROUND: A 2005 interim analysis of the Bypass versus Angioplasty in Severe Ischaemia of the Leg (BASIL) trial showed that in patients with severe lower limb ischemia (SLI; rest pain, ulceration, gangrene) due to infrainguinal disease, bypass surgery (BSX)-first and balloon angioplasty (BAP)-first revascularization strategies led to similar short-term clinical outcomes, although BSX was about one-third more expensive and morbidity was higher. We have monitored patients for a further 2...
May 2010: Journal of Vascular Surgery
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